Glioblastoma

Oncology
60
Pipeline Programs
30
Companies
50
Clinical Trials
8 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
27
6
17
3
6
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
536%
Small Molecule
321%
RNA Therapeutic
214%
Vaccine
17%
Cell Therapy
17%
ADC
17%
Peptide
17%
+ 58 programs with unclassified modality

On Market (1)

Approved therapies currently available

M&
TEMODARApproved
temozolomide
Merck & Co.
Alkylating Drug [EPC]intravenous2009

Competitive Landscape

39 companies ranked by most advanced pipeline stage

M&
Merck & Co.RAHWAY, NJ
3 programs
1
1
1
CilengitidePhase 2Peptide2 trials
PembrolizumabPhase 1Monoclonal Antibody1 trial
TemozolomideN/A1 trial
Active Trials
NCT00725010Completed64Est. Apr 2009
NCT03426891Completed21Est. Jun 2023
NCT01118676CompletedEst. Apr 2015
+1 more trials
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
5 programs
1
1
TemozolomidePhase 31 trial
Temozolomide in both armsPhase 21 trial
Proton irradiationN/A1 trial
Re-resectionN/A1 trial
Supramaximal resectionN/A1 trial
Active Trials
NCT04752280Recruiting326Est. Jan 2033
NCT06283927Recruiting464Est. Jan 2028
NCT06118723Recruiting784Est. Jan 2028
+2 more trials
Pfizer
PfizerNEW YORK, NY
4 programs
1
1
2
EdotecarinPhase 31 trial
Tofacitinib 10mgPhase 31 trial
Temodar and IrinotecanPhase 21 trial
SU011248 & IrinotecanPhase 11 trial
Active Trials
NCT00611728Completed25Est. Sep 2010
NCT00616005Completed41Est. Jun 2009
NCT00068952Completed118Est. Mar 2006
+1 more trials
Celldex Therapeutics
3 programs
2
1
RindopepimutPhase 31 trial
BevacizumabPhase 2Monoclonal Antibody1 trial
Human CMV pp65-LAMP mRNA-pulsed autologous DCsPhase 2RNA Therapeutic1 trial
Active Trials
NCT01498328Completed127Est. May 2016
NCT03688178Active Not Recruiting43Est. Mar 2026
NCT01480479Completed745Est. Nov 2016
GC Biopharma
1 program
1
Activated T lymphocytePhase 31 trial
Active Trials
NCT00807027CompletedEst. Oct 2012
GT Biopharma
GT BiopharmaSAN FRANCISCO, CA
1 program
1
GammaTile®Phase 31 trial
Active Trials
NCT07195591RecruitingEst. Dec 2031
AstraZeneca
3 programs
2
1
TemozolomidePhase 2/3
AZD1390Phase 11 trial
Zactima, Gleevec, HydroxyureaPhase 11 trial
Active Trials
NCT05182905Active Not Recruiting97Est. Dec 2026
NCT00613054Completed27Est. Apr 2009
Biohaven
BiohavenNEW HAVEN, CT
2 programs
1
1
TemozolomidePhase 2/3
TroriluzolePhase 1Small Molecule1 trial
Active Trials
NCT06552260RecruitingEst. Aug 2027
Kazia Therapeutics
Kazia TherapeuticsAustralia - Sydney
2 programs
1
1
TemozolomidePhase 2/3
PaxalisibPhase 2Small Molecule1 trial
Active Trials
NCT05183204SuspendedEst. Jun 2026
Philogen
PhilogenItaly - Monteriggioni
4 programs
1
2
1
L19TNFPhase 21 trial
L19TNFPhase 1/21 trial
Onfekafusp alfaPhase 1/21 trial
Onfekafusp alfaPhase 11 trial
Active Trials
NCT05304663Withdrawn0Est. Dec 2024
NCT04573192Recruiting142Est. Dec 2025
NCT04443010Recruiting226Est. Dec 2026
+1 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
3 programs
2
1
BIBF 1120Phase 21 trial
BI 907828Phase 11 trial
TemozolomidePhase 11 trial
Active Trials
NCT05376800Completed24Est. Jul 2025
