Myopia

Ophthalmology
13
Pipeline Programs
13
Companies
50
Clinical Trials
5 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
3
8
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

13 companies ranked by most advanced pipeline stage

Alcon
AlconFORT WORTH, TX
52 programs
1
7
Excimer LasersPhase 41 trial
FS200 Femtosecond LaserPhase 41 trial
ReNu MultiPlus® MultiPurpose SolutionPhase 41 trial
Soft contact lensPhase 41 trial
bilateral myopic LASIKPhase 41 trial
+47 more programs
Active Trials
NCT01594294Completed100Est. Jun 2013
NCT01100411CompletedEst. Jul 2010
NCT01634659CompletedEst. Sep 2012
+48 more trials
Bausch + Lomb
Bausch + LombNJ - Bridgewater
34 programs
1
1
PureVision Contact LensPhase 41 trial
Currently Marketed PureVision Contact Lens.Phase 31 trial
217z LaserN/A1 trial
B&L Investigational Contact LensN/A1 trial
B&L RD2135-01 lens CN/A1 trial
+29 more programs
Active Trials
NCT00347997Withdrawn0
NCT01449526Completed166Est. Jan 2012
NCT01583868Completed216Est. Jul 2012
+31 more trials
Abbott
AbbottABBOTT PARK, IL
3 programs
1
LASIK correction of myopic refractive errorsPhase 31 trial
Complete Easy Rub Formula MPSN/A1 trial
VSS-Rx1 OPM vs Commercial iDesign TreatmentN/A1 trial
Active Trials
NCT01019564Withdrawn0Est. Mar 2010
NCT01988415Completed26Est. Jul 2014
NCT01663363Completed170Est. Jul 2015
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
1 program
1
QLM3004 Concentration 1Phase 31 trial
Active Trials
NCT06151587RecruitingEst. Jun 2027
S
SantenCA - Emeryville
2 programs
1
DE-127 Ophthalmic Solution low dosePhase 21 trial
Non-InterventionN/A1 trial
Active Trials
NCT06912802Recruiting350Est. Dec 2025
NCT03329638Completed99Est. Apr 2020
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
14 programs
1 Day Acuvue MoistN/A1 trial
Acuvue Advance Plus prePQN/A1 trial
Cheetah SystemN/A1 trial
InterventionN/A1 trial
Narafilcon B Contact LensN/A1 trial
+9 more programs
Active Trials
NCT01829230Completed82Est. Oct 2011
NCT01244893Completed44
NCT04200898Completed286Est. Dec 2024
+19 more trials
Glaukos
GlaukosALISO VIEJO, CA
6 programs
4.0 mm treatmentN/A1 trial
CXL MyopiaN/A1 trial
LasikXtraN/A1 trial
PiXLN/A1 trial
PiXLN/A1 trial
+1 more programs
Active Trials
NCT03987880CompletedEst. Oct 2020
NCT02872766TerminatedEst. Jan 2018
NCT03913338CompletedEst. Jul 2018
+3 more trials
STAAR Surgical
STAAR SurgicalCA - Lake Forest
4 programs
EVO ICLN/A1 trial
EVO/EVO+ Visian ICLN/A1 trial
Implantable Collamer LensN/A1 trial
the implantation of toric implantable collamer lensN/A1 trial
Active Trials
NCT05538754CompletedEst. Oct 2023
NCT04283149CompletedEst. Dec 2023
NCT07291739CompletedEst. Oct 2024
+1 more trials
Seed Therapeutics
Seed TherapeuticsNY - New York
3 programs
Breath-O orthokeratology lensesN/A1 trial
Breath-O-Correct LensN/A1 trial
SEED 1-dayPure EDOF soft contact lensN/A1 trial
Active Trials
NCT03919396CompletedEst. Dec 2022
NCT03616600CompletedEst. Jan 2019
NCT04618510UnknownEst. Aug 2022
Plus Therapeutics
3 programs
Defocus-enhanced spectaclesN/A
Oral swab DNA analyzed for myopia-related gene variantsN/A
Wavelight Plus Alcon systemN/A
Alliance Pharmaceuticals
2 programs
Oral swab DNA analyzed for myopia-related gene variantsN/A1 trial
Wavelight Plus Alcon systemN/A1 trial
Active Trials
NCT07030153Recruiting1,000Est. Dec 2028
NCT06788418Recruiting1,000Est. Dec 2025
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
Bausch + Lomb Samfilcon A Soft Contact LensN/A1 trial
Active Trials
NCT02939950CompletedEst. Aug 2016
Novartis
NovartisBASEL, Switzerland
1 program
Topography Guided LASIKN/A1 trial
Active Trials
NCT02987660Terminated21Est. Jul 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Johnson & Johnsonsenofilcon A
AlconFS200 Femtosecond Laser
Alconbilateral myopic LASIK
AlconReNu MultiPlus® MultiPurpose Solution
Alconlotrafilcon A contact lenses
AlconExcimer Lasers
Bausch + LombPureVision Contact Lens
AlconSoft contact lens
Alconsoft contact lens
Qilu PharmaceuticalQLM3004 Concentration 1
AbbottLASIK correction of myopic refractive errors
Bausch + LombCurrently Marketed PureVision Contact Lens.
SantenDE-127 Ophthalmic Solution low dose
Johnson & Johnsonsenofilcon A
AlconLenSx Laser

