Peripheral Artery Disease

Cardiovascular
7
Pipeline Programs
9
Companies
23
Clinical Trials
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
3
0
0
3
Early DiscoveryClinical DevelopmentMarket

On Market (2)

Approved therapies currently available

AstraZeneca
BRILINTAApproved
ticagrelor
AstraZeneca
P2Y12 Platelet Inhibitor [EPC]oral2011
U
TICAGRELORApproved
ticagrelor
Unknown Company
P2Y12 Platelet Inhibitor [EPC]oral2025

Competitive Landscape

9 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
TicagrelorPhase 41 trial
Active Trials
NCT02121288Withdrawn0Est. Feb 2016
Biotronik
BiotronikGermany - Berlin
7 programs
2
Astron StentsPhase 21 trial
MAGIC EXPLORERPhase 21 trial
Astron/Pulsar-18 stentN/A1 trial
BRight DCBN/A1 trial
BRight DCBN/A1 trial
+2 more programs
Active Trials
NCT01661231Unknown456Est. Oct 2018
NCT06065345Completed6Est. Jul 2025
NCT04525794Completed48Est. Feb 2024
+4 more trials
C
CordisFL - Miami Lakes
3 programs
1
drug-eluting stentPhase 21 trial
FlexStent® Femoropopliteal Self Expanding Stent SystemN/A1 trial
PMCF Study for Peripheral Arteries Below the Knee (BTK)N/A1 trial
Active Trials
NCT01355406Completed257Est. Apr 2018
NCT05444660Completed102Est. Nov 2022
NCT00232869Completed93Est. May 2009
Takeda
TakedaTOKYO, Japan
1 program
1
PVS-10200Phase 1/21 trial
Active Trials
NCT01099215Completed21Est. Oct 2012
Abbott
AbbottABBOTT PARK, IL
7 programs
Diamondback 360 Extended Length Orbital Atherectomy SystemN/A1 trial
Orbital Atherectomy SystemN/A1 trial
Peripheral Orbital Atherectomy SystemN/A1 trial
Physical activity levelsN/A1 trial
SUPERA Interwoven self-expanding nitinol stentN/A1 trial
+2 more programs
Active Trials
NCT03943160Completed50Est. Dec 2019
NCT01941030Completed51Est. Jun 2015
NCT05529472Completed81Est. Oct 2024
+4 more trials
Bayer
BayerLEVERKUSEN, Germany
1 program
ABI measurementN/A1 trial
Active Trials
NCT03921905Completed713Est. Nov 2023
M&
Merck & Co.RAHWAY, NJ
1 program
Decision Support ToolN/A1 trial
Active Trials
NCT03190382Completed72Est. Apr 2024
Alliance Pharmaceuticals
1 program
SELUTION SLR™N/A1 trial
Active Trials
NCT04776434Active Not Recruiting723Est. Dec 2028
Pulse Biosciences
Pulse BiosciencesCA - Hayward
1 program
control foodsN/A1 trial
Active Trials
NCT01382056CompletedEst. Dec 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
AstraZenecaTicagrelor
BiotronikAstron Stents
BiotronikMAGIC EXPLORER
Cordisdrug-eluting stent
TakedaPVS-10200
BiotronikBRight DCB
AbbottPeripheral Orbital Atherectomy System
CordisPMCF Study for Peripheral Arteries Below the Knee (BTK)
BiotronikBallon expandable stent and PTA
Alliance PharmaceuticalsSELUTION SLR™
BiotronikBRight DCB
BayerABI measurement
AbbottDiamondback 360 Extended Length Orbital Atherectomy System
Merck & Co.Decision Support Tool
BiotronikBiotronik 4 French Portfolio

Showing 15 of 23 trials with date data

Clinical Trials (23)

Total enrollment: 6,600 patients across 23 trials

NCT02121288AstraZenecaTicagrelor

Adenosine-induced Myocardial Blood Flow in Peripheral Artery Disease Patients

Start: Dec 2014Est. completion: Feb 20160
Phase 4Withdrawn
NCT01319812BiotronikAstron Stents

Investigational Device Exemption Study to Determine the Safety and Efficacy of the Astron and Pulsar Stents

Start: Jul 2011Est. completion: Sep 2017463 patients
Phase 2Completed
NCT00572494BiotronikMAGIC EXPLORER

AMS INSIGHT 1 Study - Bioabsorbable Metal Stent Investigation in Chronic Limb Ischemia Treatment

Start: Jul 2005Est. completion: Jan 2007117 patients
Phase 2Completed
NCT00232869Cordisdrug-eluting stent

A Study of the SMART Stent in the Treatment SFA Disease.

