Cataract

Ophthalmology
53
Pipeline Programs
16
Companies
50
Clinical Trials
4 recruiting
9
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
2
0
20
28
Early DiscoveryClinical DevelopmentMarket

On Market (9)

Approved therapies currently available

Bausch + Lomb
ALREXApproved
loteprednol etabonate
Bausch + Lomb
ophthalmic1998
U
BYQLOVIApproved
clobetasol propionate
Unknown Company
ophthalmic2024
U
CLOBETASOL PROPIONATEApproved
clobetasol propionate
Unknown Company
topical2005
U
IMPEKLOApproved
clobetasol propionate
Unknown Company
topical2020
U
IMPOYZApproved
clobetasol propionate
Unknown Company
topical2017
Bausch + Lomb
LOTEMAXApproved
loteprednol etabonate
Bausch + Lomb
ophthalmic2012
Bausch + Lomb
LOTEMAX SMApproved
loteprednol etabonate
Bausch + Lomb
ophthalmic2019
U
OLUXApproved
clobetasol propionate
Unknown Company
topical2000
U
OLUX EApproved
clobetasol propionate
Unknown Company
topical2007

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Alcon
AlconFORT WORTH, TX
42 programs
5
10
AcrySof ReSTOR Aspheric IOL model SN6AD1Phase 41 trial
AcrySof ReSTOR Aspheric IOL models SN6AD1 and SN6AD3Phase 41 trial
AcrySof Toric IOLPhase 41 trial
AcrySof® IQ IOLPhase 41 trial
DisCoViscPhase 41 trial
+37 more programs
Active Trials
NCT00758576Completed64Est. Dec 2009
NCT03010254CompletedEst. Oct 2018
NCT03350503Completed125Est. Dec 2021
+39 more trials
Bausch + Lomb
Bausch + LombNJ - Bridgewater
33 programs
2
8
7
Advanced Akreos Adapt in one operated eye.Phase 41 trial
Akreos Toric IOLPhase 41 trial
Crystalens AOPhase 41 trial
Crystalens AOPhase 41 trial
Crystalens AOPhase 41 trial
+28 more programs
Active Trials
NCT00804726Terminated10Est. Jul 2010
NCT03511638Completed372Est. Apr 2019
NCT04192630Completed390Est. Jan 2022
+30 more trials
Abbott
AbbottABBOTT PARK, IL
15 programs
1
2
1
Tecnis Multifocal IOLPhase 42 trials
Standard Monofocal Intraocular LensPhase 31 trial
modified light transmission intraocular lensPhase 31 trial
Tecnis Multifocal Intraocular LensPhase 13 trials
Administration of patient self-assessmentN/A2 trials
+10 more programs
Active Trials
NCT02203747Completed79Est. Jan 2015
NCT02146599Completed301Est. Jul 2014
NCT02782676Completed241Est. May 2017
+16 more trials
S
SantenCA - Emeryville
2 programs
1
1
1.5% levofloxacin ophthalmic solutionPhase 41 trial
MD-15 Intraocular LensPhase 31 trial
Active Trials
NCT02888210Completed110Est. Nov 2017
NCT00630019Completed96
Salvat
SalvatFL - Miami
2 programs
2
Clobetasol PropionatePhase 31 trial
Clobetasol propionatePhase 31 trial
Active Trials
NCT04249076CompletedEst. Apr 2021
NCT04246801CompletedEst. May 2021
Sintetica
SinteticaSwitzerland - Mendriosi
1 program
1
Chloroprocaine 3%Phase 31 trial
Active Trials
NCT04685538Completed338Est. Mar 2021
Thea Pharma
Thea PharmaMA - Waltham
1 program
1
T2380Phase 31 trial
Active Trials
NCT02101359CompletedEst. May 2013
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
1
Hypnoanalgesia; Hypnotic shieldingPhase 1/21 trial
Active Trials
NCT00176098Unknown70
Emmecell
EmmecellCA - Menlo Park
1 program
1
EO2002Phase 11 trial
Active Trials
NCT05587205Recruiting32Est. Oct 2026
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
3 programs
TECNIS® TORIC II Intraocular LensN/A1 trial
Tecnis Symfony Optiblue/Tecnis Symfony Optiblue ToricN/A1 trial
VERITAS Vision SystemN/A1 trial
Active Trials
NCT04210232Completed54Est. Sep 2020
NCT06567834Completed60Est. Mar 2023
NCT04332640Completed79Est. May 2021
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
2 programs
EYEFILL® C.-US ViscoelasticN/A
Trulign™ Toric IOLN/A
Verona Pharma
Verona PharmaUK - London
2 programs
Extended Depth of Focus Intraocular Lens ImplantationN/A1 trial
Fusion EDOF IOL ImplantationN/A1 trial
Active Trials
NCT07338708Completed10Est. May 2025
NCT07295119Completed36Est. Nov 2024
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
'Off the shelf' toric lensN/A1 trial
Active Trials
NCT04122651UnknownEst. Aug 2020
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
OCT Scan, Video of pupil movement, video of toric lensN/A1 trial
Active Trials
NCT06160960UnknownEst. Oct 2024
RxSight
RxSightALISO VIEJO, CA
1 program
RxSight RxLALN/A1 trial
Active Trials
NCT03771352Completed55Est. Jul 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
AlconMoxifloxacin 0.5%/Dexamethasone 0.1% ophthalmic solution
AbbottTecnis Multifocal IOL
Bausch + LombCrystalens AO
Bausch + LombCrystalens AO
AlconReSTOR +3
Bausch + LombCrystalens AO
AbbottTecnis Multifocal Intraocular Lens
AlconAcrySof ReSTOR Aspheric IOL models SN6AD1 and SN6AD3
Bausch + LombAkreos Toric IOL
AlconAcrySof ReSTOR Aspheric IOL model SN6AD1
AlconVigadexa
AlconAcrySof® IQ IOL
AlconDisCoVisc®
Bausch + LombIndomethacin ophthalmic solution
Santen1.5% levofloxacin ophthalmic solution

