Head and Neck Cancer

Oncology
36
Pipeline Programs
30
Companies
50
Clinical Trials
5 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
16
3
12
0
3
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
583%
Small Molecule
117%
+ 40 programs with unclassified modality

On Market (1)

Approved therapies currently available

U
EVOXACApproved
cevimeline hydrochloride
Unknown Company
oral2000

Competitive Landscape

33 companies ranked by most advanced pipeline stage

Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
3 programs
1
Erbitux®Phase 41 trial
MSOT Acuity Echo deviceN/A1 trial
tissue retractorsN/A1 trial
Active Trials
NCT04437030Completed30Est. Jul 2023
NCT04454697Completed34Est. Oct 2023
NCT01553032Completed139Est. May 2017
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
2 programs
1
1
porfiromycinPhase 31 trial
Afatinib, Ribavirin, and weekly carboplatin/paclitaxelPhase 11 trial
Active Trials
NCT01721525Completed10Est. Oct 2017
NCT00003328Completed600
AN
1 program
1
Buparlisib & PaclitaxelPhase 31 trial
Active Trials
NCT04338399CompletedEst. Nov 2025
DS
Daiichi SankyoChina - Shanghai
1 program
1
cevimeline hydrochloridePhase 31 trial
Active Trials
NCT00017511CompletedEst. Mar 2003
Providence Therapeutics
4 programs
2
1
1
PembrolizumabPhase 2Monoclonal Antibody1 trial
NivolumabPhase 1/2Monoclonal Antibody1 trial
Anti-OX40 antibody administrationPhase 11 trial
MEDI0562Phase 11 trial
Active Trials
NCT02274155CompletedEst. Dec 2023
NCT03336606Active Not RecruitingEst. Dec 2026
NCT03247712Active Not RecruitingEst. Dec 2026
+1 more trials
ALX Oncology
2 programs
2
evorpaceptPhase 2
evorpaceptPhase 2
Aveta Biomics
1 program
1
APG-157Phase 21 trial
Active Trials
NCT05312710Active Not RecruitingEst. Dec 2026
Heron Therapeutics
1 program
1
Drug: B10 L-BPA InjectionPhase 21 trial
Active Trials
NCT06952868RecruitingEst. Feb 2027
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
GefitinibPhase 2Small Molecule1 trial
Active Trials
NCT00095836Completed27Est. Mar 2011
Genentech
GenentechCA - Oceanside
1 program
1
MEHD7945APhase 21 trial
Active Trials
NCT01577173Completed122Est. Jun 2015
Nektar Therapeutics
Nektar TherapeuticsSAN FRANCISCO, CA
1 program
1
NKTR-214Phase 21 trial
Active Trials
NCT04936841TerminatedEst. Oct 2022
Innogene Kalbiotech
1
NimotuzumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT00702481CompletedEst. Sep 2019
Sanofi
SanofiPARIS, France
1 program
1
Oxaliplatin, 5-FUPhase 21 trial
Active Trials
NCT00611754Completed15Est. Feb 2003
ImmunityBio
ImmunityBioSAN DIEGO, CA
1 program
1
PD-L1 t-haNKPhase 21 trial
Active Trials
NCT06239220RecruitingEst. Jan 2027
Coherus Oncology
Coherus OncologyCA - Redwood City
1 program
1
Toripalimab + ChemotherapyPhase 21 trial
Active Trials
NCT07209189Recruiting75Est. Dec 2030
Abbott
AbbottABBOTT PARK, IL
1 program
1
ABT-510Phase 1/21 trial
Active Trials
NCT00113334Completed6Est. Mar 2008
Alentis Therapeutics
Alentis TherapeuticsSwitzerland - Allschwil
1 program
1
ALE.C04Phase 1/21 trial
Active Trials
NCT06054477TerminatedEst. Feb 2025
Bristol Myers Squibb
2 programs
1
CetuximabPhase 1Monoclonal Antibody1 trial
Head and Neck Cancer Treatment Patterns and Outcomes Research Study in France, Germany, and CanadaN/A1 trial
Active Trials
NCT02705833Completed591Est. Dec 2016
NCT00882583Terminated22Est. Feb 2016
T-Therapeutics
2 programs
1
DichloroacetatePhase 11 trial
TadalafilN/A1 trial
Active Trials
NCT00843635CompletedEst. Apr 2015
NCT01163487CompletedEst. Feb 2016
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
2 programs
1
PemetrexedPhase 11 trial
Therapy for head and neck cancerN/A1 trial
Active Trials
NCT01080313Completed26,000Est. Dec 2011
NCT00507858Completed36Est. Sep 2011
Curis
CurisMA - Lexington
2 programs
2
CUDC-101Phase 11 trial
CUDC-101Phase 11 trial
Active Trials
NCT01171924CompletedEst. Oct 2011
NCT01384799CompletedEst. Oct 2013
Roche
RocheSTAVANGER NORWAY, Norway
2 programs
2
RO5083945Phase 11 trial
erlotinib hydrochloridePhase 11 trial
Active Trials
NCT01046266Completed62Est. Jun 2012
NCT00079053Completed19Est. Jan 2011
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
ABBV-181Phase 15 trials
Active Trials
NCT07241039Recruiting220Est. Oct 2030
NCT06158958Terminated27Est. Oct 2025
NCT04223804Completed41Est. Feb 2023
+2 more trials
Cellectar Biosciences
Cellectar BiosciencesFLORHAM PARK, NJ
1 program
1
CLR 131Phase 11 trial
Active Trials
NCT04105543CompletedEst. Feb 2024
Cue Biopharma
Cue BiopharmaBOSTON, MA
1 program
1
CUE-101Phase 11 trial
Active Trials
NCT03978689Completed80Est. Jan 2026
Regeneron
RegeneronTARRYTOWN, NY
1 program
1
CisplatinPhase 11 trial
Active Trials
NCT04722523Recruiting40Est. Jun 2026
Astex Pharmaceuticals
Astex PharmaceuticalsUK - Cambridge
1 program
1
Oral DecitabinePhase 1
Arcus Biosciences
1 program
1
ZimberelimabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT04892875WithdrawnEst. Dec 2026
Varian Medical Systems
2 programs
RadiotherapyN/A1 trial
Ring gantry kV-CBCT combined with linear acceleratorN/A1 trial
Active Trials
NCT01011842TerminatedEst. Nov 2011
NCT04379505CompletedEst. Dec 2023
Tactile Medical
Tactile MedicalMN - Minneapolis
1 program
Flexitouch Plus systemN/A1 trial
Active Trials
NCT04276454WithdrawnEst. Apr 2020

