Ardelyx
CA - Fremont
Biotechnology1 H-1B visas (FY2023)Focus: Gastrointestinal Therapeutics
Ardelyx is a life sciences company focused on Gastrointestinal Therapeutics.
Gastroenterology
Open Jobs
0
Products & Portfolio (2)
IBSRELA
tenapanor hydrochloride
Peak
ORAL · TABLET
sodium/hydrogen exchanger 3 (NHE3), an antiporter expressed on the apical surface of the small intestine and colon primarily responsible for the absorption of dietary sodium. In vitro and animal studies indicate its major metabolite, M1, is not active against NHE3. By inhibiting NHE3 on the apical surface of the enterocytes, tenapanor reduces absorption of sodium from the small intestine and colon, resulting in an increase in water secretion into the intestinal lumen, which accelerates intestinal transit time and results in a softer stool consistency. Tenapanor has also been shown to reduce abdominal pain by decreasing visceral hypersensitivity and by decreasing intestinal permeability in animal models. In rat model of colonic hypersensitivity, tenapanor reduced visceral hyperalgesia and normalized colonic sensory neuronal excitability.
irritable bowel syndrome with constipation (IBS-C) in adults
2019
0
XPHOZAH
tenapanor
Growth
ORAL · TABLET
2023
0
Open Jobs (0)
No open positions listed yet. Check their careers page directly.
Interview Prep Quick Facts
Portfolio: 2 approved products
Top TAs: Gastroenterology
H-1B (2023): 1 approval
Portfolio Health
Growth1 (50%)
Peak1 (50%)
2 total products
Visa Sponsorship
Sponsors Work Visas
H-1B Petitions (FY2023)
1
Approved
0
Denied
100%
Rate
Source: USCIS H-1B Employer Data Hub