Advanced Malignant Solid Tumors

Oncology
4
Pipeline Programs
3
Companies
4
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

H
HutchmedChina - Hong Kong
2 programs
2
HMPL-415S1Phase 11 trial
HMPL-653Phase 11 trial
Active Trials
NCT05886374Recruiting81Est. Jun 2026
NCT05277454Unknown113Est. Apr 2025
Takeda
TakedaTOKYO, Japan
1 program
1
MLN7243Phase 11 trial
Active Trials
NCT02045095Terminated29Est. Nov 2016
Pfizer
PfizerNEW YORK, NY
1 program
1
PKI-179Phase 11 trial
Active Trials
NCT00997360Withdrawn0Est. Feb 2012

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
HutchmedHMPL-415S1
HutchmedHMPL-653
TakedaMLN7243
PfizerPKI-179

Clinical Trials (4)

Total enrollment: 223 patients across 4 trials

NCT05886374HutchmedHMPL-415S1

A Study of HMPL-415S1 in Patients With Advanced Malignant Solid Tumors

Start: Jul 2023Est. completion: Jun 202681 patients
Phase 1Recruiting
NCT05277454HutchmedHMPL-653

Clinical Study of HMPL-653 in Treatment of Advanced Malignant Solid Tumors and TGCT

Start: Jan 2022Est. completion: Apr 2025113 patients
Phase 1Unknown
NCT02045095TakedaMLN7243

A Dose Escalation Study of MLN7243 (TAK-243) in Adult Participants With Advanced Solid Tumors

Start: Jan 2014Est. completion: Nov 201629 patients
Phase 1Terminated
NCT00997360PfizerPKI-179

Study of PKI-179 Administered Orally to Subjects With Solid Tumors

Start: Feb 2010Est. completion: Feb 20120
Phase 1Withdrawn

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 223 patients
3 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)