Coronary Artery Disease (CAD)

Cardiovascular
5
Pipeline Programs
6
Companies
5
Clinical Trials
1 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
1
2
Early DiscoveryClinical DevelopmentMarket

On Market (2)

Approved therapies currently available

Astellas
LEXISCANApproved
regadenoson
Astellas
Adenosine Receptor Agonist [EPC]intravenous2008
U
REGADENOSONApproved
regadenoson
Unknown Company
Adenosine Receptor Agonist [EPC]intravenous2024

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Astellas
AstellasChina - Shenyang
1 program
1
1
RegadenosonPhase 31 trial
Active Trials
NCT01618669Completed1,147Est. Dec 2014
DS
Daiichi SankyoChina - Shanghai
1 program
1
PrasugrelPhase 21 trial
Active Trials
NCT00910299Terminated423Est. Apr 2011
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD5718 tablet, Formulation APhase 11 trial
Active Trials
NCT04210388Completed12Est. Mar 2020
Lantheus Medical Imaging
1 program
BMS747158N/A1 trial
Active Trials
NCT01085162WithdrawnEst. Mar 2015
HeartFlow
HeartFlowMOUNTAIN VIEW, CA
1 program
Coronary computed tomography angiographyN/A1 trial
Active Trials
NCT06831409Recruiting300Est. Dec 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AstellasRegadenoson
Daiichi SankyoPrasugrel
AstraZenecaAZD5718 tablet, Formulation A
HeartFlowCoronary computed tomography angiography
Lantheus Medical ImagingBMS747158

Clinical Trials (5)

Total enrollment: 1,882 patients across 5 trials

NCT01618669AstellasRegadenoson

A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT)

Start: Jun 2012Est. completion: Dec 20141,147 patients
Phase 3Completed
NCT00910299Daiichi SankyoPrasugrel

Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy With Prasugrel (TRIGGER-PCI)

Start: Jul 2009Est. completion: Apr 2011423 patients
Phase 2Terminated
NCT04210388AstraZenecaAZD5718 tablet, Formulation A

A Study to Assess the Amount of Drug Levels in Blood and Safety of AZD5718 Formulations in Healthy Volunteers

Start: Jan 2020Est. completion: Mar 202012 patients
Phase 1Completed
NCT06831409HeartFlowCoronary computed tomography angiography

Using CTA Measures to Define Cardiac Risk In NFL Alumni

Start: Dec 2024Est. completion: Dec 2026300 patients
N/ARecruiting
NCT01085162Lantheus Medical ImagingBMS747158

A Long-term Follow-up Study to Evaluate the Predictive Value of BMS747158 in Patients Suspected of Coronary Artery Disease (CAD)

Start: Mar 2013Est. completion: Mar 2015
N/AWithdrawn

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 1,882 patients
6 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)