NCT00977431Completed36Est. Sep 2017
NCT01380782Completed37Est. Jul 2014
ImmunityBio
ImmunityBioSAN DIEGO, CA
2 programs
2
250 mg/m2 aldoxorubicinPhase 21 trial
BevacizumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT02014844Completed28Est. Dec 2016
NCT06061809Recruiting34Est. Dec 2030
Genentech
2 programs
2
Avastin and TemozolomidePhase 21 trial
Erlotinib HClPhase 21 trial
Active Trials
NCT00612339Completed41Est. May 2012
NCT00337883Completed110Est. Oct 2005
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
2 programs
2
DordavipronePhase 21 trial
NabiximolsPhase 21 trial
Active Trials
NCT02525692Terminated84Est. Apr 2023
NCT05629702Recruiting120Est. Apr 2027
Knight Therapeutics
Knight TherapeuticsQC - Montréal
1 program
1
FerumoxytolPhase 21 trial
Active Trials
NCT03347617Terminated52Est. Jun 2025
Cellectar Biosciences
1
I-124-CLR1404Phase 21 trial
Active Trials
NCT01898273TerminatedEst. Dec 2015
Karyopharm Therapeutics
1 program
1
SelinexorPhase 21 trial
Active Trials
NCT01986348TerminatedEst. Jan 2020
Bristol Myers Squibb
2 programs
1
1
DasatinibPhase 1/2Small Molecule1 trial
Anti-LAG-3 Monoclonal Antibody BMS 986016Phase 11 trial
Active Trials
NCT02658981Completed63Est. Oct 2023
NCT00948389Terminated28Est. May 2011
Transgene
TransgeneFrance - Illkirch-Graffenstaden
1 program
1
Combination of TG6002 and 5-flucytosinePhase 1/21 trial
Active Trials
NCT03294486UnknownEst. Sep 2021
MediciNova
MediciNovaLA JOLLA, CA
1 program
1
MN-166Phase 1/21 trial
Active Trials
NCT03782415Completed64Est. Aug 2023
Sapience Therapeutics
Sapience TherapeuticsNY - Tarrytown
1 program
1
ST101Phase 1/21 trial
Active Trials
NCT04478279Active Not RecruitingEst. Dec 2026
Novartis
NovartisBASEL, Switzerland
3 programs
3
PTK787/ZK 222584Phase 11 trial
[177Lu]Lu-DOTA-TATEPhase 11 trial
ceritinib 750mgPhase 1
Active Trials
NCT00385853Completed19Est. Sep 2011
NCT05109728Active Not Recruiting65Est. Jul 2027
IB
2
APVAC1 vaccine plus Poly-ICLC and GM-CSFPhase 1Vaccine1 trial
CyclophosphamidePhase 11 trial
Active Trials
NCT02149225Completed16Est. Jun 2018
NCT01403285Terminated6Est. Apr 2014
Genomics
GenomicsUK - Oxford
2 programs
2
AZD1775Phase 11 trial
ceritinib 750mgPhase 11 trial
Active Trials
NCT02207010Completed20Est. Mar 2019
NCT02605746Completed10Est. Jul 2019
GS
Gilead SciencesFOSTER CITY, CA
2 programs
2
CART-EGFR-IL13Ra2 CellsPhase 1Cell Therapy1 trial
Sacituzumab GovitecanPhase 1ADC1 trial
Active Trials
NCT05168423Active Not Recruiting67Est. Dec 2039
NCT03995706Completed26Est. Mar 2024
Regeneron
RegeneronTARRYTOWN, NY
1 program
1
ASP8374Phase 1
C
CureVacGermany - Tübingen
1 program
1
CV09050101 mRNA vaccinePhase 1RNA Therapeutic1 trial
Active Trials
NCT05938387CompletedEst. Feb 2026
BP
Basilea PharmaceuticaSwitzerland - Allschwil
1 program
1
Microtubule-Targeted Agent BAL101553Phase 11 trial
Active Trials
NCT03250299TerminatedEst. Aug 2022
REVOLUTION Medicines
1
RMC-5552Phase 11 trial
Active Trials
NCT05557292RecruitingEst. Apr 2030
EpicentRx
EpicentRxCA - La Jolla
1 program
1
RRx-001 dose escalation with TMZ + RTPhase 11 trial
Active Trials
NCT02871843CompletedEst. Sep 2021

