Hepatic Insufficiency

Gastroenterology
22
Pipeline Programs
9
Companies
23
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
22
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
8100%
+ 14 programs with unclassified modality

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
10 programs
10
BI 1015550Phase 11 trial
BI 10773Phase 11 trial
BI 1356Phase 11 trial
BI 1584862Phase 11 trial
BI 425809Phase 11 trial
+5 more programs
Active Trials
NCT05661344Completed28Est. Sep 2023
NCT01111318Completed36
NCT02183376Completed33
+7 more trials
M&
Merck & Co.RAHWAY, NJ
4 programs
4
BomedemstatPhase 1Small Molecule1 trial
ElbasvirPhase 1Small Molecule1 trial
MK-3866Phase 11 trial
UlonivirinePhase 11 trial
Active Trials
NCT07049939Completed9Est. Feb 2026
NCT01797536Completed31Est. Aug 2014
NCT03295266Terminated9Est. Mar 2018
+1 more trials
Bristol Myers Squibb
2 programs
2
BMS-650032Phase 11 trial
OnuregPhase 11 trial
Active Trials
NCT01019070Completed28Est. Aug 2011
NCT05209295Terminated2Est. Apr 2025
Debiopharm
DebiopharmSwitzerland - Lausanne
1 program
1
AlisporivirPhase 1Small Molecule1 trial
Active Trials
NCT01860326CompletedEst. Sep 2011
Pfizer
PfizerNEW YORK, NY
1 program
1
CP-690,550Phase 11 trial
Active Trials
NCT00969813Completed18Est. Jan 2010
Genentech
GenentechCA - Oceanside
1 program
1
IpatasertibPhase 1Small Molecule1 trial
Active Trials
NCT03341884Completed29Est. Jun 2018
X4 Pharmaceuticals
1 program
1
MavorixaforPhase 11 trial
Active Trials
NCT06858696RecruitingEst. Apr 2026
Novartis
NovartisBASEL, Switzerland
1 program
1
QAB149Phase 12 trials
Active Trials
NCT00416702Completed32Est. Mar 2008
NCT00129831Completed6Est. Sep 2005
VP
1 program
1
telaprevirPhase 1Small Molecule1 trial
Active Trials
NCT00509210CompletedEst. Jun 2008

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
NovartisQAB149
Merck & Co.Ulonivirine
Merck & Co.Bomedemstat
Boehringer IngelheimBI 1584862
X4 PharmaceuticalsMavorixafor
Bristol Myers SquibbOnureg
Boehringer IngelheimBI 425809
Boehringer IngelheimBI 1015550
Merck & Co.MK-3866
GenentechIpatasertib
Boehringer IngelheimNintedanib
Merck & Co.Elbasvir
DebiopharmAlisporivir
Boehringer IngelheimBI 10773
Bristol Myers SquibbBMS-650032

Showing 15 of 23 trials with date data

Clinical Trials (23)

Total enrollment: 504 patients across 23 trials

Study to Assess the Safety and Tolerability of Incremental Doses of QAB149 in Adults With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD)

Start: Sep 2004Est. completion: Sep 20056 patients
Phase 2Completed

Ulonivirine (MK-8507) in Participants With Mild or Moderate Hepatic Impairment (MK-8507-014)

Start: Apr 2026Est. completion: Sep 202622 patients
Phase 1Not Yet Recruiting

A Study of Bomedemstat (MK-3543) in Participants With Mild or Moderate Hepatic Impairment (MK-3543-023)

Start: Aug 2025Est. completion: Feb 20269 patients
Phase 1Completed

A Study to Test How BI 1584862 is Taken up in the Blood of People With and Without Liver Problems

Start: Aug 2025Est. completion: Jun 202644 patients
Phase 1Recruiting

A Study to Investigate Pharmacokinetics (PK) and Safety of a Single Dose of Mavorixafor in Participants With Hepatic Impairment (HI) Compared to Matched Healthy Volunteers With Normal Hepatic Function

Start: Feb 2025Est. completion: Apr 2026
Phase 1Recruiting

A Study to Evaluate CC-486/Onureg in Participants With Moderate or Severe Hepatic Impairment Compared With Normal Hepatic Function in Participants With Myeloid Malignancies

Start: Jul 2024Est. completion: Apr 20252 patients
Phase 1Terminated

A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Liver Problems

Start: Mar 2023Est. completion: Dec 202328 patients
Phase 1Completed

A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problems

Start: Feb 2023Est. completion: Sep 202328 patients
Phase 1Completed

Single-Dose Pharmacokinetics of MK-3866 in Participants With Hepatic Impairment (MK-3866-006)

Start: Dec 2017Est. completion: Mar 20189 patients
Phase 1Terminated

A Study of Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants

Start: Nov 2017Est. completion: Jun 201829 patients
Phase 1Completed

Nintedanib in Volunteers With Hepatic Impairment Compared With Healthy Volunteers

Start: Jul 2014Est. completion: Jan 201533 patients
Phase 1Completed

The Influence of Hepatic Insufficiency on the Pharmacokinetics of Elbasvir (MK-8742) (MK-8742-009)

Start: Mar 2013Est. completion: Aug 201431 patients
Phase 1Completed

Evaluate the Pharmacokinetics, Safety, and Tolerability of Alisporivir in Subjects With Hepatic Impairment Compared to Healthy Subjects

Start: Mar 2011Est. completion: Sep 2011
Phase 1Completed

Pharmacokinetics of Empagliflozin (BI 10773) in Patients With Impaired Liver Function

Start: Jul 201036 patients
Phase 1Completed

Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032

Start: Dec 2009Est. completion: Aug 201128 patients
Phase 1Completed

A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function

Start: Nov 2009Est. completion: Jan 201018 patients
Phase 1Completed

Pharmacokinetics and Pharmacodynamics of BI 1356 in Subjects With Different Degrees of Liver Impairment as Compared to Healthy Subjects

Start: Jul 200833 patients
Phase 1Completed

Study of Telaprevir in Subjects With Hepatic Impairment

Start: Sep 2007Est. completion: Jun 2008
Phase 1Completed

Safety and Pharmacokinetics of Indacaterol in Healthy Subjects and Those With Impaired Liver Function

Start: Nov 2006Est. completion: Mar 200832 patients
Phase 1Completed

Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic Impairment

Start: Jan 200636 patients
Phase 1Completed

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Start: Jul 200524 patients
Phase 1Completed

Study to Determine the Pharmacokinetics on TPV/r in Subjects With Mild and Moderate Hepatic Insufficiency

Start: Oct 200324 patients
Phase 1Completed

Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Patients With Hepatic Impairment in Comparison to Healthy Volunteers

Start: Mar 200032 patients
Phase 1Completed

Related Jobs in Gastroenterology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 actively recruiting trials targeting 504 patients
9 companies competing in this space