Carbon Biosciences

MA - Waltham

Biotechnology1 H-1B visas (FY2023)

Website LinkedIn Careers Page

Focus: Gene Therapy

Carbon Biosciences is a life sciences company focused on Gene Therapy.

Gene Therapy

Funding Stage

PUBLIC

Open Jobs

Products & Portfolio (4)

1 discontinued product not shown

X-Ray Contrast Activity

X-Ray Contrast Activity

CLINICAL PHARMACOLOGY Isoflurane is an inhalation anesthetic. The MAC (minimum alveolar concentration) in man is as follows: Age 100% Oxygen 70% N 2 O 26 ± 4 1.28 0.56 44 ± 7 1.15 0.50 64 ± 5 1.05 0.37 Induction of and recovery from isoflurane anesthesia are rapid. Isoflurane has a mild pungency which limits the rate of induction, although excessive salivation or tracheobronchial secretions do not appear to be stimulated. Pharyngeal and laryngeal reflexes are readily obtunded. The level of anesthesia may be changed rapidly with isoflurane. Isoflurane is a profound respiratory depressant. RESPIRATION MUST BE MONITORED CLOSELY AND SUPPORTED WHEN NECESSARY. As anesthetic dose is increased, tidal volume decreases and respiratory rate is unchanged. This depression is partially reversed by surgical stimulation, even at deeper levels of anesthesia. Isoflurane evokes a sigh response reminiscent of that seen with diethyl ether and enflurane, although the frequency is less than with enflurane. Blood pressure decreases with induction of anesthesia but returns toward normal with surgical stimulation. Progressive increases in depth of anesthesia produce corresponding decreases in blood pressure. Nitrous oxide diminishes the inspiratory concentration of isoflurane required to reach a desired level of anesthesia and may reduce the arterial hypotension seen with isoflurane alone. Heart rhythm is remarkably stable. With controlled ventilation and normal PaCO 2 , cardiac output is maintained despite increasing depth of anesthesia primarily through an increase in heart rate which compensates for a reduction in stroke volume. The hypercapnia which attends spontaneous ventilation during isoflurane anesthesia further increases heart rate and raises cardiac output above awake levels. Isoflurane does not sensitize the myocardium to exogenously administered epinephrine in the dog. Limited data indicate that subcutaneous injection of 0.25mg of epinephrine (50 mL of 1:200,000 solution) does not produce an increase in ventricular arrhythmias in patients anesthetized with isoflurane. Muscle relaxation is often adequate for intra-abdominal operations at normal levels of anesthesia. Complete muscle paralysis can be attained with small doses of muscle relaxants. ALL COMMONLY USED MUSCLE RELAXANTS ARE MARKEDLY POTENTIATED WITH ISOFLURANE, THE EFFECT BEING MOST PROFOUND WITH THE NONDEPOLARIZING TYPE. Neostigmine reverses the effect of nondepolarizing muscle relaxants in the presence of isoflurane. All commonly used muscle relaxants are compatible with isoflurane. Isoflurane can produce coronary vasodilation at the arteriolar level in selected animal models; the drug is probably also a coronary dilator in humans. Isoflurane, like some other coronary arteriolar dilators, has been shown to divert blood from collateral dependent myocardium to normally perfused areas in an animal model ("coronary steal"). Clinical studies to date evaluating myocardial ischemia, infarction and death as

Pipeline & Clinical Trials

BCT Antimicrobial Dressing

Burns

N/A

Clinical Trials (1)

NCT01598493To Study the Healing Effect of Silver Impregnated Activated Carbon Fiber Wound Dressing on Deep Dermal Burn

N/A

Acticoat Absorbent

Wound Healing

N/A

Clinical Trials (1)

NCT01769144Acticoat Absorbent and BCT Antimicrobial for STSG Donor Site on Thigh

N/A

RCT 1- Testing the Effectiveness of Marketing Messages in Increasing Willingness to Pay

Air Pollution, Indoor

N/A

Clinical Trials (1)

NCT01611350Testing New Marketing Models for Improved Cookstoves - Uganda

N/A

Flamazine

Burns

N/A

Clinical Trials (1)

NCT01598480To Study the Healing Effect of Silver Impregnated Activated Carbon Fiber Wound Dressing on Superficial Dermal Burn

N/A

Vaginal swab for RT-PCR

Vaginal Infection

N/A

Clinical Trials (1)

NCT05557318Using Micro Electro Mechanical Systems to Detect the Air of Vaginal Discharge

N/A

BCT Silver Bandage

Surgical Wound

N/A

Clinical Trials (1)

NCT01605968A Comparative Efficacy and Safety Study Between Two Silver Containing Dressings In Post-Op Wound Healing

N/A

hydrophilic-based dressing

Wounds

N/A

Clinical Trials (1)

NCT01921725The Clinical Application and Efficacy Verification of an Innovative Carbon Fiber Dressing

N/A

Needle Guided Periurethral Injection

Urinary Incontinence

Phase 1

Clinical Trials (1)

NCT00763711Injectable Bulking Agent Needle Guide

Phase 1

TH9619

Solid Tumor

Phase 1/2

Clinical Trials (1)

NCT07151040Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors

Phase 1/2

Durasphere FI

Fecal Incontinence

Phase 2

Clinical Trials (1)

NCT00762047A Prospective, Multi-center, Randomized, Blinded Study to Evaluate Durasphere FI for the Treatment of Fecal Incontinence

Phase 2

Amniotic Tissue Allograft

Chronic Wounds

Phase 3

Clinical Trials (1)

NCT07223892Efficacy of Carbonlife Amniotic Tissue Product in the Treatment of Chronic Wounds

Phase 3

Open Jobs (0)

No open positions listed yet. Check their careers page directly.

Interview Prep Quick Facts

Portfolio: 5 approved products, 11 clinical trials

Top TAs: Neurology

H-1B (2023): 1 approval

Portfolio Health

Peak2 (40%)

Post-LOE3 (60%)

5 total products

Therapeutic Area Focus

Neurology

2 marketed

Marketed

Pipeline

Hiring Trend

Stable

Open Roles

Added

-0

Filled/Removed

Based on last 4 crawl cycles

Visa Sponsorship

Sponsors Work Visas

H-1B Petitions (FY2023)

Approved

Denied

100%

Rate

Source: USCIS H-1B Employer Data Hub