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 8,774 patients across 50 trials

NCT01859702AlconMoxifloxacin 0.5%/Dexamethasone 0.1% ophthalmic solution

Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients

Start: Apr 2012Est. completion: Aug 201236 patients
Phase 4Completed
NCT01275118AbbottTecnis Multifocal IOL

Comparison of Postoperative Visual Acuity and Spectacle Independence Between the Tecnis Multifocal Intraoculer Lens (IOL) and the Crystalens Accommodating IOL

Start: Dec 2010Est. completion: Sep 201126 patients
Phase 4Completed
NCT01241279Bausch + LombCrystalens AO

Accommodation Measurements After Bilateral Implantation of an Aspheric Accommodating Lens and Monofocal Aspheric Lenses

Start: Oct 2010Est. completion: Dec 20116 patients
Phase 4Terminated
NCT01225952Bausch + LombCrystalens AO

Three Intraocular Lenses Designed to Improve Distance, Intermediate and Near Vision Following Lens Extraction

Start: Jul 2010Est. completion: Jul 201193 patients
Phase 4Completed
NCT01166971AlconReSTOR +3

A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs)

Start: Jul 2010
Phase 4Completed
NCT01122576Bausch + LombCrystalens AO

Evaluation of 3 Intraocular Lenses Following Lens Extraction

Start: Jun 2010Est. completion: Sep 201278 patients
Phase 4Completed
NCT01210807AbbottTecnis Multifocal Intraocular Lens

Clinical Evaluation of the One-Piece Tecnis Multifocal Intraocular Lens (IOL)

Start: Nov 2009Est. completion: Aug 201170 patients
Phase 4Completed
NCT00710905AlconAcrySof ReSTOR Aspheric IOL models SN6AD1 and SN6AD3

Visual Function With Contralateral AcrySof® ReSTOR® Aspheric SN6AD1 and SN6AD3

Start: Oct 2009Est. completion: Sep 2010
Phase 4Terminated
NCT00825513Bausch + LombAkreos Toric IOL

Safety and Effectiveness of the Akreos Toric Intraocular Lens.

Start: Feb 2009Est. completion: Sep 2012198 patients
Phase 4Completed
NCT00710931AlconAcrySof ReSTOR Aspheric IOL model SN6AD1

Visual Function With Bilateral AcrySof® ReSTOR® Aspheric SN6AD1

Start: Oct 2008Est. completion: Sep 201035 patients
Phase 4Completed
NCT00870103AlconVigadexa

Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery

Start: Sep 2008
Phase 4Completed
NCT00760058AlconAcrySof® IQ IOL

Visual Outcome and Visual Quality After Bilateral Implantation of the AcrySof® IQ IOL Compared to MI60® and Tecnis® IOL

Start: Jun 2008Est. completion: Dec 20100
Phase 4Withdrawn
NCT00763360AlconDisCoVisc®

To Compare the Ability of DiscoVisc® OVD to Protect the Corneal Endothelium and Maintain Anterior Chamber Space With Healon® and Amvisc® PLUS During Cataract Surgery.

