Hypertension, Pulmonary

Cardiovascular
22
Pipeline Programs
10
Companies
50
Clinical Trials
1 recruiting
8
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
0
2
0
5
11
Early DiscoveryClinical DevelopmentMarket

On Market (8)

Approved therapies currently available

Eli Lilly and Company
ADCIRCAApproved
tadalafil
Eli Lilly and Company
Phosphodiesterase 5 Inhibitor [EPC]oral2009
Bayer
ADEMPASApproved
riociguat
Bayer
Soluble Guanylate Cyclase Stimulator [EPC]oral2013
U
AURLUMYNApproved
iloprost
Unknown Company
Prostacycline [EPC]intravenous2024
U
CHEWTADZYApproved
tadalafil
Unknown Company
oral2024
Eli Lilly and Company
CIALISApproved
tadalafil
Eli Lilly and Company
Phosphodiesterase 5 Inhibitor [EPC]oral2003
GS
LETAIRISApproved
ambrisentan
Gilead Sciences
Endothelin Receptor Antagonist [EPC]oral2007
U
TADALAFILApproved
tadalafil
Unknown Company
oral2018
U
TADLIQApproved
tadalafil
Unknown Company
Phosphodiesterase 5 Inhibitor [EPC]oral2022

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
8 programs
2
2
1
ADEMPAS(Riociguat)Phase 45 trials
IloprostPhase 31 trial
VentavisPhase 31 trial
BAY1237592Phase 11 trial
RiociguatPhase 11 trial
+3 more programs
Active Trials
NCT02576002Completed2,691Est. Jan 2016
NCT02536534Completed35Est. Dec 2016
NCT03293407Completed31Est. Jan 2020
+13 more trials
United Therapeutics
United TherapeuticsMD - Silver Spring
4 programs
2
2
treprostinil sodiumPhase 41 trial
treprostinil sodiumPhase 41 trial
Treprostinil diethanolaminePhase 11 trial
Treprostinil diethanolaminePhase 11 trial
Active Trials
NCT00963027Completed30Est. Oct 2009
NCT00963001Completed32Est. Nov 2009
NCT00458042Terminated10Est. Nov 2007
+1 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
1
TadalafilPhase 31 trial
Active Trials
NCT01824290Completed35Est. Mar 2021
GS
Gilead SciencesFOSTER CITY, CA
1 program
1
1
ambrisentanPhase 31 trial
Active Trials
NCT01178073Completed610Est. Jul 2014
M&
Merck & Co.RAHWAY, NJ
1 program
1
RiociguatPhase 31 trial
Active Trials
NCT02562235Active Not Recruiting24Est. Aug 2027
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
2 programs
2
TerbogrelPhase 21 trial
Terbogrel low dosePhase 21 trial
Active Trials
NCT02223494Terminated33
NCT02223481Completed71
Eko Devices
Eko DevicesCA - Emeryville
1 program
Eko CORE 500 Digital StethoscopeN/A1 trial
Active Trials
NCT07087613Recruiting3,850Est. Aug 2026
Pfizer
PfizerNEW YORK, NY
1 program
EndoPAT measurementN/A1 trial
Active Trials
NCT01317134Completed90Est. Jul 2016
Third Pole Therapeutics
1 program
Inhaled Nitric OxideN/A1 trial
Active Trials
NCT05867914Active Not Recruiting5Est. Mar 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
BayerRiociguat
BayerRiociguat
BayerRiociguat
BayerRiociguat
United Therapeuticstreprostinil sodium
United Therapeuticstreprostinil sodium
Merck & Co.Riociguat
BayerRiociguat
Eli Lilly and CompanyTadalafil
BayerIloprost
Gilead Sciencesambrisentan
BayerRiociguat
BayerRiociguat
BayerVentavis
BayerRiociguat

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 13,981 patients across 50 trials

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Start: Jan 2017Est. completion: Mar 2020225 patients
Phase 4Completed

A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.

