Acute Heart Failure

Cardiovascular
4
Pipeline Programs
7
Companies
10
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
2
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Abbott
AbbottABBOTT PARK, IL
3 programs
1
levosimendanPhase 31 trial
Determining When Patients Hospitalized With Acute Heart Failure Can Be Safely Sent Home (The DECIDE N/A1 trial
Transthoracic EchocardiogramN/A1 trial
Active Trials
NCT00911703Completed835Est. Oct 2015
NCT02728739Completed500Est. Feb 2018
NCT00348504Completed1,300Est. Jun 2005
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
Empagliflozin 10 MGPhase 31 trial
Active Trials
NCT05392764Recruiting444Est. Dec 2027
Novartis
NovartisBASEL, Switzerland
2 programs
1
SerelaxinPhase 21 trial
Global Non-interventional Heart Failure Disease RegistryN/A1 trial
Active Trials
NCT02595814Terminated18,805Est. Mar 2018
NCT02151383Terminated12Est. Apr 2017
Innogene Kalbiotech
Innogene KalbiotechSingapore - Singapore
1 program
1
0.5M Sodium lactatePhase 21 trial
Active Trials
NCT01981655CompletedEst. Aug 2013
Montis Biosciences
Montis BiosciencesBelgium - Leuven
1 program
Continuous Furosemide InfusionN/A1 trial
Active Trials
NCT02638142RecruitingEst. Jan 2028
Rhythm Pharmaceuticals
1 program
Intensive insulin infusionN/A1 trial
Active Trials
NCT00922402Withdrawn0Est. Sep 2011
Roche
RocheSTAVANGER NORWAY, Norway
1 program
Registry Of Best Up-titration STrategies in Acute Heart FailureN/A1 trial
Active Trials
NCT05865665Not Yet Recruiting5,000Est. Dec 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Boehringer IngelheimEmpagliflozin 10 MG
Abbottlevosimendan
NovartisSerelaxin
Innogene Kalbiotech0.5M Sodium lactate
RocheRegistry Of Best Up-titration STrategies in Acute Heart Failure
AbbottTransthoracic Echocardiogram
Montis BiosciencesContinuous Furosemide Infusion
NovartisGlobal Non-interventional Heart Failure Disease Registry
Rhythm PharmaceuticalsIntensive insulin infusion
AbbottDetermining When Patients Hospitalized With Acute Heart Failure Can Be Safely Sent Home (The DECIDE

Clinical Trials (10)

Total enrollment: 26,896 patients across 10 trials

NCT05392764Boehringer IngelheimEmpagliflozin 10 MG

Early Treatment With a Sodium-glucose Co-transporter 2 Inhibitor in High-risk Patients With Acute Heart Failure

Start: Sep 2022Est. completion: Dec 2027444 patients
Phase 3Recruiting
NCT00348504Abbottlevosimendan

Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support: a Multicentre, Parallel-Group, Randomised, Double-Blind, Double-Dummy Study of Levosimendan Versus Dobutamine in Patients With Acute Heart Failure.

Start: Mar 2003Est. completion: Jun 20051,300 patients
Phase 3Completed
NCT02151383NovartisSerelaxin

Pharmacokinetics & Safety of Serelaxin on Top of Standard of Care Therapy in Pediatric Patients With Acute Heart Failure

Start: Sep 2014Est. completion: Apr 201712 patients
Phase 2Terminated
NCT01981655Innogene Kalbiotech0.5M Sodium lactate

0.5M Na Lactate Solution in Acute Heart Failure (AHF)

Start: Dec 2009Est. completion: Aug 2013
Phase 2Completed
NCT05865665RocheRegistry Of Best Up-titration STrategies in Acute Heart Failure

Registry Of Best Up-titration STrategies in Acute Heart Failure

Start: Jun 2023Est. completion: Dec 20275,000 patients
N/ANot Yet Recruiting
NCT02728739AbbottTransthoracic Echocardiogram

Incidence of Significant Mitral Regurgitation in Acute Heart Failure Patients

Start: Jun 2016Est. completion: Feb 2018500 patients
N/ACompleted
NCT02638142Montis BiosciencesContinuous Furosemide Infusion

Loop Diuretic Therapy in Acutely Decompensated Heart Failure

Start: Dec 2015Est. completion: Jan 2028
N/ARecruiting
NCT02595814NovartisGlobal Non-interventional Heart Failure Disease Registry

Global Non-interventional Heart Failure Disease Registry

Start: Jul 2014Est. completion: Mar 201818,805 patients
N/ATerminated
NCT00922402Rhythm PharmaceuticalsIntensive insulin infusion

Heart & Diabetes - Feasibility Study

Start: Jun 2009Est. completion: Sep 20110
N/AWithdrawn
NCT00911703AbbottDetermining When Patients Hospitalized With Acute Heart Failure Can Be Safely Sent Home (The DECIDE

Determining When Patients Hospitalized With Acute Heart Failure Can Be Safely Sent Home (The DECIDE Study)

Start: Aug 2008Est. completion: Oct 2015835 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 26,896 patients
7 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)