Liver Fibrosis

Gastroenterology
3
Pipeline Programs
4
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
2
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
2100%
+ 3 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

GS
Gilead SciencesFOSTER CITY, CA
2 programs
2
SimtuzumabPhase 2Monoclonal Antibody1 trial
SimtuzumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT01707472Completed18Est. Oct 2014
NCT01452308Completed20Est. Aug 2013
M&
Merck & Co.RAHWAY, NJ
1 program
1
MREPhase 11 trial
Active Trials
NCT00896233Completed10Est. Jan 2010
FUJIFILM Pharma
FUJIFILM PharmaMA - Cambridge
1 program
Endosonographic ElastographyN/A
Providence Therapeutics
1 program
Endosonographic ElastographyN/A1 trial
Active Trials
NCT06867731Enrolling By InvitationEst. Jan 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Gilead SciencesSimtuzumab
Gilead SciencesSimtuzumab
Merck & Co.MRE
Providence TherapeuticsEndosonographic Elastography

Clinical Trials (4)

Total enrollment: 48 patients across 4 trials

NCT01707472Gilead SciencesSimtuzumab

Study of Simtuzumab in HIV and/or Hepatitis C- Infected Adults With Liver Fibrosis

Start: Oct 2012Est. completion: Oct 201418 patients
Phase 2Completed
NCT01452308Gilead SciencesSimtuzumab

Pilot Study of Simtuzumab in the Treatment of Liver Fibrosis

Start: Nov 2011Est. completion: Aug 201320 patients
Phase 2Completed
NCT00896233Merck & Co.MRE

Magnetic Resonance Elastography for Assessment of Liver Fibrosis (MK-0000-132)(COMPLETED)

Start: Aug 2009Est. completion: Jan 201010 patients
Phase 1Completed
NCT06867731Providence TherapeuticsEndosonographic Elastography

Endosonographic Shear Wave Elastography to Assess Liver and Splenic Fibrosis

Start: Jan 2025Est. completion: Jan 2027
N/AEnrolling By Invitation

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 companies competing in this space

Related Indications

Hepatic Impairment(79)Gastroesophageal Reflux Disease(37)Irritable Bowel Syndrome(29)Gastroesophageal Reflux(27)Liver Transplantation(24)Celiac Disease(23)Hepatic Insufficiency(22)Liver Cirrhosis(22)Gastroesophageal Reflux Disease (GERD)(14)Hepatic Encephalopathy(12)