Hepatocellular Carcinoma

Oncology
82
Pipeline Programs
30
Companies
50
Clinical Trials
9 recruiting
5
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
20
15
30
4
7
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1250%
Small Molecule
1146%
Cell Therapy
14%
+ 65 programs with unclassified modality

On Market (5)

Approved therapies currently available

AstraZeneca
IMJUDOApproved
tremelimumab
AstraZeneca
CTLA-4-directed Blocking Antibody [EPC]intravenous2022
Bayer
NEXAVARApproved
sorafenib
Bayer
Kinase Inhibitor [EPC]oral2005
Bristol Myers Squibb
OPDIVOApproved
nivolumab
Bristol Myers Squibb
Programmed Death Receptor-1 Blocking Antibody [EPC]injection2014
U
SORAFENIB TOSYLATEApproved
sorafenib
Unknown Company
Kinase Inhibitor [EPC]oral2023
Roche
TECENTRIQApproved
atezolizumab
Roche
Programmed Death Receptor-1 Blocking Antibody [EPC]injection2016

Competitive Landscape

52 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
6 programs
1
1
1
IMJUDO(Tremelimumab)Phase 2Monoclonal Antibody3 trials
AZD5851Phase 1/21 trial
AZD5851N/A1 trial
Brazilian Reality of Hepatocellular CarcinomaN/A1 trial
Imjudo & Imfinzi PMSN/A1 trial
+1 more programs
Active Trials
NCT06194461Not Yet Recruiting64Est. Nov 2041
NCT06230328Completed300Est. Nov 2024
NCT06544629Recruiting246Est. Feb 2029
+5 more trials
Bayer
BayerLEVERKUSEN, Germany
3 programs
1
1
1
SorafenibPhase 4Small Molecule1 trial
Regorafenib 40 MGPhase 21 trial
BAY 3547926Phase 11 trial
Active Trials
NCT06764316Recruiting148Est. Dec 2033
NCT04476329Terminated7Est. Dec 2021
NCT01098760Completed151Est. Oct 2013
Roche
2 programs
1
1
1
AtezolizumabPhase 2Monoclonal Antibody1 trial
GC33Phase 1
Active Trials
NCT04563338Active Not Recruiting36Est. Aug 2026
Bristol Myers Squibb
2 programs
1
1
1
NivolumabPhase 3Monoclonal Antibody1 trial
IpilimumabPhase 1/2Monoclonal Antibody1 trial
Active Trials
NCT03682276Unknown32Est. Dec 2023
NCT02576509Completed743Est. Feb 2024
CT
4
1
Anlotinib hydrochloride capsules, Penpulimab injectionPhase 31 trial
AnlotinibPhase 2Small Molecule1 trial
Anlotinib HydrochloridePhase 21 trial
Anlotinib and TQB2450Phase 21 trial
TQB2450 injectionPhase 21 trial
Active Trials
NCT02809534UnknownEst. Dec 2017
NCT04213118UnknownEst. Sep 2023
NCT06031480UnknownEst. Dec 2025
+2 more trials
GC Biopharma
4 programs
1
1
Immuncell-LCPhase 31 trial
MG4101Phase 21 trial
Immuncell-LCN/A1 trial
Long Term Follow-Up Study of Immuncell-LC Group and Non-Treatment Group in Hepatocellular Carcinoma N/A1 trial
Active Trials
NCT06620510CompletedEst. Jun 2025
NCT01890291CompletedEst. Feb 2016
NCT02854839CompletedEst. Sep 2019
+1 more trials
CP
2 programs
1
1
AtezolizumabPhase 3Monoclonal Antibody1 trial
GC33Phase 11 trial
Active Trials
NCT00976170Completed42Est. Sep 2014
NCT05904886Active Not Recruiting687Est. Sep 2026
M&
1 program
1
Elbasvir / Grazoprevir Oral TabletPhase 31 trial
Active Trials
NCT04546802Withdrawn0Est. Jun 2023
Merit Medical
1 program
1
HepaSphere/QuadraSphere MicrospheresPhase 31 trial
Active Trials
NCT01387932Terminated235Est. Feb 2021
DS
1
TivantinibPhase 3Small Molecule1 trial
Active Trials
NCT01755767Completed383Est. Jul 2017
E
8 programs
1
2
3
1
MenatetrenonePhase 2/31 trial
LenvatinibPhase 2Small Molecule1 trial
LenvatinibPhase 2Small Molecule1 trial
Lenvatinib PillPhase 21 trial
LenvatinibPhase 1/2Small Molecule1 trial
+3 more programs
Active Trials
NCT02269995Completed300Est. Dec 2015
NCT03006926Completed104Est. Nov 2022
NCT00946153Completed66Est. Aug 2015
+5 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
3 programs
1
1
1
LivmoniplimabPhase 2/3Monoclonal Antibody1 trial
BudigalimabPhase 2Monoclonal Antibody1 trial