+3 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Heidelberg PharmaErbitux®
Adlai NortyeBuparlisib & Paclitaxel
Daiichi Sankyocevimeline hydrochloride
Boehringer Ingelheimporfiromycin
Coherus OncologyToripalimab + Chemotherapy
Heron TherapeuticsDrug: B10 L-BPA Injection
ImmunityBioPD-L1 t-haNK
Aveta BiomicsAPG-157
Providence TherapeuticsPembrolizumab
Nektar TherapeuticsNKTR-214
GenentechMEHD7945A
Innogene KalbiotechNimotuzumab
AstraZenecaGefitinib
SanofiOxaliplatin, 5-FU
Alentis TherapeuticsALE.C04

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 3,333 patients across 50 trials

Skin Changes in Head and Neck Cancer During Immuno-(Chemo-) And Radiotherapy With Erbitux® (HICARE)

Start: Jun 2011Est. completion: May 2017139 patients
Phase 4Completed
NCT04338399Adlai NortyeBuparlisib & Paclitaxel

The BURAN Study of Buparlisib in Patients With Recurrent or Metastatic HNSCC

Start: Dec 2020Est. completion: Nov 2025
Phase 3Completed
NCT00017511Daiichi Sankyocevimeline hydrochloride

Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer

Start: Jun 2001Est. completion: Mar 2003
Phase 3Completed

Radiation Therapy Plus Porfiromycin in Treating Patients With Stage III or Stage IV Head and Neck Cancer

Start: Dec 1997600 patients
Phase 3Completed
NCT07209189Coherus OncologyToripalimab + Chemotherapy

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

Start: Mar 2026Est. completion: Dec 203075 patients
Phase 2Recruiting
NCT06952868Heron TherapeuticsDrug: B10 L-BPA Injection

Boron Neutron Capture Therapy With B10 L-BPA for Unresectable Recurrent Head and Neck Cancers

Start: May 2025Est. completion: Feb 2027
Phase 2Recruiting

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

Start: Feb 2024Est. completion: Jan 2027
Phase 2Recruiting

Safety and Efficacy of APG-157 in Head and Neck Cancer

Start: Apr 2022Est. completion: Dec 2026
Phase 2Active Not Recruiting

Neoadjuvant Immunoradiotherapy in Head & Neck Cancer (NIRT 2-HNC)

