Coronary Occlusion

Cardiovascular
2
Pipeline Programs
2
Companies
17
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Abbott
AbbottABBOTT PARK, IL
1 program
1
Percutaneous coronary interventionPhase 45 trials
Active Trials
NCT07114393Recruiting11,092Est. May 2027
NCT06736665Not Yet Recruiting50Est. Dec 2026
NCT04475380Completed1,757Est. Dec 2025
+2 more trials
Reflow Medical
Reflow MedicalCA - San Clemente
1 program
1
coraFlex CatheterPhase 31 trial
Active Trials
NCT05848232Unknown150Est. Feb 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
Reflow MedicalcoraFlex Catheter
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention
AbbottPercutaneous coronary intervention

Showing 15 of 17 trials with date data

Clinical Trials (17)

Total enrollment: 65,051 patients across 17 trials

NCT06736665AbbottPercutaneous coronary intervention

Orbital Atherectomy vs Intravascular Lithotripsy for the Treatment of Calcified Coronary Nodules (ORBIT-SHOCK).

Start: Mar 2025Est. completion: Dec 202650 patients
Phase 4Not Yet Recruiting
NCT01489761AbbottPercutaneous coronary intervention

LONG-DES VI (Drug Eluting Stent for Long Lesions in Coronary Artery)

Start: Jan 2012Est. completion: Feb 2017302 patients
Phase 4Terminated
NCT00987610AbbottPercutaneous coronary intervention

Guidewire for Chronic Total Occlusion

Start: Oct 2009Est. completion: Dec 2014260 patients
Phase 4Completed
NCT01056744AbbottPercutaneous coronary intervention

Optical Coherence Tomography to Evaluate Paclitaxel-Eluting Balloons and Everolimus-Eluting Coronary Stents

Start: Jun 2009Est. completion: Jun 201290 patients
Phase 4Completed
NCT05848232Reflow MedicalcoraFlex Catheter

Single-Arm Study Evaluating Use of the CORA Catheters for the Crossing of Coronary Chronic Total Occlusions

Start: Jun 2024Est. completion: Feb 2025150 patients
Phase 3Unknown
NCT07114393AbbottPercutaneous coronary intervention

Optimization of Complex Percutaneous Coronary Intervention With Liberal Use of Intracoronary Imaging Versus Contemporary Practice

Start: Apr 2025Est. completion: May 202711,092 patients
N/ARecruiting
NCT04475380AbbottPercutaneous coronary intervention

Complex All-comers and Patients With Diabetes or Prediabetes, Treated With Xience Sierra Everolimus-eluting Stents

Start: Sep 2018Est. completion: Dec 20251,757 patients
N/ACompleted
NCT03507777AbbottPercutaneous coronary intervention

ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI)

Start: May 2018Est. completion: Feb 20232,487 patients
N/ACompleted
NCT03667196AbbottPercutaneous coronary intervention

Evaluation of Effectiveness and Safety of Antegrade and Retrograde Approach of Percutaneous Coronary Intervention for Chronic Total Occlusions

Start: Jan 2018Est. completion: Dec 20274,000 patients
N/ARecruiting
NCT01986803AbbottPercutaneous coronary intervention

ABSORB STEMI: the TROFI II Study

Start: Jan 2014Est. completion: Sep 2017191 patients
N/ACompleted
NCT01930214AbbottPercutaneous coronary intervention

Multi-center Prospective Study to Evaluate Outcomes of the Moderate to Severely Calcified Coronary Lesions (MACE)

Start: Sep 2013Est. completion: Jun 2017350 patients
N/ACompleted
NCT01366404AbbottPercutaneous coronary intervention

Study of the Natural History of FFR Guided Percutaneous Coronary Intervention

Start: Jun 2011Est. completion: Apr 203720,000 patients
N/ARecruiting
NCT01205776AbbottPercutaneous coronary intervention

EXCEL Clinical Trial

Start: Sep 2010Est. completion: Jun 20191,905 patients
N/ACompleted
NCT02198716AbbottPercutaneous coronary intervention

Xience or Vision Stent Management of Angina in the Elderly

Start: Nov 2008Est. completion: Aug 2012800 patients
N/ACompleted
NCT00842179AbbottPercutaneous coronary intervention

Groin Complications Post Percutaneous Coronary Intervention Using Either Manual Compression or PERCLOSE Device

Start: Jun 2008Est. completion: Oct 20082,517 patients
N/ACompleted
NCT06089304AbbottPercutaneous coronary intervention

Patient Centered Machine Learning Model for Bleeding and Ischemic Risk

Start: May 2008Est. completion: Oct 202319,000 patients
N/ACompleted
NCT00419055AbbottPercutaneous coronary intervention

Outpatient Percutaneous Coronary Intervention

Start: Aug 2004Est. completion: Aug 2006100 patients
N/ATerminated

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
3 actively recruiting trials targeting 65,051 patients
2 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)