Macular Degeneration

Ophthalmology
32
Pipeline Programs
15
Companies
50
Clinical Trials
1 recruiting
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
6
1
7
0
12
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
563%
Small Molecule
338%
+ 29 programs with unclassified modality

On Market (4)

Approved therapies currently available

U
ALPROSTADILApproved
alprostadil
Unknown Company
Prostaglandin Analog [EPC]injection1999
U
EDEXApproved
alprostadil
Unknown Company
Prostaglandin Analog [EPC]injection1997
Regeneron
EYLEAApproved
aflibercept
Regeneron
Vascular Endothelial Growth Factor Inhibitor [EPC]injection2011
Regeneron
EYLEA HDApproved
aflibercept
Regeneron
Vascular Endothelial Growth Factor Inhibitor [EPC]injection2023

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Regeneron
RegeneronTARRYTOWN, NY
9 programs
1
1
2
2
EyleaPhase 4
Intravitreal aflibercept injectionPhase 41 trial
AfliberceptPhase 3
ranibizumabPhase 3Monoclonal Antibody
VEGF Trap EyePhase 2
+4 more programs
Active Trials
NCT00320814Completed5Est. Aug 2007
NCT02689518Completed50Est. Nov 2019
Alcon
AlconFORT WORTH, TX
5 programs
1
4
Anecortave AcetatePhase 31 trial
Anecortave Acetate 15 mg sterile suspensionPhase 31 trial
Anecortave Acetate Sterile Suspension, 30 mg/mLPhase 31 trial
anecortave acetatePhase 31 trial
Anecortave Acetate Sterile SuspensionPhase 21 trial
Active Trials
NCT00211458CompletedEst. Sep 2007
NCT00065728TerminatedEst. Oct 2008
NCT00051129Completed291Est. May 2008
+2 more trials
Opko Health
Opko HealthMIAMI, FL
3 programs
1
1
1
bevasiranibPhase 3Small Molecule1 trial
BevasiranibPhase 2Small Molecule1 trial
bevasiranibPhase 1Small Molecule1 trial
Active Trials
NCT00722384CompletedEst. Dec 2007
NCT00259753CompletedEst. Dec 2007
NCT00499590TerminatedEst. May 2009
Bausch + Lomb
Bausch + LombNJ - Bridgewater
2 programs
1
1
AntioxidantsPhase 31 trial
Retisert ImplantPhase 21 trial
Active Trials
NCT00000145Completed4,757Est. Dec 2006
Genentech
GenentechCA - Oceanside
2 programs
1
1
rhuFab V2Phase 31 trial
ranibizumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT00896779Completed20Est. Sep 2013
NCT00061594Completed426Est. Sep 2006
UP
UCB PharmaBelgium - Brussels
1 program
1
AlprostadilPhase 31 trial
Active Trials
NCT00619229Terminated37Est. Feb 2010
Stada
StadaBosnia & Herzegovina - Banja Luka
1 program
1
RanibizumabPhase 3Monoclonal Antibody
Xbrane Biopharma
Xbrane BiopharmaSweden - Solna
1 program
1
RanibizumabPhase 3Monoclonal Antibody1 trial
Active Trials
NCT03805100CompletedEst. Nov 2021
Ionis Pharmaceuticals
1 program
1
IONIS-FB-LRxPhase 21 trial
Active Trials
NCT03815825Completed332Est. Jun 2024
Grifols
GrifolsNEW YORK, NY
1 program
1
Immune Globulin Intravenous [Human], 10% Caprylate/Chromatography PurifiedPhase 21 trial
Active Trials
NCT00220805CompletedEst. May 2005
Roche
RocheSTAVANGER NORWAY, Norway
2 programs
1
1
ZifibancimigPhase 1/21 trial
RO6867461Phase 11 trial
Active Trials
NCT01941082Completed24Est. Feb 2015
NCT04567303Active Not Recruiting177Est. Aug 2026
Bayer
BayerLEVERKUSEN, Germany
6 programs
1
VEGF TrapPhase 13 trials
AfliberceptN/A5 trials
AfliberceptN/A1 trial
EyleaN/A1 trial
EyleaN/A2 trials
+1 more programs
Active Trials
NCT07389980Recruiting50Est. Dec 2028
NCT07365371Not Yet Recruiting174Est. Dec 2027
NCT07129239Not Yet Recruiting180Est. Feb 2027
+12 more trials
Sanofi
SanofiPARIS, France
1 program
1
AAV2-sFLT01Phase 11 trial
Active Trials
NCT01024998Completed19Est. Jul 2018
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
BI 754132Phase 11 trial
Active Trials
NCT04002310Terminated18Est. Aug 2022
Pfizer
PfizerNEW YORK, NY
1 program
pegaptanib sodiumN/A5 trials
Active Trials
NCT01175070Completed30Est. Mar 2013
NCT00845273Completed3,538Est. Feb 2014
NCT01486771Unknown30Est. Feb 2014
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
BayerAflibercept
BayerAflibercept
BayerAflibercept
BayerAflibercept
BayerAflibercept
BayerAflibercept
BayerAflibercept
BayerAflibercept
BayerAflibercept
BayerAflibercept
BayerAflibercept
BayerAflibercept
RegeneronIntravitreal aflibercept injection
BayerAflibercept
BayerAflibercept