Start: Jun 2016Est. completion: Sep 202518 patients
Phase 4Completed

Upfront Combination Pulmonary Arterial Hypertension Therapy

Start: Apr 2016Est. completion: Jan 202120 patients
Phase 4Unknown

Measuring Outcomes In Patients With Pulmonary Arterial Hypertension Not on Active Treatment (MOTION)

Start: Sep 2014Est. completion: Jul 201675 patients
Phase 4Completed

Rapid Switch From Flolan to Remodulin in the Outpatient Clinic

Start: Mar 2008Est. completion: Feb 20127 patients
Phase 4Terminated

Transitioning To IV Remodulin From Ventavis in Patients With PAH: Safety, Efficacy and Treatment Satisfaction

Start: Mar 2007Est. completion: Nov 200710 patients
Phase 4Terminated

Riociguat in Children With Pulmonary Arterial Hypertension (PAH)

Start: Oct 2015Est. completion: Aug 202724 patients
Phase 3Active Not Recruiting

Riociguat Clinical Effects Studied in Patients With Insufficient Treatment Response to Phosphodiesterase-5 Inhibitor

Start: Feb 2014Est. completion: Dec 201661 patients
Phase 3Completed

A Study of Tadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH)

Start: Feb 2014Est. completion: Mar 202135 patients
Phase 3Completed

Inhaled Iloprost (Ventavis): Efficacy, Safety, and Pharmacokinetics (PK) Confirmation Study

Start: Jun 2012Est. completion: Dec 201627 patients
Phase 3Completed

A Study of First-Line Ambrisentan and Tadalafil Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Start: Oct 2010Est. completion: Jul 2014610 patients
Phase 3Completed

BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension

Start: Jul 2009Est. completion: Aug 2019237 patients
Phase 3Completed

BAY63-2521:Long-term Extension Study in Patients With Pulmonary Arterial Hypertension

Start: Mar 2009Est. completion: Aug 2019396 patients
Phase 3Completed

Safety Follow-up Study of Inhaled Iloprost in Patients With Pulmonary Hypertension

Start: Feb 2000Est. completion: Aug 200571 patients
Phase 3Completed

THERAPY-HYBRID-BPA Trial

Start: Oct 2020Est. completion: Jan 202572 patients
Phase 2Unknown

Coronary Vasomotor Response After Riociguat Exposure

Start: May 2012Est. completion: Jan 20130
Phase 2Withdrawn

Impact of Multiple Doses of BAY63-2521 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Patients With Interstitial Lung Disease (ILD) Associated Pulmonary Hypertension (PH)

Start: Aug 2008Est. completion: Jul 202522 patients
Phase 2Completed

An Open Multiple Dose Titration Study In Patients With Pulmonary Hypertension

Start: Jan 2007Est. completion: Sep 201475 patients
Phase 2Completed

Safety of Terbogrel in Patients With Primary Pulmonary Hypertension

Start: Oct 199833 patients
Phase 2Terminated

Aerosolized Randomized Iloprost Study II (AIR - II) Long-Term Safety, Tolerability, and Clinical Effects of Iloprost Inhalation in Patients With Primary or Secondary Pulmonary Hypertension

Start: Jul 1998Est. completion: May 200163 patients
Phase 2Completed

Safety and Efficacy of Terbogrel in Patients With Primary Pulmonary Hypertension

Start: May 199871 patients
Phase 2Completed

This Study Tests the Safety of Inhaled BAY1237592, How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Start: Jan 2019Est. completion: Nov 202238 patients
Phase 1Completed

Interaction With HIV Antiretroviral Agents

Start: Feb 2016Est. completion: Dec 201640 patients
Phase 1Completed

Microgynon Riociguat Drug Interaction Study in Healthy Postmenopausal Women

Start: Jun 2014Est. completion: Jul 201531 patients
Phase 1Completed

Relative Bioavailability Study

Start: Jun 2014Est. completion: Jan 201548 patients
Phase 1Completed

Relative Bioavailability and Food Effect Study

Start: Jan 2012Est. completion: May 201232 patients
Phase 1Completed

Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Impaired Liver Function and Healthy Participants Matched for Age-, Gender-, and Weight

Start: Apr 2010Est. completion: Sep 201132 patients
Phase 1Completed
NCT00963027United TherapeuticsTreprostinil diethanolamine

Effect of Esomeprazole on the Pharmacokinetics of Oral Treprostinil

Start: Sep 2009Est. completion: Oct 200930 patients
Phase 1Completed
NCT00963001United TherapeuticsTreprostinil diethanolamine

Effect of Food on the Pharmacokinetics of Oral Treprostinil

Start: Sep 2009Est. completion: Nov 200932 patients
Phase 1Completed

Interaction Study in Patients With Pulmonary Hypertension and Stable Treatment of Sildenafil 20 mg TID

Start: Oct 2008Est. completion: Nov 20097 patients
Phase 1Completed

Single Dose Study in Patients With Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension.

