Irritable Bowel Syndrome With Constipation

Gastroenterology
11
Pipeline Programs
4
Companies
8
Clinical Trials
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
4
0
4
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
4100%
+ 6 programs with unclassified modality

On Market (2)

Approved therapies currently available

U
AMITIZAApproved
lubiprostone
Unknown Company
Chloride Channel Activator [EPC]oral2006
U
LUBIPROSTONEApproved
lubiprostone
Unknown Company
Chloride Channel Activator [EPC]oral2023

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Ironwood Pharmaceuticals
8 programs
3
3
1
LinaclotidePhase 4Peptide1 trial
Irritable Bowel Syndrome with ConstipationPhase 3
LinaclotidePhase 3Peptide1 trial
Linaclotide or Matching PlaceboPhase 31 trial
LinaclotidePhase 2Peptide1 trial
+3 more programs
Active Trials
NCT02559206CompletedEst. Sep 2016
NCT00460811CompletedEst. Apr 2008
NCT02559817TerminatedEst. Aug 2019
+3 more trials
Takeda
TakedaTOKYO, Japan
1 program
1
LubiprostonePhase 31 trial
Active Trials
NCT00380250Completed590Est. Jul 2006
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
1
PlecanatidePhase 2Peptide1 trial
Active Trials
NCT03596905CompletedEst. Nov 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Ironwood PharmaceuticalsLinaclotide
Ironwood PharmaceuticalsLinaclotide or Matching Placebo
Ironwood PharmaceuticalsLinaclotide
TakedaLubiprostone
Bausch HealthPlecanatide
Ironwood PharmaceuticalsLinaclotide Dose A
Ironwood PharmaceuticalsLinaclotide
Ironwood PharmaceuticalsLinaclotide Acetate

Clinical Trials (8)

Total enrollment: 590 patients across 8 trials

An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation

Start: Nov 2015Est. completion: Feb 2018
Phase 4Completed
NCT00938717Ironwood PharmaceuticalsLinaclotide or Matching Placebo

Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Start: Jul 2009Est. completion: Sep 2010
Phase 3Completed

An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation

Start: Sep 2008Est. completion: Mar 2012
Phase 3Completed
NCT00380250TakedaLubiprostone

Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation

Start: May 2005Est. completion: Jul 2006590 patients
Phase 3Completed

Efficacy and Safety of Plecanatide in Children 6 to <18 Years With Irritable Bowel Syndrome With Constipation (IBS-C)

Start: Jun 2018Est. completion: Nov 2024
Phase 2Completed

A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipation

Start: Nov 2015Est. completion: Aug 2019
Phase 2Terminated

Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Start: Oct 2015Est. completion: Sep 2016
Phase 2Completed

Randomized, Double-blind, Dose-range-finding, Phase 2 Study of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Start: Apr 2007Est. completion: Apr 2008
Phase 2Completed

Related Jobs in Gastroenterology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space