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 11,465 patients across 50 trials

NCT07365371BayerAflibercept

A Prospective, Multicenter, Open-label, Randomized Clinical Trial to Evaluate the Efficacy, Durability, and Safety of Aflibercept 8mg in Different Treatment Regimens in Chinese Patients With Polypoidal Choroidal Vasculopathy (PCV)

Start: Jan 2026Est. completion: Dec 2027174 patients
Phase 4Not Yet Recruiting
NCT06591598BayerAflibercept

A Study to Learn About the Blood Levels of Aflibercept When High-dose Aflibercept is Injected in Both Eyes of Participants With Diabetic Macular Edema or Neovascular Age-related Macular Degeneration

Start: Sep 2024Est. completion: Oct 202551 patients
Phase 4Completed
NCT05473715BayerAflibercept

A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment

Start: Apr 2023Est. completion: Jul 20233 patients
Phase 4Terminated
NCT05511038BayerAflibercept

A Study to Learn How Safe the Study Drug Intravitreal (Given by an Injection Into the Eye) Aflibercept is in Participants in India With Diabetic Macular Edema

Start: Aug 2022Est. completion: Apr 2024100 patients
Phase 4Completed
NCT03453281BayerAflibercept

Early Anatomical, Physiological, and Clinical Changes in Diabetic Macular Edema After Intravitreal Aflibercept Injection

Start: Oct 2017Est. completion: May 201836 patients
Phase 4Completed
NCT02924987BayerAflibercept

Effect of Aflibercept (Eylea®) in the Management of Bevacizumab (Avastin®) Resistant Diabetic Macular Edema

Start: Nov 2016Est. completion: Nov 201740 patients
Phase 4Unknown
NCT02633852BayerAflibercept

Multicenter Study to Evaluate the Efficacy of Treat and Extend Regimen of Aflibercept (EYLEA) as a Second Line Treatment for Diabetic Macular Edema

Start: May 2016Est. completion: Sep 201848 patients
Phase 4Completed
NCT03169660BayerAflibercept

Intravitreal Aflibercept for Submacular Hemorrhage

Start: Dec 2015Est. completion: Jan 201929 patients
Phase 4Completed
NCT02581891BayerAflibercept

Managing Neovascular (Known as "Wet") Age-related Macular Degeneration Over 2 Years Using Different Treatment Schedules of 2 mg Intravitreal Aflibercept Injected in the Eye

Start: Nov 2015Est. completion: Apr 2019287 patients
Phase 4Completed
NCT02581995BayerAflibercept

Investigation of the Change of Vision-related Quality of Life in Subjects Treated With Aflibercept According to EU Label for DME.

Start: Nov 2015Est. completion: Aug 2017560 patients
Phase 4Completed
NCT02305238BayerAflibercept

Japanese Treat and Extend Study of Aflibercept in Neovascular Age-related Macular Degeneration

Start: Dec 2014Est. completion: Dec 2017288 patients
Phase 4Completed
NCT02120950BayerAflibercept

Aflibercept in Polypoidal Choroidal Vasculopathy

Start: May 2014Est. completion: Jul 2017333 patients
Phase 4Completed
NCT02689518RegeneronIntravitreal aflibercept injection

EAGLE: Evaluating Genotypes Using Intravitreal Aflibercept Injection

Start: Apr 2014Est. completion: Nov 201950 patients
Phase 4Completed
NCT02072408BayerAflibercept

Efficacy and Safety of Intravitreal Vascular Endothelial Growth Factor Trap-eye in Patients With Polyploidal Choroidal Vasculopathy

Start: Feb 2014Est. completion: Nov 201746 patients
Phase 4Completed
NCT01918878BayerAflibercept

Aflibercept (EYLEA)as Secondary or Third Line Treatment for Neovascular Age-related Macular Degeneration.