+9 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
GT BiopharmaGammaTile®
PfizerTofacitinib 10mg
Celldex TherapeuticsRindopepimut
GC BiopharmaActivated T lymphocyte
Heidelberg PharmaTemozolomide
PfizerEdotecarin
ImmunityBioBevacizumab
PhilogenL19TNF
Jazz PharmaceuticalsNabiximols
Kazia TherapeuticsPaxalisib
Celldex TherapeuticsHuman CMV pp65-LAMP mRNA-pulsed autologous DCs
Knight TherapeuticsFerumoxytol
Jazz PharmaceuticalsDordaviprone
Karyopharm TherapeuticsSelinexor
ImmunityBio250 mg/m2 aldoxorubicin

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 3,373 patients across 50 trials

Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

Start: Dec 2025Est. completion: Dec 2031
Phase 3Recruiting
NCT05326464PfizerTofacitinib 10mg

Tofacitinib in Recurrent GBM Patients

Start: Oct 2022Est. completion: Jun 202717 patients
Phase 3Active Not Recruiting

Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma

Start: Nov 2011Est. completion: Nov 2016745 patients
Phase 3Completed
NCT00807027GC BiopharmaActivated T lymphocyte

Clinical Trial to Assess the Efficacy and Safety of 'Immuncell-LC' With Temozolomide in Newly Diagnosed Glioblastoma of Korea

Start: Dec 2008Est. completion: Oct 2012
Phase 3Completed

Phase III Trial of Primary Radio- or Chemotherapy in Malignant Astrocytoma of the Elderly

Start: Jan 2005Est. completion: Nov 2011412 patients
Phase 3Completed

Study of IV Edotecarin Vs Temozolomide or Carmustine (BCNU) or Lomustine (CCNU) in Patients With Glioblastoma Multiforme

Start: Aug 2003Est. completion: Mar 2006118 patients
Phase 3Completed

N-803 and PD-L1 t-haNK Combined With Bevacizumab for Recurrent or Progressive Glioblastoma

Start: Aug 2024Est. completion: Dec 203034 patients
Phase 2Recruiting

A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or Recurrence

Start: May 2024Est. completion: Jun 202690 patients
Phase 2Recruiting

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids

Start: Feb 2023Est. completion: Apr 2027120 patients
Phase 2Recruiting

Paxalisib With a High Fat, Low Carb Diet and Metformin for Glioblastoma

Start: Feb 2022Est. completion: Jun 2026
Phase 2Suspended
NCT03688178Celldex TherapeuticsHuman CMV pp65-LAMP mRNA-pulsed autologous DCs

DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab

Start: Aug 2020Est. completion: Mar 202643 patients
Phase 2Active Not Recruiting

Ferumoxytol MRI in Assessing Response to Pembrolizumab in Patients With Glioblastoma

Start: Dec 2017Est. completion: Jun 202552 patients
Phase 2Terminated

Oral ONC201 in Adult Recurrent Glioblastoma

Start: Jan 2016Est. completion: Apr 202384 patients
Phase 2Terminated

Study Evaluating the Efficacy and Safety of Selinexor (KPT-330) in Participants With Recurrent Gliomas

Start: Mar 2014Est. completion: Jan 2020
Phase 2Terminated
NCT02014844ImmunityBio250 mg/m2 aldoxorubicin

Phase 2 Study to Investigate the Efficacy and Safety of Aldoxorubicin in Subjects With Glioblastoma

Start: Mar 2014Est. completion: Dec 201628 patients
Phase 2Completed

Imaging Trial With I-124-CLR1404 in Patients With Newly Diagnosed or Recurrent Glioblastoma

Start: Feb 2014Est. completion: Dec 2015
Phase 2Terminated

BIBF 1120 for Recurrent High-Grade Gliomas

Start: May 2012Est. completion: Jul 201437 patients
Phase 2Completed

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma

Start: Dec 2011Est. completion: May 2016127 patients
Phase 2Completed
NCT00941460Heidelberg PharmaTemozolomide in both arms

Comparison of Two Dosing Regimens of Temozolomide in Patients With Progressive or Recurrent Glioblastoma

Start: Sep 2009Est. completion: Jun 2013105 patients
Phase 2Completed

Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status

Start: Mar 2009Est. completion: Aug 2013265 patients
Phase 2Completed
NCT00612339GenentechAvastin and Temozolomide

Avastin in Combination With Temozolomide for Unresectable or Multifocal GBMs and Gliosarcomas

Start: Aug 2007Est. completion: May 201241 patients
Phase 2Completed
NCT00616005PfizerTemodar and Irinotecan

Ph. II Treatment of Adults w Primary Malignant Glioma w Irinotecan + Temozolomide

Start: Nov 2005Est. completion: Jun 200941 patients
Phase 2Completed

A Study of the Safety and Efficacy of Tarceva in Patients With First Relapse of Grade IV Glioma (Glioblastoma Multiforme)

Start: Jul 2003Est. completion: Oct 2005110 patients
Phase 2Completed

A Study to Evaluate Safety and Efficacy of L19TNF Plus Lomustine in Patients With Glioblastoma at First Progression

Start: Feb 2021Est. completion: Dec 2025142 patients
Phase 1/2Recruiting
NCT04443010PhilogenOnfekafusp alfa

Safety and Efficacy of L19TNF Plus Temozolomide Chemoradiotherapy in Patients With Newly Diagnosed Glioblastoma

Start: Jan 2021Est. completion: Dec 2026226 patients
Phase 1/2Recruiting

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Start: Jul 2020Est. completion: Dec 2026
Phase 1/2Active Not Recruiting

Study to Evaluate Ibudilast and TMZ Combo Treatment in Newly Diagnosed and Recurrent Glioblastoma