Start: Feb 2001Est. completion: May 200993 patients
Phase 2Completed
NCT01099215TakedaPVS-10200

Study of PVS-10200 for the Treatment of Restenosis in Patients With Peripheral Artery Disease (TRIUMPH)

Start: Apr 2010Est. completion: Oct 201221 patients
Phase 1/2Completed
NCT06065345BiotronikBRight DCB

BRight Pharmacokinetic Study

Start: May 2024Est. completion: Jul 20256 patients
N/ACompleted
NCT05529472AbbottPeripheral Orbital Atherectomy System

Safety and Effectiveness Evaluation of Peripheral Orbital Atherectomy

Start: Jan 2023Est. completion: Oct 202481 patients
N/ACompleted
NCT05444660CordisPMCF Study for Peripheral Arteries Below the Knee (BTK)

PMCF Study for Peripheral Arteries Below the Knee (BTK)

Start: May 2022Est. completion: Nov 2022102 patients
N/ACompleted
NCT04830228BiotronikBallon expandable stent and PTA

BIOTRONIK Dynetic-35 Stent for the Treatment of Peripheral Iliac Lesions

Start: Aug 2021Est. completion: Feb 2028160 patients
N/AActive Not Recruiting
NCT04776434Alliance PharmaceuticalsSELUTION SLR™

SUCCESS (SelUtion, Safety, effiCaCy, hEalth economicS and promS) PTA Study

Start: Feb 2021Est. completion: Dec 2028723 patients
N/AActive Not Recruiting
NCT04525794BiotronikBRight DCB

BRight DCB First-in-Human Study

Start: Feb 2021Est. completion: Feb 202448 patients
N/ACompleted
NCT03921905BayerABI measurement

Peripheral Artery Disease in Patients With Stable Coronary Artery Disease in General Practice: Prevalence, Management and Clinical Outcomes.

Start: Sep 2019Est. completion: Nov 2023713 patients
N/ACompleted
NCT03943160AbbottDiamondback 360 Extended Length Orbital Atherectomy System

Radial accEss for nAvigation to Your CHosen Lesion for Peripheral Vascular Intervention: REACH PVI

Start: Jun 2019Est. completion: Dec 201950 patients
N/ACompleted
NCT03190382Merck & Co.Decision Support Tool

SHOWME-PAD (Peripheral Artery Disease)

Start: Jun 2017Est. completion: Apr 202472 patients
N/ACompleted
NCT03044002BiotronikBiotronik 4 French Portfolio

BIOTRONIK 4French for AMBulatory Peripheral Intervention

Start: Mar 2017Est. completion: Oct 2020821 patients
N/ACompleted
NCT03048890AbbottPhysical activity levels

VascTrac Peripheral Arterial Disease (PAD) Study

Start: Mar 2017Est. completion: Dec 20232,000 patients
N/AUnknown
NCT01941030AbbottOrbital Atherectomy System

Complete Lesion Assessment With ffR and IVUS TechnologY

Start: Mar 2013Est. completion: Jun 201551 patients
N/ACompleted
NCT01938391AbbottStealth 360°® OAS

Tissue Removal Assessment With Ultrasound of THe SFA and Popliteal

Start: Jan 2013Est. completion: Feb 201525 patients
N/ACompleted
NCT01661231BiotronikAstron/Pulsar-18 stent

Study to Determine the Performance of the Astron and Pulsar-18 Stents in Europe

Start: Oct 2012Est. completion: Oct 2018456 patients
N/AUnknown
NCT01382056Pulse Biosciencescontrol foods

Effects of Pulse Varieties on Blood Vessel Function in Peripheral Artery Disease

Start: Mar 2012Est. completion: Dec 2013
N/ACompleted
NCT01444378AbbottStenting using Absolute Pro® and Pro LL® Peripheral Stent Systems

Absolute Pro® MOMENTUM™

Start: Oct 2011Est. completion: May 2015141 patients
N/ACompleted
NCT01355406CordisFlexStent® Femoropopliteal Self Expanding Stent System

Evaluation of Safety and Efficacy of the FlexStent® Femoropopliteal Self-Expanding Stent System

Start: Sep 2011Est. completion: Apr 2018257 patients
N/ACompleted
NCT01154751AbbottSUPERA Interwoven self-expanding nitinol stent

Data Registry Following Patients Using Supera Stent in the Femoral Arteries

Start: Nov 2008Est. completion: Aug 2015200 patients
N/ATerminated

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

9 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)