Start: Oct 2013Est. completion: Apr 201648 patients
Phase 4Unknown
NCT01896284BayerAflibercept

Study to Evaluate Efficacy of Aflibercept in Neovascular Age-related Macular Degeneration Patients Non Responders to Anti-Vascular Endothelial Growth Factor

Start: Jul 2013Est. completion: Jun 201546 patients
Phase 4Completed
NCT01175070Pfizerpegaptanib sodium

Intravitreal Macugen for Ischaemic Diabetic Macular Oedema

Start: Jan 2011Est. completion: Mar 201330 patients
Phase 4Completed
NCT01486771Pfizerpegaptanib sodium

Macugen for Proliferative Diabetic Retinopathy Study With Extended Dosing (M-PDRS ED)

Start: Nov 2007Est. completion: Feb 201430 patients
Phase 4Unknown
NCT00324116Pfizerpegaptanib sodium

Evaluation Of Safety And Efficacy Of 0.3 Mg/Eye Macugen In Patients With Small Age-Related Macular Degeneration Lesions

Start: Jul 2006Est. completion: Aug 200881 patients
Phase 4Completed
NCT00312351Pfizerpegaptanib sodium

A Clinical Trial to Explore the Safety and Efficacy of Three Different Doses of Pegaptanib Sodium in Patients With Wet Age-Related Macular Degeneration (AMD)

Start: Apr 2006Est. completion: Nov 2006262 patients
Phase 4Terminated
NCT00406107Pfizerpegaptanib sodium

Evaluation of Macugen Treatment of Macular Edema Due to Branch Retinal Vein Occlusion

Start: Jan 2006Est. completion: Apr 200820 patients
Phase 4Completed
NCT00134667Pfizerpegaptanib sodium

Macugen (Pegaptanib Sodium) Alone, Versus Macugen in Combination With PDT (Photodynamic Therapy) With Visudyne (Verteporfin) in Patients With Age-Related Macular Degeneration (AMD)

Start: Mar 2005Est. completion: Oct 2008360 patients
Phase 4Terminated
NCT07389980BayerAflibercept

Prospective Trial of the Efficacy and Safety of a Personalized Regimen of High-dose Aflibercept 8mg on Treatment-naive Polypoidal Choroidal Vasculopathy: the PALLAS Trial

Start: Dec 2026Est. completion: Dec 202850 patients
Phase 3Recruiting
NCT07129239BayerAflibercept

High Dose (HD) Aflibercept Switch in Neovascular Age-related Macular Degeneration (nAMD): to Load or Maintain (HEIRLOOM)

Start: Aug 2025Est. completion: Feb 2027180 patients
Phase 3Not Yet Recruiting
NCT06422507BayerAflibercept

A Study to Learn More About How Well 8 Milligram Aflibercept Works and How Safe it is in Chinese Participants With Diabetic Macular Edema

Start: May 2024Est. completion: Mar 2026333 patients
Phase 3Active Not Recruiting
NCT05850520BayerAflibercept

A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)

Start: May 2023Est. completion: May 2025892 patients
Phase 3Completed
NCT04423718BayerAflibercept

Study of the Effects of High Dose Aflibercept Injected Into the Eye of Patients With an Age-related Disorder That Causes Loss of Vision Due to Growth of Abnormal Blood Vessels at the Back of the Eye

Start: Aug 2020Est. completion: Aug 20241,011 patients
Phase 3Completed
NCT04015180BayerAflibercept

Extension Study to Evaluate the Long-term Outcomes of Subjects in Study 20090

Start: Mar 2020Est. completion: Sep 2025100 patients
Phase 3Completed
NCT04004208BayerAflibercept

Aflibercept for Retinopathy of Prematurity - Intravitreal Injection Versus Laser Therapy

Start: Sep 2019Est. completion: Feb 2021113 patients
Phase 3Completed
NCT04113538BayerAflibercept

Treat and Extend Analysis Trial With Aflibercept in Wet-AMD

Start: Jul 2019Est. completion: May 202340 patients
Phase 3Unknown

Comparing the Efficacy and Safety of Biosimilar Candidate Xlucane Versus Lucentis® in Patients With nAMD

