Coronary Disease

Cardiovascular
9
Pipeline Programs
10
Companies
25
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
4
1
2
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Abbott
AbbottABBOTT PARK, IL
9 programs
1
1
1
TAXUS® Liberté™Phase 41 trial
ZoMaxx™ Drug-Eluting Coronary Stent SystemPhase 2/31 trial
ZoMaxx™ Drug-Eluting Coronary Stent SystemPhase 21 trial
Absorb BVSN/A1 trial
Bioabsorbable Everolimus Eluting Coronary StentN/A1 trial
+4 more programs
Active Trials
NCT01977534Completed1,005Est. Oct 2018
NCT00300131Completed30Est. Jul 2011
NCT00856856Completed101Est. Mar 2016
+6 more trials
C
CordisFL - Miami Lakes
4 programs
1
2
CoStar Paclitaxel Drug Eluting Coronary Stent SystemPhase 31 trial
Corio™ Pimecrolimus-Eluting Coronary Stent SystemPhase 31 trial
NEVO™ Sirolimus-eluting Coronary Stent SystemPhase 21 trial
Exoseal closure deviceN/A
Active Trials
NCT00714883Terminated3Est. Oct 2012
NCT00165035Completed1,701Est. Jul 2011
NCT00322569Completed246Est. May 2012
M&
Merck & Co.RAHWAY, NJ
1 program
1
INS50589 Intravenous InfusionPhase 22 trials
Active Trials
NCT00316212Terminated160
NCT00099450Completed48Est. Mar 2005
Sanofi
SanofiPARIS, France
1 program
1
OtamixabanPhase 25 trials
Active Trials
NCT01126086Completed25Est. Apr 2011
NCT01120314Completed48Est. Jul 2011
NCT01076764Completed13,220Est. May 2013
+2 more trials
Precision BioSciences
1 program
1
RUC-4 CompoundPhase 11 trial
Active Trials
NCT03844191Completed44Est. Dec 2019
Elutia
ElutiaSILVER SPRING, MD
2 programs
CorMatrix CanGaroo ECM EnvelopeN/A1 trial
Obtain Additional Information on Use of CorMatrix ECM (Extracellular Matrix)N/A1 trial
Active Trials
NCT02418143WithdrawnEst. Feb 2016
NCT02073331CompletedEst. Dec 2017
DS
Daiichi SankyoChina - Shanghai
1 program
OCTN/A1 trial
Active Trials
NCT03176810Unknown550Est. Jun 2021
Biotronik
BiotronikGermany - Berlin
1 program
Percutaneous Coronary InterventionN/A1 trial
Active Trials
NCT05529459Recruiting2,400Est. Jul 2030
Robocath
RobocathFrance - Rouen
1 program
Robotic-assisted PCIN/A1 trial
Active Trials
NCT05853419Recruiting500Est. Jun 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
AbbottTAXUS® Liberté™
SanofiOtamixaban
CordisCorio™ Pimecrolimus-Eluting Coronary Stent System
CordisCoStar Paclitaxel Drug Eluting Coronary Stent System
AbbottZoMaxx™ Drug-Eluting Coronary Stent System
CordisNEVO™ Sirolimus-eluting Coronary Stent System
SanofiOtamixaban
Merck & Co.INS50589 Intravenous Infusion
AbbottZoMaxx™ Drug-Eluting Coronary Stent System
SanofiOtamixaban
Precision BioSciencesRUC-4 Compound
SanofiOtamixaban
SanofiOtamixaban
Merck & Co.INS50589 Intravenous Infusion
RobocathRobotic-assisted PCI

Showing 15 of 25 trials with date data

Clinical Trials (25)

Total enrollment: 28,611 patients across 25 trials

NCT01171820AbbottTAXUS® Liberté™

SPIRIT V: A Clinical Evaluation of the XIENCE V® Everolimus Eluting Coronary Stent System in the Treatment of Patients With de Novo Coronary Artery Lesions (Diabetic Sub-Study)

Start: Nov 2006Est. completion: Jul 2010324 patients
Phase 4Completed

Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy

Start: Apr 2010Est. completion: May 201313,220 patients
Phase 3Completed
NCT00322569CordisCorio™ Pimecrolimus-Eluting Coronary Stent System

A Randomized, Multi-Center Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent Systems (GENESIS)

Start: Jul 2006Est. completion: May 2012246 patients
Phase 3Completed
NCT00165035CordisCoStar Paclitaxel Drug Eluting Coronary Stent System

Cobalt Chromium Stent With Antiproliferative for Restenosis II Trial (COSTAR II)

Start: May 2005Est. completion: Jul 20111,701 patients
Phase 3Completed
NCT00148356AbbottZoMaxx™ Drug-Eluting Coronary Stent System

Safety and Efficacy of the ZoMaxx™ Drug-Eluting Stent System in Coronary Arteries

Start: Sep 2004Est. completion: Oct 2010401 patients
Phase 2/3Completed
NCT00714883CordisNEVO™ Sirolimus-eluting Coronary Stent System

