Advanced Prostate Cancer

Oncology
6
Pipeline Programs
9
Companies
8
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
2
1
0
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
Zoladex and CasodexPhase 41 trial
Active Trials
NCT03971110Terminated9Est. Nov 2022
Ipsen
IpsenChina - Tianjin
1 program
1
Triptorelin pamoatePhase 31 trial
Active Trials
NCT05590793Completed195Est. Aug 2024
Novartis
NovartisBASEL, Switzerland
1 program
1
BKM 120Phase 21 trial
Active Trials
NCT02035124Withdrawn0Est. Jan 2015
M&
Merck & Co.RAHWAY, NJ
1 program
1
HPN424 Fixed IV 1.3 to 150 ng/kgPhase 1/21 trial
Active Trials
NCT03577028Terminated104Est. Feb 2023
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
1 program
1
QLC5508Phase 1/21 trial
Active Trials
NCT07198633Not Yet RecruitingEst. Dec 2027
Genentech
GenentechCA - Oceanside
1 program
1
RO7656594Phase 11 trial
Active Trials
NCT05800665Recruiting210Est. Jun 2027
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
1 program
DegarelixN/A1 trial
Active Trials
NCT02234089Completed461Est. Jun 2019
Abbott
AbbottABBOTT PARK, IL
1 program
Leuprolide acetate Depot Susp. 11.25 mgN/A1 trial
Active Trials
NCT01078545Completed729Est. Nov 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
AstraZenecaZoladex and Casodex
IpsenTriptorelin pamoate
NovartisBKM 120
Qilu PharmaceuticalQLC5508
Merck & Co.HPN424 Fixed IV 1.3 to 150 ng/kg
GenentechRO7656594
Ferring PharmaceuticalsDegarelix
AbbottLeuprolide acetate Depot Susp. 11.25 mg

Clinical Trials (8)

Total enrollment: 1,708 patients across 8 trials

NCT03971110AstraZenecaZoladex and Casodex

A Study of Neoadjuvant Hormone Therapy in Patient With Advanced Prostate Cancer Undergoing Radical Prostatectomy.

Start: Jan 2021Est. completion: Nov 20229 patients
Phase 4Terminated
NCT05590793IpsenTriptorelin pamoate

Effects of Triptorelin Pamoate 6-month When Given to Adult Chinese Participants With Advanced Cancer in the Prostate

Start: Nov 2022Est. completion: Aug 2024195 patients
Phase 3Completed
NCT02035124NovartisBKM 120

Cabazitaxel and BKM120 in Patients With Metastatic Castrate-Resistant Prostate Cancer (mCRPC) Previously Treated With Docetaxel

Start: Apr 2014Est. completion: Jan 20150
Phase 2Withdrawn
NCT07198633Qilu PharmaceuticalQLC5508

A Clinical Study of QLC5508 and/or QLH12016 in Combination With Other Anti-tumor Therapies in Subjects With Advanced Prostate Cancer

Start: Oct 2025Est. completion: Dec 2027
Phase 1/2Not Yet Recruiting
NCT03577028Merck & Co.HPN424 Fixed IV 1.3 to 150 ng/kg

Study of HPN424 in Patients With Advanced Prostate Cancer

Start: Jul 2018Est. completion: Feb 2023104 patients
Phase 1/2Terminated
NCT05800665GenentechRO7656594

A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

Start: May 2023Est. completion: Jun 2027210 patients
Phase 1Recruiting
NCT02234089Ferring PharmaceuticalsDegarelix

Therapy Pathways in the Treatment of Hormone Naïve Prostate Cancer Patients With and Without Comorbidities Treated With Degarelix or Luteinizing-Hormone-Releasing-Hormone (LHRH) Agonists.

Start: Sep 2014Est. completion: Jun 2019461 patients
N/ACompleted
NCT01078545AbbottLeuprolide acetate Depot Susp. 11.25 mg

Lucrin® Depot Efficacy and Safety Monitoring Study in Patients With Advanced Prostate Cancer and Lower Urinary Tract Symptoms (LUTS)

Start: Sep 2008Est. completion: Nov 2010729 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 1,708 patients
9 companies competing in this space

Related Indications

Breast Cancer(577)Prostate Cancer(385)Non-small Cell Lung Cancer(378)Multiple Myeloma(359)Cancer(249)Advanced Solid Tumors(226)Acute Myeloid Leukemia(209)Neoplasms(199)Colorectal Cancer(171)Melanoma(170)