Start: Jan 2022Est. completion: Jan 2031
Phase 2Active Not Recruiting

Bempegaldesleukin (NKTR-214) With Radiation and Anti-PD-1 Immunotherapy for Head and Neck Squamous Cell Carcinoma

Start: Aug 2021Est. completion: Oct 2022
Phase 2Terminated

A Study of MEHD7945A Versus Cetuximab in Patients With Recurrent/Metastatic Squamous Cell Carcinoma of The Head And Neck

Start: Jul 2012Est. completion: Jun 2015122 patients
Phase 2Completed

Study of Nimotuzumab and Cisplatin/Radiotherapy for Locally Advanced Head and Neck Squamous Cell Cancer

Start: Apr 2008Est. completion: Sep 2019
Phase 2Completed

Gefitinib in Treating Patients With Locally Advanced or Metastatic Thyroid Cancer That Did Not Respond to Iodine Therapy

Start: Mar 2003Est. completion: Mar 201127 patients
Phase 2Completed
NCT00611754SanofiOxaliplatin, 5-FU

Phase II Study of Oxaliplatin in Combination With 5-Fu in 1st Line Treatment of Locally Advanced or Metastatic Squamous Cell Carcinoma of the Head and Neck

Start: May 2000Est. completion: Feb 200315 patients
Phase 2Completed

Study of ALE.C04 in Patients With Head and Neck Cancer

Start: Oct 2023Est. completion: Feb 2025
Phase 1/2Terminated

Neoadjuvant Immunoradiotherapy in Head & Neck Cancer

Start: Jan 2018Est. completion: Dec 2026
Phase 1/2Active Not Recruiting

Study of ABT-510 (Thrombospondin Analogue) in Patients With Advanced Head and Neck Cancer

Start: Apr 2005Est. completion: Mar 20086 patients
Phase 1/2Completed

A Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous Tumors

Start: Nov 2025Est. completion: Oct 2030220 patients
Phase 1Recruiting

A Study to Assess the Safety, Pharmacokinetics, and Efficacy of Intravenous (IV) ABBV-303, as Monotherapy and in Combination With IV Infused Budigalimab (ABBV-181), in Adults With Advanced Solid Tumors

Start: Feb 2024Est. completion: Oct 202527 patients
Phase 1Terminated

A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor / Adenosine 2b Receptor Inhibitor AB928 Therapies in Locally Advanced Head and Neck Cancers

Start: Dec 2023Est. completion: Dec 2026
Phase 1Withdrawn

A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer

Start: Jan 2021Est. completion: Jun 202640 patients
Phase 1Recruiting

A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of ABBV-181 (Budigalimab) in Adult Participants With Human Immunodeficiency Virus (HIV)-1

Start: Jan 2020Est. completion: Feb 202341 patients
Phase 1Completed

A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-368 Plus Tilsotolimod and Other Therapy Combinations in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Start: Jan 2020Est. completion: Oct 202230 patients
Phase 1Completed

A Study to Assess the Effects of Multiple Study Drug Regimens in Subjects With Newly Diagnosed Locally Advanced Head and Neck Squamous Cell Carcinoma

Start: Jan 2020Est. completion: Sep 20203 patients
Phase 1Terminated

CLR 131 Combined With Radiation for Head and Neck Cancer

Start: Dec 2019Est. completion: Feb 2024
Phase 1Completed

A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma

Start: Jul 2019Est. completion: Jan 202680 patients
Phase 1Completed

A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

Start: May 2019Est. completion: Mar 2026150 patients
Phase 1Active Not Recruiting

Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors

Start: Feb 2019Est. completion: Jun 2027364 patients
Phase 1Active Not Recruiting

A Study of ABBV-011 Alone and in Combination With Budigalimab (ABBV-181) in Participants With Relapsed or Refractory Small Cell Lung Cancer

Start: Oct 2018Est. completion: Jan 2024132 patients
Phase 1Completed

Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma

Start: Jul 2018Est. completion: Dec 2026
Phase 1Active Not Recruiting

SC-004 Alone or With ABBV-181 in Subjects With Epithelial Ovarian, Fallopian Tube, Primary Peritoneal and Endometrial Cancers

