Advanced Soft Tissue Sarcoma
Oncology
3
Pipeline Programs
4
Companies
3
Clinical Trials
0
Approved Products
Pipeline by Development Stage
Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
1
0
Early DiscoveryClinical DevelopmentMarket
Competitive Landscape
3 companies ranked by most advanced pipeline stage
AstraZenecaCAMBRIDGE, United Kingdom
1 program1
Standard arm: Trabectedin in monotherapyPhase 21 trial
Active Trials
Trial Timeline
Clinical trial activity over time
2021
2022
2023
2024
2025
2026
2027
2028
Boehringer IngelheimBrigimadlin
AstraZenecaStandard arm: Trabectedin in monotherapy
Knight TherapeuticsDoxorubicin Hydrochloride
Clinical Trials (3)
Total enrollment: 146 patients across 3 trials
Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma
Start: Jun 2024Est. completion: Oct 20280
Phase 3Withdrawn
Randomized Trial in Advanced, Metastatic or Unresectable Soft Tissue Sarcoma After Failure of Standard Treatments.
Start: May 2020Est. completion: Nov 2024130 patients
Phase 2Completed
Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery
Start: Mar 2017Est. completion: Jun 202316 patients
Phase 1Completed
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Phase Legend
Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available
Key Insights
1 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space