ABBV-400Phase 11 trial
Active Trials
NCT06084481Active Not Recruiting302Est. Jul 2026
NCT05822752Active Not Recruiting130Est. Nov 2026
NCT06109272Recruiting660Est. Sep 2030
TheraBionic
TheraBionicGermany - Ettlingen
2 programs
1
1
TheraBionic DevicePhase 2/31 trial
TheraBionicPhase 21 trial
Active Trials
NCT04327700TerminatedEst. May 2024
NCT04797884UnknownEst. Oct 2024
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
1 program
1
QL1706Phase 2/31 trial
Active Trials
NCT05976568Not Yet RecruitingEst. Sep 2027
Genentech
3 programs
3
AtezolizumabPhase 2Monoclonal Antibody1 trial
Atezolizumab and bevacizumabPhase 2Monoclonal Antibody1 trial
Y-90 TAREPhase 21 trial
Active Trials
NCT06096779Recruiting30Est. Dec 2027
NCT05537402Terminated1Est. Jun 2025
NCT04541173Terminated6Est. Jun 2023
Guerbet
GuerbetFrance - Villepinte
2 programs
1
IDA-TACEPhase 21 trial
Biannual ultrasonographyN/A1 trial
Active Trials
NCT03731923Unknown257Est. Dec 2023
NCT06114082Recruiting128Est. Jun 2026
Knight Therapeutics
1
Quality of LifePhase 21 trial
Quality-of-Life AssessmentN/A1 trial
Active Trials
NCT03812289Terminated9Est. Jan 2024
NCT05157451Withdrawn0Est. Jan 2026
Coherus Oncology
2
CasdozokitugPhase 21 trial
SRF388Phase 21 trial
Active Trials
NCT06679985Recruiting72Est. Sep 2027
NCT05359861Completed30Est. Jul 2025
Auron Therapeutics
1
AMT2003Phase 21 trial
Active Trials
NCT00405873TerminatedEst. Mar 2010
Antengene
AntengeneChina - Shanghai
1 program
1
ATG-008Phase 21 trial
Active Trials
NCT03591965TerminatedEst. Aug 2022
Pfizer
PfizerNEW YORK, NY
1 program
1
CP 675,206Phase 21 trial
Active Trials
NCT01008358Completed20Est. May 2012
Ipsen
1 program
1
CabozantinibPhase 2Small Molecule1 trial
Active Trials
NCT04204850Recruiting20Est. Jun 2026
Alliance Pharmaceuticals
1 program
1
CisplatinPhase 25 trials
Active Trials
NCT02116530Completed401Est. Jun 2017
NCT01275183Completed5Est. Apr 2015
NCT00863512Terminated34Est. Nov 2012
+2 more trials
Delcath
DelcathQUEENSBURY, NY
1 program
1
Delcath Hepatic Delivery SystemPhase 21 trial
Active Trials
NCT02415036Terminated17Est. Dec 2018
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
RamucirumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT00627042Completed42Est. May 2011
Astex Pharmaceuticals
Astex PharmaceuticalsUK - Cambridge
1 program
1
SGI-110Phase 21 trial
Active Trials
NCT01752933CompletedEst. Sep 2015
Taiho Oncology
1
TAC-101Phase 21 trial
Active Trials
NCT00687596TerminatedEst. May 2010
Virogin Biotech
1
VG161Phase 21 trial
Active Trials
NCT05223816RecruitingEst. Dec 2025
Eureka Therapeutics
5
1
ECT204 T cellsPhase 1/21 trial
ET140202 autologous T cell productPhase 11 trial
ET140203 autologous T cell productPhase 11 trial
ET1402L1-ARTEMIS™ T cells -IVPhase 11 trial
Sorafenib combined with ET140202-T cellPhase 11 trial
+1 more programs
Active Trials
NCT03998033TerminatedEst. Dec 2020
NCT04502082TerminatedEst. Aug 2024
NCT03888859CompletedEst. Dec 2020
+3 more trials
Apollomics
ApollomicsFOSTER CITY, CA
1 program
1
APL-501Phase 1/21 trial
Active Trials
NCT03655613TerminatedEst. Dec 2021

+22 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
BayerSorafenib
AstraZenecaTremelimumab
Chugai PharmaAtezolizumab
Chia Tai TianQing Pharmaceutical GroupAnlotinib hydrochloride capsules, Penpulimab injection
Merck & Co.Elbasvir / Grazoprevir Oral Tablet
Bristol Myers SquibbNivolumab
Alliance PharmaceuticalsCisplatin
Daiichi SankyoTivantinib
Merit MedicalHepaSphere/QuadraSphere Microspheres
Alliance PharmaceuticalsCisplatin
GC BiopharmaImmuncell-LC
Alliance PharmaceuticalsCisplatin
Alliance PharmaceuticalsCisplatin
AbbVieLivmoniplimab
Qilu PharmaceuticalQL1706

