Advanced Colorectal Cancer

Oncology
6
Pipeline Programs
6
Companies
6
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
4
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
2100%
+ 4 programs with unclassified modality

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Abbott
AbbottABBOTT PARK, IL
1 program
1
ABT-869Phase 21 trial
Active Trials
NCT00707889Completed159Est. May 2012
DS
Daiichi SankyoChina - Shanghai
1 program
1
DS-8201a 5.4 mg/kg Q3WPhase 21 trial
Active Trials
NCT04744831Completed122Est. Dec 2024
E
EisaiChina - Liaoning
1 program
1
E7820 plus cetuximabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT00309179Completed41Est. Feb 2017
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
PanitumumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT03311750Terminated23Est. May 2021
CT
1 program
1
AL2846Phase 1/21 trial
Active Trials
NCT04337879UnknownEst. Dec 2020
AT
1 program
1
Paclitaxel PoliglumexPhase 11 trial
Active Trials
NCT00598247CompletedEst. Jul 2011

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Daiichi SankyoDS-8201a 5.4 mg/kg Q3W
AmgenPanitumumab
AbbottABT-869
EisaiE7820 plus cetuximab
Chia Tai TianQing Pharmaceutical GroupAL2846
Ascend TherapeuticsPaclitaxel Poliglumex

Clinical Trials (6)

Total enrollment: 345 patients across 6 trials

NCT04744831Daiichi SankyoDS-8201a 5.4 mg/kg Q3W

Trastuzumab Deruxtecan in Participants With HER2-overexpressing Advanced or Metastatic Colorectal Cancer

Start: Mar 2021Est. completion: Dec 2024122 patients
Phase 2Completed
NCT03311750AmgenPanitumumab

Anti-EGFR Therapy Rechallenge in Combination With Chemotherapy in Patients With Advanced Colorectal Cancer

Start: Mar 2018Est. completion: May 202123 patients
Phase 2Terminated
NCT00707889AbbottABT-869

Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer

Start: Oct 2008Est. completion: May 2012159 patients
Phase 2Completed
NCT00309179EisaiE7820 plus cetuximab

A Phase II Study of the Safety and Efficacy of E7820 Plus Cetuximab in Colorectal Cancer, Preceded by a Run-in Study in Advanced Solid Tumors

Start: Sep 2007Est. completion: Feb 201741 patients
Phase 2Completed
NCT04337879Chia Tai TianQing Pharmaceutical GroupAL2846

A Study of AL2846 Capsule Combined With Standard Chemotherapy Regimen in Subjects With Advanced Colorectal Cancer

Start: Jul 2020Est. completion: Dec 2020
Phase 1/2Unknown
NCT00598247Ascend TherapeuticsPaclitaxel Poliglumex

A Pilot Study of PPX in Women With Metastatic Colorectal Cancer

Start: Jan 2008Est. completion: Jul 2011
Phase 1Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

6 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)