Conor Cobalt Chromium Reservoir Based Stent With Sirolimus Elution in Native Coronary Artery Lesions

Start: Jun 2008Est. completion: Oct 20123 patients
Phase 2Terminated

Study of Otamixaban Versus Unfractionated Heparin (UFH) and Eptifibatide in Non-ST Elevation Acute Coronary Syndrome

Start: Jun 2006Est. completion: Mar 20093,241 patients
Phase 2Completed
NCT00316212Merck & Co.INS50589 Intravenous Infusion

Study of INS50589 Intravenous Infusion in Subjects Undergoing Coronary Artery Bypass Grafting (CABG) Involving Cardiopulmonary Bypass

Start: Apr 2006160 patients
Phase 2Terminated
NCT00140101AbbottZoMaxx™ Drug-Eluting Coronary Stent System

Safety and Efficacy of the ZoMaxx™ Drug-Eluting Stent System in Coronary Arteries

Start: May 2005Est. completion: Jan 20121,099 patients
Phase 2Completed

The SEPIA-PCI Trial: Otamixaban in Comparison to Heparin in Subjects Undergoing Non-Urgent Percutaneous Coronary Intervention

Start: Sep 2004Est. completion: Oct 2005947 patients
Phase 2Completed

A Randomized Phase 1 Dose-Escalation Study of Subcutaneously(SC) Administered RUC-4

Start: Feb 2019Est. completion: Dec 201944 patients
Phase 1Completed

Pharmacokinetic, Pharmacodynamic and Tolerability Study of Otamixaban in Patients With Mild and Moderate Hepatic Impairment

Start: May 2010Est. completion: Apr 201125 patients
Phase 1Completed

Pharmacokinetic, Pharmacodynamic and Tolerability Study of Otamixaban in Patients With Mild, Moderate and Severe Renal Impairment

Start: Apr 2010Est. completion: Jul 201148 patients
Phase 1Completed
NCT00099450Merck & Co.INS50589 Intravenous Infusion

Study of the Tolerability, Pharmacokinetics, and Pharmacodynamics of INS50589 Intravenous Infusion in Healthy Volunteers

Start: Dec 2004Est. completion: Mar 200548 patients
Phase 1Completed
NCT05853419RobocathRobotic-assisted PCI

Change History and Adopt a Robotic SolutioN for anGioplasty procedurE

Start: Jun 2023Est. completion: Jun 2026500 patients
N/ARecruiting
NCT05529459BiotronikPercutaneous Coronary Intervention

Anatomic Versus Physiologic Guidance for Complete Revascularization With DES Eluting in Patients With CAD

Start: Mar 2023Est. completion: Jul 20302,400 patients
N/ARecruiting

Comparison Between Optimal Coherence Tomography Guidance and Angiography Guidance in Percutaneous Coronary Intervention

Start: Apr 2017Est. completion: Jun 2021550 patients
N/AUnknown
NCT02418143ElutiaCorMatrix CanGaroo ECM Envelope

A Study to Obtain Additional Information on the Use of CorMatrix® CanGaroo ECM® Envelope

Start: Sep 2015Est. completion: Feb 2016
N/AWithdrawn
NCT02073331ElutiaObtain Additional Information on Use of CorMatrix ECM (Extracellular Matrix)

Obtain Additional Information on Use of CorMatrix ECM (Extracellular Matrix)

Start: Mar 2014Est. completion: Dec 2017
N/ACompleted

To Study the Safety and Clinical Outcomes of the Absorb Bioresorbable Vascular Scaffold (BVS) System in Patients With de Novo Lesions in Previously Untreated Vessels

Start: Jan 2014Est. completion: Oct 20181,005 patients
N/ACompleted
NCT02234830AbbottExoseal closure device

Randomized Comparison of ExoSeal® and Angio-Seal Vascular Closure Devices: The CLOSE-UP II Trial

Start: Dec 2012Est. completion: May 2017818 patients
N/ACompleted
NCT00856856AbbottBioabsorbable Everolimus Eluting Coronary Stent

ABSORB Clinical Investigation, Cohort B

Start: Mar 2009Est. completion: Mar 2016101 patients
N/ACompleted
NCT01310309AbbottCoronary artery placement of a drug-eluting stent

EXecutive Registry: Evaluating XIENCE V® in a Multi Vessel Disease

Start: Sep 2007Est. completion: Jun 2011400 patients
N/ACompleted
NCT00300131AbbottBioabsorbable Everolimus Eluting Coronary Stent

ABSORB Clinical Investigation, Cohort A (ABSORB A) Everolimus Eluting Coronary Stent System Clinical Investigation

Start: Mar 2006Est. completion: Jul 201130 patients
N/ACompleted
NCT00243438AbbottMultilink Vision™ Stent

DaVinci Registry(Distinctly Assess Vision in Coronary Intervention)

Start: Jul 2003Est. completion: Mar 20051,300 patients
N/ACompleted

Related Jobs in Cardiovascular

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 28,611 patients
10 companies competing in this space