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 6,601 patients across 50 trials

Hepatocellular Carcinoma - Advanced Stage - Sorafenib Trial in Taiwanese Patients

Start: Aug 2010Est. completion: Oct 2013151 patients
Phase 4Completed

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

Start: May 2025Est. completion: Mar 20301,220 patients
Phase 3Recruiting

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

Start: Sep 2023Est. completion: Sep 2026687 patients
Phase 3Active Not Recruiting
NCT05862337Chia Tai TianQing Pharmaceutical GroupAnlotinib hydrochloride capsules, Penpulimab injection

Anlotinib Hydrochloride Capsules Combined With Penpulimab Injection for the Treatment of Hepatocellular Carcinoma at High Risk of Recurrence.

Start: May 2023Est. completion: Dec 2026
Phase 3Recruiting
NCT04546802Merck & Co.Elbasvir / Grazoprevir Oral Tablet

HepATocellular Cancer Hcv Therapy Study

Start: Sep 2019Est. completion: Jun 20230
Phase 3Withdrawn

An Investigational Immuno-therapy Study of Nivolumab Compared to Sorafenib as a First Treatment in Patients With Advanced Hepatocellular Carcinoma

Start: Dec 2015Est. completion: Feb 2024743 patients
Phase 3Completed

Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Cancer Receiving Highly Emetogenic Chemotherapy

Start: Aug 2014Est. completion: Jun 2017401 patients
Phase 3Completed

Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma (HCC) Who Have Been Treated With One Prior Therapy

Start: Dec 2012Est. completion: Jul 2017383 patients
Phase 3Completed
NCT01387932Merit MedicalHepaSphere/QuadraSphere Microspheres

HepaSphere/Quadrasphere Microspheres for Delivery of Doxorubicin for the Treatment of Hepatocellular Cancer

Start: Jun 2011Est. completion: Feb 2021235 patients
Phase 3Terminated

Chemotherapy or Observation in Treating Patients With Early Stage Non-Small Cell Lung Cancer

Start: Mar 2009Est. completion: Nov 201234 patients
Phase 3Terminated

Efficacy and Safety of Immuncell-LC Group and Non-treatment Group in Hepatocelluar Carcinoma Patients

Start: Jul 2008Est. completion: Nov 2012
Phase 3Completed

Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors

Start: Apr 2004Est. completion: Apr 20051 patients
Phase 3Terminated

Cisplatin Plus Etoposide With or Without Paclitaxel in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Start: Apr 1998Est. completion: Jan 2006587 patients
Phase 3Completed
NCT06109272AbbVieLivmoniplimab

A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

Start: Jan 2024Est. completion: Sep 2030660 patients
Phase 2/3Recruiting

A Study of QL1706 in Combination With Bevacizumab and/or Chemotherapy as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma

Start: Sep 2023Est. completion: Sep 2027
Phase 2/3Not Yet Recruiting
NCT04797884TheraBionicTheraBionic Device

Electromagnetic Fields Versus Placebo For Child-Pugh A and B Patients With Advanced Hepatocellular Carcinoma

Start: Jul 2023Est. completion: Oct 2024
Phase 2/3Unknown
NCT00165633EisaiMenatetrenone

A Phase II/III Clinical Study on Inhibitory Effects of E0167 on Recurrence of Hepatocellular Carcinoma

Start: Mar 2004Est. completion: Mar 2007540 patients
Phase 2/3Terminated

A Trial of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma

Start: Dec 2024Est. completion: Sep 202772 patients
Phase 2Recruiting

A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis

Start: Jul 2024Est. completion: Dec 202730 patients
Phase 2Recruiting

An Open-Label, Multiple-Center, Phase IIa/IIb Clinical Trial to Evaluate the Efficacy, Safety and Tolerability of VG161 as Monotherapy and in Combination With Nivolumab for Treatment of Patients With Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

Start: Jan 2024Est. completion: Dec 2025
Phase 2Recruiting

Y-90 Versus SBRT for Inoperable HCC

Start: Dec 2023Est. completion: Jan 20260
Phase 2Withdrawn

Anlotinib and TQB2450 in Advanced Hepatocellular Carcinoma After Failure of Prior Immune Checkpoint Inhibitors

Start: Oct 2023Est. completion: Dec 2025
Phase 2Unknown
NCT05537402GenentechAtezolizumab and bevacizumab

