Human Immunodeficiency Virus (HIV)

Infectious Diseases
4
Pipeline Programs
4
Companies
10
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
0
1
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 4 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

CytoDyn
CytoDynVANCOUVER, WA
1 program
1
PRO 140Phase 2/31 trial
Active Trials
NCT02990858Terminated43Est. Jul 2022
Pfizer
PfizerNEW YORK, NY
2 programs
1
PF-04776548Phase 11 trial
Open Label Treatment Access: MaravirocN/A1 trial
Active Trials
NCT00992654No Longer Available
NCT01045317Completed10Est. Feb 2010
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
BudigalimabPhase 1Monoclonal Antibody5 trials
Active Trials
NCT06236438Recruiting840Est. Oct 2031
NCT06119217Active Not Recruiting194Est. Jun 2027
NCT06032546Terminated163Est. Sep 2025
+2 more trials
M&
Merck & Co.RAHWAY, NJ
1 program
1
MK-8527Phase 11 trial
Active Trials
NCT06783192Completed14Est. Oct 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
AbbVieBudigalimab
CytoDynPRO 140
AbbVieBudigalimab
AbbVieBudigalimab
Merck & Co.MK-8527
AbbVieBudigalimab
AbbVieBudigalimab
AbbVieBudigalimab
PfizerPF-04776548

Clinical Trials (10)

Total enrollment: 1,994 patients across 10 trials

Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Start: Apr 2024Est. completion: Oct 2031840 patients
Phase 2/3Recruiting

An Extension Protocol for Subjects Who Successfully Completed PRO140_CD02 or PRO140_CD02_Open Label Study

Start: Nov 2016Est. completion: Jul 202243 patients
Phase 2/3Terminated

Phase 2 Study of TTX-030 and Chemotherapy With or Without Budigalimab for 1L mPDAC Patients

Start: Mar 2024Est. completion: Jun 2027194 patients
Phase 2Active Not Recruiting

A Study to Assess Change in Disease Activity, Adverse Events, and How the Drug Moves Through the Body in Adult Participants Living With Human Immunodeficiency Virus (HIV) Receiving Intravenous (IV) Infusion or Subcutaneous (SC) Injection of Budigalimab and/or ABBV-382

Start: Oct 2023Est. completion: Sep 2025163 patients
Phase 2Terminated

A Drug-Drug Interaction Study of MK 8527 With a Combined Oral Contraceptive (LNG/EE)

Start: Aug 2023Est. completion: Oct 202314 patients
Phase 1Completed

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC) and Other Solid Tumors, Receiving Intravenous (IV) Infusion of Azirkitug (ABBV-514) Alone or in Combination With Budigalimab or Bevacizumab

Start: Nov 2021Est. completion: Jun 2027512 patients
Phase 1Recruiting

Study to Evaluate the Safety and How the Body Handles a Single Dose of Subcutaneous (SC) and Intravenous (IV) Budigalimab in Adult Participants Living With Human Immunodeficiency Virus (HIV)

Start: Mar 2021Est. completion: Oct 202233 patients
Phase 1Completed

TTX-030 in Combination With Immunotherapy and/or Chemotherapy in Subjects With Advanced Cancers

Start: Mar 2020Est. completion: Mar 2024185 patients
Phase 1Completed

A Study To Investigate The Clearance Of PF-04776548 From The Body Following A Very Low (Micro) Dose Of The Compound Using A Low Level Of Radiotracer To Help Quantify Expected Low Concentrations Of PF-04776548 In The Body

Start: Jan 2010Est. completion: Feb 201010 patients
Phase 1Completed
NCT00992654PfizerOpen Label Treatment Access: Maraviroc

A Treatment Access Program To Provide Maraviroc To Eligible Adult Patients Completing A4001050 Study Until Commercial Availability Of Maraviroc (Celsentri) In India

N/ANo Longer Available

Related Jobs in Infectious Diseases

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 actively recruiting trials targeting 1,994 patients
4 companies competing in this space