Interstitial Lung Disease

Respiratory
7
Pipeline Programs
6
Companies
7
Clinical Trials
3 recruiting
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
3
0
1
3
Early DiscoveryClinical DevelopmentMarket

On Market (3)

Approved therapies currently available

U
LAZANDAApproved
fentanyl citrate
Unknown Company
nasal2011
U
ONSOLISApproved
fentanyl citrate
Unknown Company
buccal2009
U
SUBLIMAZE PRESERVATIVE FREEApproved
fentanyl citrate
Unknown Company
injection1968

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
3 programs
1
1
Fentanyl CitratePhase 31 trial
[68Ga]CBP8Phase 21 trial
Interstitial Lung Diseases in the Veterans AdministrationN/A1 trial
Active Trials
NCT02479126Unknown3,000Est. Jun 2023
NCT05417776Recruiting30Est. Apr 2026
NCT03018756Completed21Est. Nov 2020
M&
Merck & Co.RAHWAY, NJ
1 program
1
INS316 solution for inhalationPhase 21 trial
Active Trials
NCT01381666Terminated22Est. Apr 2004
aTyr Pharma
aTyr PharmaSAN DIEGO, CA
1 program
1
efzofitimod 450 mgPhase 21 trial
Active Trials
NCT05892614Recruiting25Est. Apr 2026
Genentech
GenentechCA - Oceanside
1 program
Genentech Validation Tool for Pulmonary FibrosisN/A1 trial
Active Trials
NCT04676594Active Not Recruiting400Est. Aug 2026
United Therapeutics
United TherapeuticsMD - Silver Spring
1 program
Right heart catheterizationN/A1 trial
Active Trials
NCT05776225Recruiting300Est. Apr 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Boehringer IngelheimFentanyl Citrate
aTyr Pharmaefzofitimod 450 mg
Boehringer Ingelheim[68Ga]CBP8
Merck & Co.INS316 solution for inhalation
United TherapeuticsRight heart catheterization
GenentechGenentech Validation Tool for Pulmonary Fibrosis
Boehringer IngelheimInterstitial Lung Diseases in the Veterans Administration

Clinical Trials (7)

Total enrollment: 3,798 patients across 7 trials

NCT03018756Boehringer IngelheimFentanyl Citrate

Nebulized Fentanyl in Patients With Mild to Moderate Interstitial Lung Disease and Chronic Dyspnea

Start: Jan 2017Est. completion: Nov 202021 patients
Phase 3Completed
NCT05892614aTyr Pharmaefzofitimod 450 mg

Study to Evaluate the Efficacy, Safety, and Tolerability of Efzofitimod in Patients With Systemic Sclerosis (SSc)-Related Interstitial Lung Disease (ILD) (SSc-ILD)

Start: Oct 2023Est. completion: Apr 202625 patients
Phase 2Recruiting
NCT05417776Boehringer Ingelheim[68Ga]CBP8

Collagen-targeted PET Imaging for Early Interstitial Lung Disease

Start: Sep 2022Est. completion: Apr 202630 patients
Phase 2Recruiting
NCT01381666Merck & Co.INS316 solution for inhalation

Evaluation of the Diagnostic Utility of INS316 in Patients With Interstitial Lung Diseases (01-701)

Start: Jan 2003Est. completion: Apr 200422 patients
Phase 2Terminated
NCT05776225United TherapeuticsRight heart catheterization

Pulmonary Hypertension Screening in Patients With Interstitial Lung Disease for Earlier Detection

Start: Aug 2023Est. completion: Apr 2026300 patients
N/ARecruiting
NCT04676594GenentechGenentech Validation Tool for Pulmonary Fibrosis

Genentech Validation Tool for Pulmonary Fibrosis

Start: Oct 2020Est. completion: Aug 2026400 patients
N/AActive Not Recruiting
NCT02479126Boehringer IngelheimInterstitial Lung Diseases in the Veterans Administration

Interstitial Lung Diseases in the Veterans Administration

Start: Jul 2016Est. completion: Jun 20233,000 patients
N/AUnknown

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
3 actively recruiting trials targeting 3,798 patients
6 companies competing in this space

Related Indications

Asthma(378)Pulmonary Disease, Chronic Obstructive(263)Chronic Obstructive Pulmonary Disease(123)Idiopathic Pulmonary Fibrosis(90)COPD(74)Chronic Obstructive Pulmonary Disease (COPD)(38)Pulmonary Embolism(27)Respiratory Syncytial Virus Infections(26)Severe Asthma(21)Lung Diseases, Interstitial(19)