Start: May 2008
Phase 4Completed
NCT00904904Bausch + LombIndomethacin ophthalmic solution

Indomethacin Eyedrops Compared With Ketorolac Eyedrops for Ocular Inflammation Following Cataract Surgery

Start: Apr 2008Est. completion: Sep 2009120 patients
Phase 4Completed
NCT00630019Santen1.5% levofloxacin ophthalmic solution

Ocular Tissue Levels of 1.5% Levofloxacin Ophthalmic Solution Compared to an Active Comparator

Start: Feb 200896 patients
Phase 4Completed
NCT00712244AlconDisCoVisc

DisCoVisc Versus DuoVisc, Healon5 and AmVisc Plus

Start: Oct 2007112 patients
Phase 4Completed
NCT00721253AlconReSTOR

Visual Outcomes of Subjects Bilaterally Implanted With ReSTOR Aspheric +4 vs. Tecnis or Acri.LISA

Start: Jul 2007Est. completion: Oct 200842 patients
Phase 4Completed
NCT00760487AlconAcrySof Toric IOL

Visual Function After Implantation of Bilateral AcrySof® Toric Natural Intraocular Lens

Start: Oct 2006
Phase 4Completed
NCT00838045Bausch + LombThe Bausch & Lomb Akreos TL IOL

Evaluation of the Safety & Effectiveness of the Bausch & Lomb AKREOS® TL Intraocular Lens

Start: Sep 2006Est. completion: Sep 2008125 patients
Phase 4Completed
NCT00786565Bausch + LombAdvanced Akreos Adapt in one operated eye.

Clinical Evaluation of a New Aspheric Intraocular Lens.

Start: Jan 2004Est. completion: Jan 200875 patients
Phase 4Completed
NCT04685538SinteticaChloroprocaine 3%

Chloroprocaine 3% Gel Eye Drop as Topical Anestheticsin Phacoemulsification.

Start: Sep 2020Est. completion: Mar 2021338 patients
Phase 3Completed
NCT04246801SalvatClobetasol propionate

Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-1)

Start: Jun 2020Est. completion: May 2021
Phase 3Completed
NCT04249076SalvatClobetasol Propionate

Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-2)

Start: Jun 2020Est. completion: Apr 2021
Phase 3Completed
NCT02888210SantenMD-15 Intraocular Lens

A Study Assessing Safety and Efficacy of MD-15 Intraocular Lens in Patients With Aphakic Eye After Cataract Surgery

Start: Sep 2016Est. completion: Nov 2017110 patients
Phase 3Completed
NCT02786901Bausch + LombLoteprednol Etabonate Ophthalmic Gel dosed TID

LE Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

Start: Jun 2016Est. completion: Jul 2017600 patients
Phase 3Completed
NCT01475643Bausch + LombLoteprednol etabonate

Loteprednol vs Prednisolone for the Treatment of Intraocular Inflammation Following Cataract Surgery in Children.

Start: Jun 2013Est. completion: Jul 2017107 patients
Phase 3Completed
NCT01591655Bausch + LombMapracorat

Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

Start: Jul 2012Est. completion: Oct 2013360 patients
Phase 3Completed
NCT01591161Bausch + LombMapracorat

Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

Start: Jul 2012Est. completion: Jul 2013369 patients
Phase 3Completed
NCT01426854AlconNepafenac Ophthalmic Suspension, 0.1%

Nepafenac Compared to Placebo for Ocular Pain and Inflammation

Start: Jul 2011Est. completion: Apr 2012260 patients
Phase 3Completed
NCT02101359Thea PharmaT2380

Efficacy and Safety Assessment of Intracameral Injection of T2380 in Cataract Surgery

Start: Jun 2011Est. completion: May 2013
Phase 3Completed
NCT01230125Bausch + LombMapracorat

Mapracorat Ophthalmic Suspension for the Treatment of Ocular Inflammation Following Cataract Surgery

Start: Nov 2010Est. completion: Aug 2011311 patients
Phase 3Completed
NCT01109173AlconNepafenac Ophthalmic Suspension, 0.3%

Confirmatory Study Nepafenac 0.3%

Start: Jun 20102,120 patients
Phase 3Completed
NCT00854061Bausch + LombT-Pred

Study of T-PRED(TM) Compared to Pred Forte(R) II

Start: Feb 2009Est. completion: Aug 2009172 patients
Phase 3Completed
NCT00704418Bausch + LombBromfenac

