HER2-expressing Cancers
Oncology
4
Pipeline Programs
3
Companies
3
Clinical Trials
0
Approved Products
Pipeline by Development Stage
Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
2
0
0
0
0
Early DiscoveryClinical DevelopmentMarket
Drug Modality Breakdown
Monoclonal Antibody
2100%
+ 2 programs with unclassified modality
Competitive Landscape
3 companies ranked by most advanced pipeline stage
Jazz PharmaceuticalsCA - Palo Alto
2 programs1
1
ZanidatamabPhase 1/2Monoclonal Antibody
ZW25Phase 11 trial
Active Trials
Trial Timeline
Clinical trial activity over time
2021
2022
2023
2024
2025
2026
ALX OncologyZanidatamab
ZymeworksZW49
Jazz PharmaceuticalsZW25
Clinical Trials (3)
Total enrollment: 331 patients across 3 trials
A Study of Zanidatamab (ZW25) With Evorpacept (ALX148) in Patients With Advanced HER2-expressing Cancer
Start: Sep 2021Est. completion: Sep 202552 patients
Phase 1/2Completed
A Dose Finding Study of ZW49 in Patients With HER2-Positive Cancers
Start: Apr 2019Est. completion: Oct 2024
Phase 1Completed
Trial of ZW25 (Zanidatamab) in Patients With Advanced HER2-expressing Cancers
Start: Sep 2016Est. completion: Oct 2024279 patients
Phase 1Completed
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Phase Legend
Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available
Key Insights
3 companies competing in this space