Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

Oncology
3
Pipeline Programs
2
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
0
0
2
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

2 companies ranked by most advanced pipeline stage

PB
Puhe BiopharmaChina - Suzhou
2 programs
1
1
YK-209A tabletPhase 31 trial
PH009-1 tabletPhase 1/21 trial
Active Trials
NCT06590194Not Yet RecruitingEst. Aug 2026
NCT05767892Not Yet RecruitingEst. Dec 2026
Takeda
TakedaTOKYO, Japan
1 program
1
TAK-788Phase 35 trials
Active Trials
NCT04441255Completed14Est. Aug 2020
NCT04129502Active Not Recruiting354Est. Oct 2026
NCT03928327Completed24Est. Aug 2019
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Puhe BiopharmaYK-209A tablet
TakedaTAK-788
Puhe BiopharmaPH009-1 tablet
TakedaTAK-788
TakedaTAK-788
TakedaTAK-788
TakedaTAK-788

Clinical Trials (7)

Total enrollment: 733 patients across 7 trials

YK-029A as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations

Start: May 2023Est. completion: Dec 2026
Phase 3Not Yet Recruiting

TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations

Start: Jan 2020Est. completion: Oct 2026354 patients
Phase 3Active Not Recruiting

PH009-1 in Patients With EGFR Mutation Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)

Start: Sep 2024Est. completion: Aug 2026
Phase 1/2Not Yet Recruiting

A Study of TAK-788 in Adults With Non-Small Cell Lung Cancer

Start: Jun 2016Est. completion: Oct 2026334 patients
Phase 1/2Active Not Recruiting

A Study to Evaluate the Effect of High-Fat Meal on TAK-788 Pharmacokinetics (PK) in Healthy Adult Participants

Start: Jul 2020Est. completion: Aug 202014 patients
Phase 1Completed

A Study to Evaluate Drug-Drug Interaction of TAK-788 With Itraconazole and Rifampin in Healthy Adult Participants

Start: May 2019Est. completion: Aug 201924 patients
Phase 1Completed

A Study to Assess Absolute Bioavailability (ABA) of Mobocertinib (TAK-788) and to Characterize Mass Balance, Pharmacokinetics (PK), Metabolism, and Excretion of Carbon-14 ([14C])-Mobocertinib in Male Healthy Participants

Start: Jan 2019Est. completion: Mar 20197 patients
Phase 1Completed

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
2 companies competing in this space