Efficacy and Safety of Bromfenac Ophthalmic Solution in Cataract Surgery

Start: Jun 2008Est. completion: Dec 2009156 patients
Phase 3Completed
NCT00703781Bausch + Lombbromfenac ophthalmic solution

Efficacy and Safety of Bromfenac Ophthalmic Solution in Cataract Surgery

Start: Jun 2008126 patients
Phase 3Completed
NCT00747227Abbottmodified light transmission intraocular lens

Safety and Efficacy of a Violet Visible Light Blocking Intraocular Lens (IOL)

Start: Dec 2006Est. completion: Jun 2009250 patients
Phase 3Completed
NCT00346528AlconNext Generation Ophthalmic Irrigating Solution

Safety of NGOIS Compared to BSS Plus in Pediatric Patients

Start: Jul 2006Est. completion: Jun 200718 patients
Phase 3Completed
NCT00362895AlconTobramycin 0.3% / Dexamethasone 0.033% ophthalmic suspension

A Bioequivalence Study of Tobradex AF

Start: Apr 2006Est. completion: Aug 2006
Phase 3Completed
NCT00425464AbbottStandard Monofocal Intraocular Lens

A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the Synchrony Dual Optic Intraocular Lens in Patients Undergoing Cataract Extraction

Start: Nov 2005Est. completion: Apr 2013410 patients
Phase 3Terminated
NCT00333268AlconNext Generation Ophthalmic Irrigating Solution

Safety and Efficacy of Next Generation Ophthalmic Irrigating Solution Compared to BSS Plus

Start: Sep 2004Est. completion: Jul 2005369 patients
Phase 3Completed
NCT00905450Bausch + LombBOL-303242-X

Evaluation of BOL-303242-X Versus Vehicle for the Treatment of Inflammation Following Cataract Surgery

Start: Jun 2009Est. completion: May 2010415 patients
Phase 2Completed
NCT00699803Bausch + LombT-PRED

Study of T-PRED(TM) Compared to Pred Forte(R)

Start: May 2008Est. completion: Aug 200864 patients
Phase 2Completed
NCT00176098Heidelberg PharmaHypnoanalgesia; Hypnotic shielding

Hypnosis for Eye Surgery

Start: Sep 200570 patients
Phase 1/2Unknown
NCT05587205EmmecellEO2002

Safety and Tolerability of EO2002

Start: Aug 2022Est. completion: Oct 202632 patients
Phase 1Recruiting
NCT01714635AbbottTecnis Multifocal Intraocular Lens

Clinical Investigation of Expanded Designs of a Multifocal IOL

Start: Nov 2012Est. completion: Jul 2014445 patients
Phase 1Completed
NCT07044674AlconUNITY Vitreoretinal Cataract System

A Cataract Surgery Clinical Trial

Start: Feb 2026Est. completion: Jun 20260
N/AWithdrawn
NCT06987474AlconUnity DX and SMARTCataract DX

Capella Scientia Development Study

Start: Jul 2025Est. completion: Mar 2028400 patients
N/ARecruiting
NCT06801678AlconRefractive Outcomes Utilizing Two SS-OCT Biometers for IOL Power Calculations

Refractive Outcomes Utilizing Two SS-OCT Biometers for IOL Power Calculations

Start: Jan 2025Est. completion: Feb 2025
N/ARecruiting
NCT06767917Bausch + LombEyefill® S.C.

A Post-Market Clinical Follow-Up on Safety and Performance of the Ophthalmic Viscoelastic Devices Eyefill SC and Eyefill MB

Start: Nov 2024Est. completion: Jan 2026150 patients
N/ARecruiting
NCT07338708Verona PharmaExtended Depth of Focus Intraocular Lens Implantation

Visual Outcomes and Quality of Life After Vivity EDOF IOL Implantation in Early-Stage Keratoconus

Start: Sep 2024Est. completion: May 202510 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

20 late-stage (Phase 3) programs — potential near-term approvals
4 actively recruiting trials targeting 8,774 patients
16 companies competing in this space

Related Indications

Myopia(127)Open-Angle Glaucoma(102)Glaucoma(92)Dry Eye(74)Age-Related Macular Degeneration(73)Dry Eye Disease(43)Neovascular Age-related Macular Degeneration(40)Macular Degeneration(37)Diabetic Retinopathy(25)Cataracts(22)