Colorectal Adenocarcinoma

Oncology
9
Pipeline Programs
10
Companies
8
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
3
4
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
267%
Monoclonal Antibody
133%
+ 7 programs with unclassified modality

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Alliance Pharmaceuticals
1 program
1
BevacizumabPhase 3Monoclonal Antibody1 trial
Active Trials
NCT04094688Active Not Recruiting455Est. Jul 2026
Bristol Myers Squibb
1 program
1
CabozantinibPhase 2Small Molecule1 trial
Active Trials
NCT04963283Active Not Recruiting48Est. Feb 2026
Achieve Life Sciences
1 program
1
S-8184 Paclitaxel Injectable EmulsionPhase 21 trial
Active Trials
NCT00034190CompletedEst. Sep 2007
Novartis
NovartisBASEL, Switzerland
1 program
1
ceritinibPhase 2Small Molecule1 trial
Active Trials
NCT02638909Terminated4Est. Mar 2018
Pfizer
PfizerNEW YORK, NY
1 program
1
perioperative chemotherapyPhase 21 trial
Active Trials
NCT00168155Completed70Est. May 2009
Astex Pharmaceuticals
Astex PharmaceuticalsUK - Cambridge
1 program
1
GuadecitabinePhase 1/2
Taiho Oncology
Taiho OncologyNJ - Princeton
1 program
1
Nanoliposomal IrinotecanPhase 1/2
Ipsen
IpsenChina - Tianjin
1 program
1
Nanoliposomal IrinotecanPhase 1/21 trial
Active Trials
NCT03368963Active Not Recruiting64Est. Nov 2025
M&
Merck & Co.RAHWAY, NJ
1 program
1
XL888Phase 11 trial
Active Trials
NCT03095781Completed49Est. Jun 2021
Genomics
GenomicsUK - Oxford
1 program
Blood drawN/A1 trial
Active Trials
NCT03706235Completed488Est. Apr 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Alliance PharmaceuticalsBevacizumab
Bristol Myers SquibbCabozantinib
Novartisceritinib
Achieve Life SciencesS-8184 Paclitaxel Injectable Emulsion
Pfizerperioperative chemotherapy
IpsenNanoliposomal Irinotecan
Merck & Co.XL888
GenomicsBlood draw

Clinical Trials (8)

Total enrollment: 1,178 patients across 8 trials

NCT04094688Alliance PharmaceuticalsBevacizumab

Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

Start: Oct 2019Est. completion: Jul 2026455 patients
Phase 3Active Not Recruiting
NCT04963283Bristol Myers SquibbCabozantinib

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

Start: Jun 2021Est. completion: Feb 202648 patients
Phase 2Active Not Recruiting
NCT02638909Novartisceritinib

Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal Malignancies

Start: Dec 2015Est. completion: Mar 20184 patients
Phase 2Terminated
NCT00034190Achieve Life SciencesS-8184 Paclitaxel Injectable Emulsion

Safety and Efficacy of S-8184 in Second Line Treatment of Stage III or IV Colorectal Adenocarcinoma

Start: Mar 2002Est. completion: Sep 2007
Phase 2Completed
NCT00168155Pfizerperioperative chemotherapy

Study of 5-FU + Leucovorin + CPT-11 in Patients With Resectable Liver Metastases From Colorectal Adenocarcinoma

Start: Jan 2002Est. completion: May 200970 patients
Phase 2Completed
NCT03368963IpsenNanoliposomal Irinotecan

TAS102 in Combination With NAL-IRI in Advanced GI Cancers

Start: Jan 2018Est. completion: Nov 202564 patients
Phase 1/2Active Not Recruiting
NCT03095781Merck & Co.XL888

Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancer

Start: Jul 2017Est. completion: Jun 202149 patients
Phase 1Completed
NCT03706235GenomicsBlood draw

Colvera for Detection of Disease Recurrence

Start: Feb 2018Est. completion: Apr 2020488 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
10 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)