Cirrhosis

Gastroenterology
7
Pipeline Programs
7
Companies
9
Clinical Trials
4 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
5
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Grifols
GrifolsNEW YORK, NY
4 programs
3
1
AlbuminPhase 41 trial
25% IV albuminPhase 21 trial
Albumin InfusionPhase 21 trial
Albumin infusionPhase 21 trial
Active Trials
NCT03585257CompletedEst. Mar 2022
NCT06052176RecruitingEst. Oct 2026
NCT06812390RecruitingEst. Mar 2027
+1 more trials
Bristol Myers Squibb
1 program
1
DUALPhase 21 trial
Active Trials
NCT01888900Completed35Est. Nov 2015
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
Empagliflozin 10 MGPhase 21 trial
Active Trials
NCT05726032Recruiting20Est. Jun 2026
M&
Merck & Co.RAHWAY, NJ
1 program
1
ARQ 197Phase 11 trial
Active Trials
NCT00802555Completed21Est. Dec 2011
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Complete blood countN/A1 trial
Active Trials
NCT05538546UnknownEst. Dec 2023
Bausch + Lomb
Bausch + LombNJ - Bridgewater
1 program
Dental exam and periodontal cleaning if neededN/A1 trial
Active Trials
NCT06052150Recruiting100Est. Dec 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
GrifolsAlbumin
GrifolsAlbumin infusion
GrifolsAlbumin Infusion
Boehringer IngelheimEmpagliflozin 10 MG
Grifols25% IV albumin
Bristol Myers SquibbDUAL
Merck & Co.ARQ 197
Bausch + LombDental exam and periodontal cleaning if needed
City TherapeuticsComplete blood count

Clinical Trials (9)

Total enrollment: 176 patients across 9 trials

NCT00968695GrifolsAlbumin

Effects of Long Term Albumin 20% Administration in Patients With Cirrhosis and Ascites.

Start: Jul 2009Est. completion: Apr 2014
Phase 4Completed
NCT06812390GrifolsAlbumin infusion

Albumin Assisted Diuresis in Patients with Cirrhosis and Ascites

Start: Feb 2025Est. completion: Mar 2027
Phase 2Recruiting
NCT06052176GrifolsAlbumin Infusion

Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement

Start: Nov 2023Est. completion: Oct 2026
Phase 2Recruiting
NCT05726032Boehringer IngelheimEmpagliflozin 10 MG

Empagliflozin in Patients With Cirrhosis and Ascites

Start: Sep 2023Est. completion: Jun 202620 patients
Phase 2Recruiting
NCT03585257Grifols25% IV albumin

HEAL STUDY (Hepatic Encephalopathy and Albumin Study)

Start: Jun 2018Est. completion: Mar 2022
Phase 2Completed
NCT01888900Bristol Myers SquibbDUAL

New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C

Start: May 2013Est. completion: Nov 201535 patients
Phase 2Completed
NCT00802555Merck & Co.ARQ 197

Safety Study of ARQ 197 in Cirrhotic Patients With Hepatocellular Carcinoma (HCC)

Start: Jan 2009Est. completion: Dec 201121 patients
Phase 1Completed
NCT06052150Bausch + LombDental exam and periodontal cleaning if needed

Oral Health In Cirrhosis of the Liver (ORACLE)

Start: Sep 2023Est. completion: Dec 2025100 patients
N/ARecruiting
NCT05538546City TherapeuticsComplete blood count

Baveno VI Criteria in Dynamic Monitoring of High-risk Varices in Compensated Cirrhotic Patients

Start: Sep 2022Est. completion: Dec 2023
N/AUnknown

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 actively recruiting trials targeting 176 patients
7 companies competing in this space

Related Indications

Hepatic Impairment(79)Gastroesophageal Reflux Disease(37)Irritable Bowel Syndrome(29)Gastroesophageal Reflux(27)Liver Transplantation(24)Celiac Disease(23)Hepatic Insufficiency(22)Liver Cirrhosis(22)Gastroesophageal Reflux Disease (GERD)(14)Hepatic Encephalopathy(12)