Start: Jun 2017Est. completion: May 201924 patients
Phase 1Terminated

A Study of ABBV-927 and ABBV-181, an Immunotherapy, in Participants With Advanced Solid Tumors

Start: Feb 2017Est. completion: Sep 2026163 patients
Phase 1Active Not Recruiting
NCT02274155Providence TherapeuticsAnti-OX40 antibody administration

Anti-OX40 Antibody in Head and Neck Cancer Patients

Start: Nov 2014Est. completion: Dec 2023
Phase 1Completed

A Study of ABT-165 in Subjects With Solid Tumors

Start: Aug 2013Est. completion: Sep 2022101 patients
Phase 1Completed
NCT01721525Boehringer IngelheimAfatinib, Ribavirin, and weekly carboplatin/paclitaxel

Induction Chemotherapy With Afatinib, Ribavirin, and Weekly Carboplatin/Paclitaxel for Stage IVA/IVB HPV Associated Oropharynx Squamous Cell Cancer (OPSCC)

Start: Nov 2012Est. completion: Oct 201710 patients
Phase 1Completed

Phase I Study of CUDC-101 With Cisplatin and Radiation in Subjects With Head & Neck Cancer

Start: Nov 2011Est. completion: Oct 2013
Phase 1Completed

Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers

Start: Aug 2010Est. completion: Feb 2016
Phase 1Completed

A Phase Ib Expansion Study Investigating the Safety, Efficacy, and Pharmacokinetics of Intravenous CUDC-101 in Subjects With Advanced Head and Neck, Gastric, Breast, Liver and Non-small Cell Lung Cancer Tumors

Start: Jul 2010Est. completion: Oct 2011
Phase 1Completed

A Study of Pharmacodynamics of RO5083945 in Patients With Head and Neck Squamous Cell Carcinoma

Start: Nov 2009Est. completion: Jun 201262 patients
Phase 1Completed

A Study of Dasatinib, Cetuximab and Radiation With or Without Cisplatin in HNSCC

Start: Jul 2009Est. completion: Feb 201622 patients
Phase 1Terminated

Pemetrexed (Alimta) in Patients With Head and Neck Squamous Cell Cancer

Start: Sep 2005Est. completion: Sep 201136 patients
Phase 1Completed
NCT00079053Rocheerlotinib hydrochloride

Adjuvant Erlotinib After Completing Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck

Start: Mar 2004Est. completion: Jan 201119 patients
Phase 1Completed
NCT04379505Varian Medical SystemsRing gantry kV-CBCT combined with linear accelerator

Palliative Expeditiously Adaptive Quad Shot Radiation Therapy (PEAQ-RT)

Start: Oct 2020Est. completion: Dec 2023
N/ACompleted

Tissue Retractors for Radiation Therapy of Head and Neck Tumors

Start: Jul 2020Est. completion: Oct 202334 patients
N/ACompleted
NCT04437030Heidelberg PharmaMSOT Acuity Echo device

Multiparametric Photoacoustic Imaging in the Course of Radiation Therapy of Malignant Head and Neck Tumors

Start: Jul 2020Est. completion: Jul 202330 patients
N/ACompleted
NCT04276454Tactile MedicalFlexitouch Plus system

Lymphedema Treatment in Head and Neck Cancer Patients

Start: Apr 2020Est. completion: Apr 2020
N/AWithdrawn
NCT02829489Fresenius KabiInternational Nutrition Audit in FORegut TuMors

International Nutrition Audit in FORegut TuMors

Start: Jul 2016Est. completion: Oct 2019170 patients
N/ACompleted
NCT02705833Bristol Myers SquibbHead and Neck Cancer Treatment Patterns and Outcomes Research Study in France, Germany, and Canada

Head and Neck Cancer Treatment Patterns and Outcomes Research Study in France, Germany, and Canada

Start: Dec 2015Est. completion: Dec 2016591 patients
N/ACompleted
NCT01946867NanobiotixNBTXR3 activated by IMRT

NBTXR3 and Radiation Therapy in Treating Patients With Locally Advanced SCC of the Oral Cavity or Oropharynx

Start: Jan 2014Est. completion: Feb 2023
N/AUnknown

Real-Time kV Imaging vs. Real-Time 3D Patient Surface Tracking for Head & Neck Cancer

Start: Oct 2009Est. completion: Nov 2011
N/ATerminated

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
5 actively recruiting trials targeting 3,333 patients
30 companies competing in this space