Start: Apr 2019Est. completion: Nov 2021
Phase 3Completed
NCT03639675BayerAflibercept

Study to Learn How the Drug Aflibercept Works in in Japanese Patients With Increased Eye Pressure That is Caused by New Blood Vessels Growing in the Eye (Neovascular Glaucoma or NVG). Safety of the Drug and Patients' Tolerability of the Drug Injection is Also Studied

Start: Oct 2018Est. completion: Mar 201916 patients
Phase 3Completed
NCT02818998BayerAflibercept

Efficacy and Safety of Three Different Aflibercept Regimens in Subjects With Diabetic Macular Edema (DME)

Start: Nov 2016Est. completion: Sep 2019463 patients
Phase 3Completed
NCT02540954BayerAflibercept

Efficacy and Safety of Two Different Aflibercept Regimens in Subjects With Neovascular Age-related Macular Degeneration (nAMD)

Start: Sep 2015Est. completion: Jun 2020336 patients
Phase 3Completed
NCT02396316BayerAflibercept

Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients

Start: Apr 2015Est. completion: Sep 201654 patients
Phase 3Completed
NCT02157077BayerAflibercept

Aflibercept After Ranibizumab in Exudative Age-related Macular Degeneration

Start: Dec 2013Est. completion: Dec 201590 patients
Phase 3Completed
NCT01783886BayerAflibercept

Efficacy and Safety of VEGF Trap Eye in Diabetic Macular Edema (DME) With Central Involvement

Start: Feb 2013Est. completion: Mar 2015381 patients
Phase 3Completed
NCT01521559BayerAflibercept

Study to Assess the Clinical Efficacy and Safety of Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321) in Patients With Branch Retinal Vein Occlusion (BRVO)

Start: Apr 2012Est. completion: Mar 2014183 patients
Phase 3Completed

Japanese Safety Study of VEGF Trap-Eye in DME (Diabetic Macular Edema)

Start: Jan 2012Est. completion: Sep 201373 patients
Phase 3Completed
NCT01482910BayerAflibercept

VEGF Trap-Eye: Investigation of Efficacy and Safety in Chinese Subjects With Wet AMD (Age-Related Macular Degeneration)

Start: Dec 2011Est. completion: Aug 2014304 patients
Phase 3Completed
NCT01331681BayerAflibercept

Intravitreal Aflibercept Injection in Vision Impairment Due to DME

Start: May 2011Est. completion: Mar 2015406 patients
Phase 3Completed
NCT01363440BayerAflibercept

Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Patients With Diabetic Macular Edema

Start: May 2011Est. completion: Nov 2014466 patients
Phase 3Completed
NCT01012973BayerAflibercept

Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)

Start: Oct 2009Est. completion: Feb 2012177 patients
Phase 3Completed
NCT00637377BayerAflibercept

Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD)

Start: Apr 2008Est. completion: Aug 20111,240 patients
Phase 3Completed

Safety & Efficacy Study Evaluating the Combination of Bevasiranib & Lucentis Therapy in Wet AMD

Start: Aug 2007Est. completion: May 2009
Phase 3Terminated
NCT00509795BayerAflibercept

Vascular Endothelial Growth Factor VEGF Trap-Eye:Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration(AMD)

Start: Aug 2007Est. completion: Jul 20111,217 patients
Phase 3Completed
NCT00051129AlconAnecortave Acetate 15 mg sterile suspension

Anecortave Acetate in Subfoveal Choroidal Neovascularization (CNV) Due to Wet Age-Related Macular Degeneration (AMD)

Start: Jan 2007Est. completion: May 2008291 patients
Phase 3Completed

Alprostadil in Maculopathy Study (AIMS)

Start: Jul 2006Est. completion: Feb 201037 patients
Phase 3Terminated
NCT00299507AlconAnecortave Acetate Sterile Suspension, 30 mg/mL

Anecortave Acetate in Patients With Exudative Age-related Macular Degeneration (AMD)

Start: Mar 2005Est. completion: Apr 2008
Phase 3Completed
NCT00150202Pfizerpegaptanib sodium

Clinical Study Of EYE001 For Wet-Type AMD (Age-Related Macular Degeneration)

Start: Jul 2004Est. completion: Oct 200690 patients
Phase 3Completed

Related Jobs in Ophthalmology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 11,465 patients
15 companies competing in this space