Ewing Sarcoma

Oncology
5
Pipeline Programs
5
Companies
10
Clinical Trials
6 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
3
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 4 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Salarius Pharmaceuticals
2 programs
1
1
SeclidemstatPhase 1/2Small Molecule1 trial
SeclidemstatPhase 1Small Molecule1 trial
Active Trials
NCT03600649Unknown50Est. Dec 2025
NCT05266196Unknown10Est. Dec 2025
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
1 program
1
LurbinectedinPhase 1/21 trial
Active Trials
NCT05918640Recruiting63Est. Jul 2028
Alliance Pharmaceuticals
1 program
1
Trabectedin 1 MG [Yondelis]Phase 1/2
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
XaluritamigPhase 15 trials
Active Trials
NCT07297979Recruiting50Est. May 2030
NCT07213674Recruiting750Est. Aug 2032
NCT07140900Recruiting60Est. Mar 2030
+2 more trials
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
Drug Sensitivity and Mutation ProfilingN/A1 trial
Active Trials
NCT04956198CompletedEst. Dec 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
AmgenXaluritamig
AmgenXaluritamig
Jazz PharmaceuticalsLurbinectedin
Salarius PharmaceuticalsSeclidemstat
AmgenXaluritamig
AmgenXaluritamig
AmgenXaluritamig
AmgenXaluritamig
Salarius PharmaceuticalsSeclidemstat
T-TherapeuticsDrug Sensitivity and Mutation Profiling

Clinical Trials (10)

Total enrollment: 1,748 patients across 10 trials

NCT07213674AmgenXaluritamig

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

Start: Nov 2025Est. completion: Aug 2032750 patients
Phase 3Recruiting
NCT06691984AmgenXaluritamig

Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Participants With Progressive Metastatic Castration-Resistant Prostate Cancer (XALute)

Start: Dec 2024Est. completion: Jul 2029675 patients
Phase 3Recruiting
NCT05918640Jazz PharmaceuticalsLurbinectedin

Lurbinectedin in FET-Fused Tumors

Start: Jul 2023Est. completion: Jul 202863 patients
Phase 1/2Recruiting
NCT05266196Salarius PharmaceuticalsSeclidemstat

A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577)

Start: Jan 2022Est. completion: Dec 202510 patients
Phase 1/2Unknown
NCT07297979AmgenXaluritamig

Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

Start: Apr 2026Est. completion: May 203050 patients
Phase 1Recruiting
NCT07140900AmgenXaluritamig

Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer

Start: Oct 2025Est. completion: Mar 203060 patients
Phase 1Recruiting
NCT06613100AmgenXaluritamig

Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer

Start: Nov 2024Est. completion: Jan 203040 patients
Phase 1Recruiting
NCT06555796AmgenXaluritamig

Evaluation of Xaluritamig in High-Risk, Biochemically Recurrent, Non-metastatic Castrate-sensitive Prostate Cancer

Start: Sep 2024Est. completion: Dec 202850 patients
Phase 1Active Not Recruiting
NCT03600649Salarius PharmaceuticalsSeclidemstat

Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas

Start: Jun 2018Est. completion: Dec 202550 patients
Phase 1Unknown
NCT04956198T-TherapeuticsDrug Sensitivity and Mutation Profiling

Drug Sensitivity and Mutation Profiling

Start: Nov 2020Est. completion: Dec 2022
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

6 actively recruiting trials targeting 1,748 patients
5 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)