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 7,094 patients across 50 trials

NCT03222037Johnson & Johnsonsenofilcon A

Evaluation of Electronic LogMar Visual Acuity and Contrast Sensitivity in a Population of Contact Lens Wearers

Start: Jun 2017Est. completion: Aug 201749 patients
Phase 4Completed
NCT01693939AlconFS200 Femtosecond Laser

Evaluation of the Post-LASIK Flap Thickness of the FS200 Femtosecond Laser Flap

Start: Feb 2012Est. completion: Apr 2012
Phase 4Completed
NCT01746589Alconbilateral myopic LASIK

Visual Outcomes and Contrast Sensitivity After Myopic LASIK

Start: Nov 2011Est. completion: Jan 2012
Phase 4Completed
NCT01250925AlconReNu MultiPlus® MultiPurpose Solution

Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface

Start: Aug 2010Est. completion: Jul 2012
Phase 4Completed
NCT00937105Alconlotrafilcon A contact lenses

Daily Wear Corneal Infiltrative Event Study

Start: Nov 2009Est. completion: Feb 2012
Phase 4Completed
NCT00770094AlconExcimer Lasers

Multi Laser Platform Comparison Study for LASIK

Start: Oct 2008Est. completion: Feb 2009
Phase 4Unknown
NCT00640341Bausch + LombPureVision Contact Lens

Comparative Performance of PureVision, Acuvue Oasys and O2Optix

Start: Feb 2008Est. completion: Apr 2008510 patients
Phase 4Completed
NCT00349843AlconSoft contact lens

Investigation of Multi-Purpose Solution-Based Corneal Staining and Ocular Comfort

Start: Jun 2005
Phase 4Completed
NCT00349882Alconsoft contact lens

Effects of Contact Lens Care Regimens on the Corneal Epithelium

Start: Jun 2005
Phase 4Completed
NCT06151587Qilu PharmaceuticalQLM3004 Concentration 1

A Phase 3 Clinical Study of QLM3004 in Delaying Myopia in Children

Start: Aug 2023Est. completion: Jun 2027
Phase 3Recruiting
NCT01663363AbbottLASIK correction of myopic refractive errors

Safety and Effectiveness of Wavefront-Guided LASIK Corrections of Myopic Refractive Errors

Start: Aug 2012Est. completion: Jul 2015170 patients
Phase 3Completed
NCT00661687Bausch + LombCurrently Marketed PureVision Contact Lens.

Comparative Performance of PureVision Lens Designs

Start: Dec 2007Est. completion: Jun 2008206 patients
Phase 3Completed
NCT03329638SantenDE-127 Ophthalmic Solution low dose

A Study Assessing the Efficacy and Safety of DE-127 Ophthalmic Solution in Subjects With Mild or Moderate Myopia (APPLE)

Start: Oct 2017Est. completion: Apr 202099 patients
Phase 2Completed
NCT03330275Johnson & Johnsonsenofilcon A

Evaluating the Impact of JJVC Senofilcon A - Based Contact Lens With New UV-blocker on Day and Night Driving Performance

Start: Sep 2017Est. completion: Dec 201724 patients
Phase 2Completed
NCT01556893AlconLenSx Laser

Creating LASIK Flaps With the LenSx Femtosecond Laser

Start: Apr 2012Est. completion: Mar 2013
Phase 1Completed
NCT00347997Bausch + Lomb217z Laser

A Study to Evaluate the Safety and Effectiveness of the 217z Laser With Zyoptix for Lasik

0
N/AWithdrawn
NCT06618547Bausch + LombTENEO 317 Model 2 excimer laser

Effectiveness and Safety of the TENEO 317 Model 2 Excimer Laser to Treat Myopia With or Without Astigmatism by Transepithelial Photorefractive Keratectomy

Start: Nov 2025Est. completion: Nov 2026140 patients
N/ANot Yet Recruiting
NCT06912802SantenNon-Intervention

Observational Survey Study on the Impact of Myopia and Its Complications on Quality of Life.