Start: Aug 2008Est. completion: Sep 200923 patients
Phase 1Completed

Riociguat in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

N/ANo Longer Available
NCT07087613Eko DevicesEko CORE 500 Digital Stethoscope

Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG

Start: Jun 2025Est. completion: Aug 20263,850 patients
N/ARecruiting

Early Feasibility Study Evaluating the 3P-100 Device in Subjects With PH-ILD

Start: Dec 2023Est. completion: Mar 20245 patients
N/AActive Not Recruiting

A Study to Learn About How Well Riociguat Works, How Safe it is and How it is Used Under Real World Conditions in Patients in the United States Who Are Receiving Riociguat for High Blood Pressure in the Arteries That Carry Blood From the Heart to the Lungs (Pulmonary Arterial Hypertension, PAH)

Start: Jul 2021Est. completion: Feb 2025500 patients
N/ACompleted

Evaluation of Inhaled Iloprost Effects Using the Breelib Nebulizer, on Clinical Outcomes and Physical Activity of Patients With Advanced Pulmonary Arterial Hypertension

Start: Feb 2018Est. completion: Jan 202031 patients
N/ACompleted

Examination of Ventavis (Iloprost) Inhalation Behavior Using the I-Neb AAD System in Patients With Pulmonary Arterial Hypertension When Switching the Iloprost Nebulizer Solution for Inhalation From 10 μg/mL (V10) to 20 μg/mL (V20)

Start: Sep 2016Est. completion: Jan 201764 patients
N/ACompleted

Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Start: Aug 2016Est. completion: Sep 2023282 patients
N/ACompleted
NCT02576002BayerAssigned pulmonary hypertension medication

Epidemiology and Treatment Patterns of Paediatric PAH (Pulmonary Arterial Hypertension)

Start: Oct 2015Est. completion: Jan 20162,691 patients
N/ACompleted

A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice

Start: Sep 2015Est. completion: Aug 2016125 patients
N/ACompleted
NCT02536534BayerCorrelation assessment

Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension

Start: Jun 2015Est. completion: Dec 201635 patients
N/ACompleted

Prospective, Non-interventional, Multi-center, Post-authorization Safety Study of Riociguat for Pulmonary Arterial Hypertension (PAH)

Start: Jun 2015Est. completion: Sep 2023882 patients
N/ACompleted

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH )

Start: Jul 2014Est. completion: Sep 20231,298 patients
N/ACompleted

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension

Start: May 2014Est. completion: Jun 20181,316 patients
N/ACompleted

Non-interventional Multi-center Study on Patients Under Routine Treatment of Pulmonary Arterial Hypertension (PAH) With Inhaled Iloprost Using I-Neb as a Device for Inhalation

Start: Sep 2013Est. completion: Apr 201713 patients
N/ACompleted

Observational Description of Compliance for the Daily Ventavis Use Via the Insight Program in Class III Pulmonary Arterial Hypertension Patients

Start: Sep 2013Est. completion: Jan 201717 patients
N/ACompleted

Iloprost Therapy in Patients With Critical Limb Ischemia

Start: Aug 2011Est. completion: Dec 2014126 patients
N/ACompleted

Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years

Start: Feb 2011Est. completion: Jun 2018118 patients
N/ACompleted
NCT01317134PfizerEndoPAT measurement

Endothelial Function in Patients With Pulmonary Arterial Hypertension

Start: Oct 2010Est. completion: Jul 201690 patients
N/ACompleted

Effect of BMPR-2 Gene Mutations on Hemodynamic Response by Iloprost Inhalation in Pulmonary Arterial Hypertension

Start: Oct 2010Est. completion: Dec 201873 patients
N/ACompleted

Related Jobs in Cardiovascular

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 13,981 patients
10 companies competing in this space