Start: Dec 2018Est. completion: Aug 202364 patients
Phase 1/2Completed
NCT03294486TransgeneCombination of TG6002 and 5-flucytosine

Safety and Efficacy of the ONCOlytic VIRus Armed for Local Chemotherapy, TG6002/5-FC, in Recurrent Glioblastoma Patients

Start: Oct 2017Est. completion: Sep 2021
Phase 1/2Unknown

Study of CCNU (Lomustine) Plus Dasatinib in Recurrent Glioblastoma (GBM)

Start: Oct 2009Est. completion: May 201128 patients
Phase 1/2Terminated

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

Start: Feb 2025Est. completion: Aug 2027
Phase 1Recruiting
NCT05938387CureVacCV09050101 mRNA vaccine

Safety and Tolerability of CVGBM in Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma or Astrocytoma

Start: Jun 2023Est. completion: Feb 2026
Phase 1Completed

RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma

Start: Apr 2023Est. completion: Apr 2030
Phase 1Recruiting
NCT05168423Gilead SciencesCART-EGFR-IL13Ra2 Cells

CART-EGFR-IL13Ra2 in EGFR Amplified Recurrent GBM

Start: Feb 2023Est. completion: Dec 203967 patients
Phase 1Active Not Recruiting

A Study to Determine How BI 907828 (Brigimadlin) is Taken up in the Tumor (Phase 0) and to Determine the Highest Dose of BI 907828 (Brigimadlin) That Could be Tolerated (Phase 1a) in Combination With Radiation Therapy in People With a Brain Tumor Called Glioblastoma

Start: Nov 2022Est. completion: Jul 202524 patients
Phase 1Completed
NCT05304663PhilogenOnfekafusp alfa

Safety and Efficacy of Different Administration Sequences of L19TNF With Lomustine in Glioblastoma at First Progression

Start: Jun 2022Est. completion: Dec 20240
Phase 1Withdrawn

AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients

Start: May 2022Est. completion: Dec 202697 patients
Phase 1Active Not Recruiting
NCT05109728Novartis[177Lu]Lu-DOTA-TATE

A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.

Start: May 2022Est. completion: Jul 202765 patients
Phase 1Active Not Recruiting

AB154 Combined With AB122 for Recurrent Glioblastoma

Start: Apr 2021Est. completion: Dec 2026
Phase 1Active Not Recruiting

Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM

Start: Dec 2019Est. completion: Feb 2022
Phase 1Terminated
NCT03995706Gilead SciencesSacituzumab Govitecan

Neuro/Sacituzumab Govitecan/Breast Brain Metastasis/Glioblastoma/Ph 0

Start: Jul 2019Est. completion: Mar 202426 patients
Phase 1Completed

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

Start: Mar 2018Est. completion: Jun 202321 patients
Phase 1Completed
NCT03231501Hutchmedepitinib succinate

HMPL-813 in Treating Patients With Glioblastoma

Start: Jan 2018Est. completion: Aug 202029 patients
Phase 1Unknown
NCT03250299Basilea PharmaceuticaMicrotubule-Targeted Agent BAL101553

Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Start: Dec 2017Est. completion: Aug 2022
Phase 1Terminated
NCT02871843EpicentRxRRx-001 dose escalation with TMZ + RT

RRx-001 + Radiation + Temozolomide In Newly Diagnosed Glioblastoma and Anaplastic Gliomas

Start: Feb 2017Est. completion: Sep 2021
Phase 1Completed
NCT02658981Bristol Myers SquibbAnti-LAG-3 Monoclonal Antibody BMS 986016

Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)

Start: Aug 2016Est. completion: Oct 202363 patients
Phase 1Completed
NCT02605746Genomicsceritinib 750mg

Preoperative Ceritinib (LDK378) in Glioblastoma Multiforme and CNS Metastasis

Start: Feb 2016Est. completion: Jul 201910 patients
Phase 1Completed
NCT02149225Immatics BiotechnologiesAPVAC1 vaccine plus Poly-ICLC and GM-CSF

GAPVAC Phase I Trial in Newly Diagnosed Glioblastoma Patients

Start: Oct 2014Est. completion: Jun 201816 patients
Phase 1Completed

A Phase 0 Study of AZD1775 in Recurrent GBM Patients

Start: Jul 2014Est. completion: Mar 201920 patients
Phase 1Completed

Peptide-based Glioma Vaccine IMA950 in Patients With Glioblastoma

Start: Aug 2011Est. completion: Apr 20146 patients
Phase 1Terminated

Cilengitide Together With Radiochemotherapy in Patients With Locally Advanced Non Small Cell Lung Cancer

Start: Mar 2010Est. completion: Apr 2015
Phase 1Completed

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

6 late-stage (Phase 3) programs — potential near-term approvals
8 actively recruiting trials targeting 3,373 patients
30 companies competing in this space