Start: Jul 2025Est. completion: Dec 2025350 patients
N/ARecruiting
NCT07030153Alliance PharmaceuticalsOral swab DNA analyzed for myopia-related gene variants

Association of Genetic Variants With Myopia

Start: Jul 2025Est. completion: Dec 20281,000 patients
N/ARecruiting
NCT06788418Alliance PharmaceuticalsWavelight Plus Alcon system

Comparative Study of SMILE, ICL, and Wavelight Plus Alcon Technologies in Myopia Correction

Start: Jan 2025Est. completion: Dec 20251,000 patients
N/ARecruiting
NCT06749496Johnson & Johnsonsenofilcon A

Evaluation of Delefilcon A and Senofilcon A Daily Disposable Toric Soft Contact Lenses Over One Week of Wear

Start: Jan 2025Est. completion: Mar 2025134 patients
N/ACompleted
NCT06483113AlconDelefilcon A spherical soft contact lenses

DAILIES TOTAL1® Soft Contact Lenses - Post-Market Clinical Follow-up Study

Start: Nov 2024Est. completion: Feb 2025192 patients
N/ATerminated
NCT06377488Johnson & Johnsonsenofilcon A

Evaluation of the Clinical Performance of Daily Disposable Silicone Hydrogel Multifocal Toric Contact Lenses

Start: Apr 2024Est. completion: Jun 2024176 patients
N/ACompleted
NCT06305663Bausch + LombBausch + Lomb

A Study to Evaluate the Safety and Efficacy of the Bausch + Lomb Myopia Control Lens for the Correction of Myopic Ametropia and Slowing the Progression of Myopia in Children

Start: Mar 2024Est. completion: Jan 2027418 patients
N/ARecruiting
NCT06308666AlconDelefilcon A contact lenses

Performance of DAILIES TOTAL1 Daily Disposable Contact Lenses in Habitual Soft Lens Wearers Who Report Substantial Digital Device Use

Start: Mar 2024Est. completion: Oct 2024
N/ACompleted
NCT06075576Johnson & JohnsonIntervention

Characterization of the Central and Peripheral Wavefront Aberration Profile in Pediatric Myopic Subjects

Start: Nov 2023Est. completion: Aug 202523 patients
N/ACompleted
NCT05984290Bausch + Lomborthokeratology lens

Study of Safety and Effectiveness of the Boston Orthokeratology Shaping Lens in the Arise Orthokeratology Lens

Start: Jul 2023Est. completion: Jun 202490 patients
N/ACompleted
NCT05538754STAAR SurgicalEVO ICL

Post-Market Evaluation of the EVO ICL

Start: Sep 2022Est. completion: Oct 2023
N/ACompleted
NCT07291739STAAR SurgicalImplantable Collamer Lens

A Clinical Evaluation of a Phakic Intraocular Lens

Start: Aug 2022Est. completion: Oct 2024
N/ACompleted
NCT05320042Bausch + Lombkalifilcon A Daily Disposable Toric

1-Week Dispensing Evaluation of Kalifilcon A Toric Contact Lenses Compared to Ultra for Astigmatism

Start: Feb 2022Est. completion: May 202228 patients
N/ACompleted
NCT05101252Johnson & Johnsonsenofilcon A

Comparison of a Daily Disposable Multifocal Contact Lens to a Marketed Product

Start: Oct 2021Est. completion: Nov 202177 patients
N/ACompleted
NCT05099380Johnson & Johnsonsenofilcon A

Validation of Senofilcon A With New UV / HEV Filter

Start: Oct 2021Est. completion: Nov 2021296 patients
N/ACompleted
NCT04980456AlconLehfilcon A contact lenses

Clinical Assessment of Two Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lenses

