Aortic Stenosis

Cardiovascular
0
Pipeline Programs
3
Companies
4
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Rhythm Pharmaceuticals
2 programs
CoreValve aortic valveN/A1 trial
TAVR Procedure and implantation of Boston Scientific Loop RecorderN/A1 trial
Active Trials
NCT01676727Completed100Est. Aug 2015
NCT06055751Recruiting50Est. Dec 2025
Abbott
AbbottABBOTT PARK, IL
1 program
Navitor Transcatheter Aortic Valve, FlexNav Delivery System, Navitor Loading SystemN/A1 trial
Active Trials
NCT06008080Recruiting1,000Est. Dec 2031
JenaValve
JenaValveCA - Irvine
1 program
Transcatheter aortic valve replacementN/A1 trial
Active Trials
NCT01598844CompletedEst. Jul 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
AbbottNavitor Transcatheter Aortic Valve, FlexNav Delivery System, Navitor Loading System
Rhythm PharmaceuticalsTAVR Procedure and implantation of Boston Scientific Loop Recorder
Rhythm PharmaceuticalsCoreValve aortic valve
JenaValveTranscatheter aortic valve replacement

Clinical Trials (4)

Total enrollment: 1,150 patients across 4 trials

NCT06008080AbbottNavitor Transcatheter Aortic Valve, FlexNav Delivery System, Navitor Loading System

Post-Market Clinical Follow Up Study With Navitor Valve

Start: Sep 2023Est. completion: Dec 20311,000 patients
N/ARecruiting
NCT06055751Rhythm PharmaceuticalsTAVR Procedure and implantation of Boston Scientific Loop Recorder

Long Term Evaluation of Cardiac Arrhythmias After Transcatheter Aortic Valve Implantation -The LOCATE Registry

Start: Sep 2023Est. completion: Dec 202550 patients
N/ARecruiting
NCT01676727Rhythm PharmaceuticalsCoreValve aortic valve

ADVANCE Direct Aortic Study

Start: Sep 2012Est. completion: Aug 2015100 patients
N/ACompleted
NCT01598844JenaValveTranscatheter aortic valve replacement

JUPITER Study: Transapical Aortic Valve Implantation for Aortic Regurgitation

Start: May 2012Est. completion: Jul 2018
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 1,150 patients
3 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)