Adenocarcinoma of the Prostate

Oncology
11
Pipeline Programs
9
Companies
9
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
6
0
2
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
150%
Monoclonal Antibody
150%
+ 8 programs with unclassified modality

On Market (1)

Approved therapies currently available

Astellas
XTANDIApproved
enzalutamide
Astellas
Androgen Receptor Inhibitor [EPC]oral2012

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Astellas
AstellasChina - Shenyang
1 program
1
1
EnzalutamidePhase 21 trial
Active Trials
NCT02203695Completed86Est. Dec 2022
Sanofi
SanofiPARIS, France
1 program
1
Active CTC AssessmentPhase 3
Alliance Pharmaceuticals
1 program
1
enzalutamidePhase 31 trial
Active Trials
NCT01949337Unknown1,311Est. Aug 2024
Knight Therapeutics
Knight TherapeuticsQC - Montréal
4 programs
1
3
CelecoxibPhase 2Small Molecule1 trial
SulforaphanePhase 21 trial
ipilimumabPhase 2Monoclonal Antibody1 trial
abiraterone acetatePhase 11 trial
Active Trials
NCT01913015Terminated3
NCT02840162Terminated34Est. May 2011
NCT01228084Completed20Est. May 2013
+1 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
IMC-A12Phase 21 trial
Active Trials
NCT00520481Completed41Est. Aug 2013
Biotest Pharmaceuticals
Biotest PharmaceuticalsGermany - Dreieich
1 program
1
NanoPac®Phase 21 trial
Active Trials
NCT03077659CompletedEst. Oct 2018
Providence Therapeutics
1 program
1
CyclophosphamidePhase 11 trial
Active Trials
NCT02234921CompletedEst. Aug 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Alliance Pharmaceuticalsenzalutamide
Biotest PharmaceuticalsNanoPac®
AstellasEnzalutamide
Knight Therapeuticsipilimumab
Knight TherapeuticsSulforaphane
Eli Lilly and CompanyIMC-A12
Knight TherapeuticsCelecoxib
Providence TherapeuticsCyclophosphamide
Knight Therapeuticsabiraterone acetate

Clinical Trials (9)

Total enrollment: 1,505 patients across 9 trials

NCT01949337Alliance Pharmaceuticalsenzalutamide

Enzalutamide With or Without Abiraterone and Prednisone in Treating Patients With Castration-Resistant Metastatic Prostate Cancer

Start: Jan 2014Est. completion: Aug 20241,311 patients
Phase 3Unknown
NCT03077659Biotest PharmaceuticalsNanoPac®

Trial of NanoPac® Focal Therapy in Subjects With Prostate Cancer

Start: Sep 2017Est. completion: Oct 2018
Phase 2Completed
NCT02203695AstellasEnzalutamide

Randomized Salvage Radiation Therapy Plus Enzalutamide Post Prostatectomy

Start: Mar 2015Est. completion: Dec 202286 patients
Phase 2Completed
NCT01498978Knight Therapeuticsipilimumab

Ipilimumab in Combination With Androgen Suppression Therapy in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer

Start: Feb 2012Est. completion: Jan 201910 patients
Phase 2Completed
NCT01228084Knight TherapeuticsSulforaphane

Sulforaphane in Treating Patients With Recurrent Prostate Cancer

Start: Nov 2010Est. completion: May 201320 patients
Phase 2Completed
NCT00520481Eli Lilly and CompanyIMC-A12

Study With IMC-A12 (Cixutumumab) in Patients Who Have Not Previously Been Treated With Chemotherapy With Metastatic Prostate Cancer

Start: Aug 2007Est. completion: Aug 201341 patients
Phase 2Completed
NCT02840162Knight TherapeuticsCelecoxib

Pre-Prostatectomy Celecoxib or Placebo

Start: May 2001Est. completion: May 201134 patients
Phase 2Terminated
NCT02234921Providence TherapeuticsCyclophosphamide

Pilot Study of DRibble Vaccine for Prostate Cancer Patients

Start: Oct 2014Est. completion: Aug 2018
Phase 1Completed
NCT01913015Knight Therapeuticsabiraterone acetate

Dietary Fat Levels and Abiraterone Acetate Uptake in Patients With Metastatic Hormone-Resistant Prostate Cancer

Start: Jul 20133 patients
Phase 1Terminated

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
9 companies competing in this space

Related Indications

Breast Cancer(530)Non-small Cell Lung Cancer(373)Prostate Cancer(371)Multiple Myeloma(244)Advanced Solid Tumors(221)Acute Myeloid Leukemia(204)Cancer(187)Neoplasms(173)Colorectal Cancer(166)Advanced Solid Tumor(165)