Start: Aug 2021Est. completion: Nov 2021257 patients
N/ACompleted
NCT04618510Seed TherapeuticsSEED 1-dayPure EDOF soft contact lens

SEED-LVPEI Myopia Study

Start: Dec 2020Est. completion: Aug 2022
N/AUnknown
NCT04219891AlconWaveLight EX500 excimer laser system with InnovEyes sightmap

WaveLight® EX500 Excimer Laser System for the Correction of Myopia Using InnovEyes™ in Conjunction With InnovEyes™ Sightmap

Start: Mar 2020Est. completion: Nov 2022272 patients
N/ACompleted
NCT04283149STAAR SurgicalEVO/EVO+ Visian ICL

Multicenter Clinical Trial of a Phakic Implantable Collamer® Lens (ICL)

Start: Jan 2020Est. completion: Dec 2023
N/ACompleted
NCT04200898Johnson & JohnsonCheetah System

Clinical Investigation of the Cheetah System For The Correction of Myopia With and Without Astigmatism

Start: Dec 2019Est. completion: Dec 2024286 patients
N/ACompleted
NCT04205162AlconVerafilcon A

Evaluating the Initial Lens Handling Experience of Neophyte Contact Lens Wearers Fitted With Precision1 and 1-Day Acuvue Moist Contact Lenses

Start: Dec 2019Est. completion: Jun 2022
N/ACompleted
NCT04901897Bausch + Lombkalifilcon A

Product Performance of a New Silicone Hydrogel Contact Lens

Start: Jul 2019Est. completion: Oct 2019805 patients
N/ACompleted
NCT04111757Bausch + LombTechnolas® TENEO 317 Model 2

A Study With Technolas® TENEO 317 Model 2 Excimer Laser to Treat Participants With Myopia or Myopic Astigmatism

Start: Jul 2019Est. completion: Aug 2021168 patients
N/ACompleted
NCT03919396Seed TherapeuticsBreath-O orthokeratology lenses

Effectiveness of Myopia Control by Breath-O Correct Orthokeratology Lenses

Start: Apr 2019Est. completion: Dec 2022
N/ACompleted
NCT04663048GlaukosPiXL

PiXL as a Treatment for Low Grade Myopia

Start: Feb 2019Est. completion: Jun 2024
N/AUnknown
NCT03787472Johnson & Johnsonsenofilcon A

Clinical Evaluation of Manufacturing Processes for a Reusable Multifocal Optical Design in a Presbyopic Population

Start: Jan 2019Est. completion: Mar 201945 patients
N/ACompleted
NCT03742271Johnson & Johnsonsenofilcon A

Evaluation of Senofilcon A With New UV-blocker on a Neophyte Population

Start: Oct 2018Est. completion: Mar 2019130 patients
N/ACompleted
NCT03628599AlconDelefilcon A contact lenses

Two Daily Disposable Contact Lenses in Symptomatic Patients

Start: Aug 2018Est. completion: Sep 201839 patients
N/ACompleted
NCT03597178Johnson & Johnsonsenofilcon A

Contact Lens Insertion and Removal in a Senior Subject Demographic

Start: Jun 2018Est. completion: Jul 201816 patients
N/ACompleted
NCT03556579Johnson & Johnsonsenofilcon A

The Effects of Contact Lenses With Experimental Dye on Visual Function

Start: May 2018Est. completion: Sep 201862 patients
N/ACompleted
NCT04096898Johnson & Johnsonsenofilcon A

Senofilcon A Lenses in Moderate to Severe Dry Eye Disease

Start: Apr 2018Est. completion: Dec 202032 patients
N/AUnknown
NCT03616600Seed TherapeuticsBreath-O-Correct Lens

The Safety and Effectiveness of Breath-O Lenses

Start: Mar 2018Est. completion: Jan 2019
N/ACompleted
NCT03987880Glaukos4.0 mm treatment

Photorefractive Intrastromal Corneal Crosslinking as a Treatment for Low Grade Myopia

Start: Jan 2018Est. completion: Oct 2020
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
5 actively recruiting trials targeting 7,094 patients
13 companies competing in this space

Related Indications

Cataract(116)Open-Angle Glaucoma(102)Glaucoma(92)Dry Eye(74)Age-Related Macular Degeneration(73)Dry Eye Disease(43)Neovascular Age-related Macular Degeneration(40)Macular Degeneration(37)Diabetic Retinopathy(25)Cataracts(22)