C3 Glomerulopathy
Nephrology
3
Pipeline Programs
3
Companies
5
Clinical Trials
2 recruiting
0
Approved Products
Pipeline by Development Stage
Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
2
0
0
1
0
Early DiscoveryClinical DevelopmentMarket
Competitive Landscape
3 companies ranked by most advanced pipeline stage
NovartisBASEL, Switzerland
3 programs1
LNP023Phase 31 trial
Home Reported Outcomes in C3G StudyN/A1 trial
IptacopanN/A1 trial
Active Trials
Trial Timeline
Clinical trial activity over time
2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
NovartisLNP023
NovelMed TherapeuticsNM8074
Arrowhead PharmaceuticalsARO-C3
NovartisIptacopan
NovartisHome Reported Outcomes in C3G Study
Clinical Trials (5)
Total enrollment: 470 patients across 5 trials
Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
Start: Oct 2019Est. completion: May 2036225 patients
Phase 3Recruiting
Study of NM8074 in Adult C3 Glomerulopathy Patients
Start: Nov 2025Est. completion: Jul 2027
Phase 1/2Not Yet Recruiting
Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease
Start: Feb 2022Est. completion: Oct 202562 patients
Phase 1/2Completed
CHART-C3G/CLNP023B12011
Start: Jan 2026Est. completion: Mar 202783 patients
N/ANot Yet Recruiting
Home Reported Outcomes in C3G Study
Start: Apr 2025Est. completion: Apr 2026100 patients
N/ARecruiting
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Phase Legend
Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available
Key Insights
1 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 470 patients
3 companies competing in this space