NDAORALTABLET, EXTENDED RELEASEPriority Review
Approved
Aug 2019
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
20
Data completeness
5/8 — Partial
Priority Review
RINVOQ (upadacitinib) by AbbVie is janus kinase inhibitors [moa]. First approved in 2019.
Drug data last refreshed 11h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
RINVOQ (upadacitinib) is an oral Janus Kinase (JAK) inhibitor approved in 2019 for rheumatoid arthritis and other inflammatory conditions. It works by selectively inhibiting JAK enzymes to reduce inflammatory cytokine signaling. The extended-release formulation enables once-daily dosing for improved patient adherence.
$0.976BPart D
Peak11.7 years to LOERINVOQ is at peak market penetration in a large and growing JAK inhibitor category, suggesting stable commercial team size with focus on market defense rather than rapid expansion.
Mechanism of Action
Janus Kinase Inhibitors
Pharmacologic Class:
Janus Kinase Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Upadacitinib in Patients Hospitalized With Acute Severe Ulcerative Colitis
Started Jul 2026
50 enrolled
UC - Ulcerative Colitis
A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis
Started Jul 2026
52 enrolled
EoEEosinophilic EsophagitisEosinophilic Esophagitis (EoE)
A Phase 1 Study of the Safety and How the Body Processes ABBV-722 and Upadacitinib After Multiple Oral Doses in Healthy Adult Participants
Started Feb 2026
32 enrolled
Healthy Volunteer
Upadacitinib Combined With Corticosteroids vs Corticosteroid Monotherapy Induction for Inpatients and Outpatients With Acute Severe Ulcerative Colitis
Started Jan 2026
110 enrolled
Ulcerative Colitis Acute
A Study to Assess the Effectiveness of Second-Line Therapy of Upadacitinib and Risankizumab in Adult Participants With Crohn's Disease in a Real-World Setting
Started Jul 2025
250 enrolled
Crohn's Disease
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.