Pulmonary Hypertension Associated With HFpEF

Cardiovascular
3
Pipeline Programs
2
Companies
3
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
3
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Tenax Therapeutics
Tenax TherapeuticsCHAPEL HILL, NC
2 programs
2
TNX-103Phase 31 trial
TNX-103Phase 31 trial
Active Trials
NCT07288398RecruitingEst. Jun 2029
NCT07436689Enrolling By InvitationEst. Mar 2029
United Therapeutics
United TherapeuticsMD - Silver Spring
1 program
1
Oral treprostinilPhase 31 trial
Active Trials
NCT03043651Terminated48Est. Mar 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Tenax TherapeuticsTNX-103
Tenax TherapeuticsTNX-103
United TherapeuticsOral treprostinil

Clinical Trials (3)

Total enrollment: 48 patients across 3 trials

NCT07436689Tenax TherapeuticsTNX-103

Long-Term Open-Label Extension Study of Oral Levosimendan

Start: Mar 2026Est. completion: Mar 2029
Phase 3Enrolling By Invitation
NCT07288398Tenax TherapeuticsTNX-103

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

Start: Dec 2025Est. completion: Jun 2029
Phase 3Recruiting
NCT03043651United TherapeuticsOral treprostinil

Open-label Extension of Oral Treprostinil in Subjects With PH Associated With HFpEF

Start: Jan 2018Est. completion: Mar 202048 patients
Phase 3Terminated

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 48 patients
2 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)