LOcoregional vs Systemic Therapy in Patients With BCLC Stage B HCC

Start: Sep 2023Est. completion: Jun 20251 patients
Phase 2Terminated

Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC)

Start: Sep 2023Est. completion: Nov 2026130 patients
Phase 2Active Not Recruiting

Lenvatinib After Progression on Atezolizumab-bevacizumab in Hepatocellular Carcinoma

Start: Jul 2023Est. completion: Nov 202750 patients
Phase 2Active Not Recruiting

TACE Using Idarubicin Versus Doxorubicin Chemoemulsion in Patients with Hepatocellular Carcinoma

Start: Apr 2023Est. completion: Jun 2026128 patients
Phase 2Recruiting

Neoadjuvant Combination Therapy of Lenvatinib and TACE for Transplant-Eligible Large Hepatocellular Carcinoma Patients

Start: Jun 2022Est. completion: Dec 202750 patients
Phase 2Enrolling By Invitation

Trial of Atezolizumab and Bevacizumab With SRF388 or Placebo in Patients With Hepatocellular Carcinoma

Start: Apr 2022Est. completion: Jul 202530 patients
Phase 2Completed
NCT05113186EisaiLenvatinib Pill

Neoadjuvant and Adjuvant Lenvatinib in HCC Patients Treated by Percutaneous Ablative

Start: Feb 2022Est. completion: Oct 202632 patients
Phase 2Active Not Recruiting

TQB2450 Plus Anlotinib as Adjuvant Therapy in HCC Patients at High Risk of Recurrence After Resection

Start: Jan 2022Est. completion: May 2024
Phase 2Unknown
NCT04563338RocheAtezolizumab

An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)

Start: Jun 2021Est. completion: Aug 202636 patients
Phase 2Active Not Recruiting

Study Of Intrabucally Administered Electromagnetic Fields and Regorafenib

Start: Jan 2021Est. completion: May 2024
Phase 2Terminated
NCT04476329BayerRegorafenib 40 MG

Optimization for Regorafenib in HCC

Start: Jan 2021Est. completion: Dec 20217 patients
Phase 2Terminated

Study of Atezolizumab and Bevacizumab With Y-90 TARE in Patients With Unresectable Hepatocellular Carcinoma (HCC)

Start: Nov 2020Est. completion: Jun 20236 patients
Phase 2Terminated
NCT04204850IpsenCabozantinib

Cabozantinib to Treat Recurrent Liver Cancer Post Transplant

Start: Aug 2020Est. completion: Jun 202620 patients
Phase 2Recruiting

Anlotinib Combined With TACE in Hepatocellular Carcinoma Patients at High Risk of Post Surgery Recurrence

Start: Apr 2020Est. completion: Sep 2023
Phase 2Unknown

Dual TORC1/TORC2 Inhibitor ATG-008 (CC-223) in HBV Positive Advanced Hepatocellular Carcinoma (HCC) Subjects

Start: Aug 2018Est. completion: Aug 2022
Phase 2Terminated

Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer

Start: May 2018Est. completion: Oct 202670 patients
Phase 2Recruiting

A Study of MG4101 (Allogeneic Natural Killer Cell) for Intermediate-stage of Hepatocellular Carcinoma

Start: Nov 2016Est. completion: Sep 2019
Phase 2Completed

A Study of Anlotinib in Patients With Hepatocellular Carcinoma

Start: Sep 2016Est. completion: Dec 2017
Phase 2Unknown
NCT02415036DelcathDelcath Hepatic Delivery System

Melphalan for Use With the Hepatic Delivery System Treatment in Patients With Unresectable Hepatocellular Carcinoma or Intra Hepatic Cholangiocarcinoma

Start: Jun 2014Est. completion: Dec 201817 patients
Phase 2Terminated

SGI-110 in the Treatment of Advanced Hepatocellular Carcinoma (HCC)

Start: Dec 2012Est. completion: Sep 2015
Phase 2Completed

Anti-CTLA-4 Human Monoclonal Antibody CP-675,206 in Patients With Advanced Hepatocellular Carcinoma

Start: Dec 2008Est. completion: May 201220 patients
Phase 2Completed

Study of TAC-101 as Second Line Treatment in Patients With Advanced Hepatocellular Carcinoma Who Received Sorafenib as First Line Therapy

Start: Aug 2008Est. completion: May 2010
Phase 2Terminated

Study of IMC-1121B (Ramucirumab) in Participants With Liver Cancer Who Have Not Previously Been Treated With Chemotherapy

Start: Feb 2008Est. completion: May 201142 patients
Phase 2Completed

Gemcitabine, Oxaliplatin, Tarceva &/or Cisplatin in HCC & Biliary Tree Cancers

Start: Aug 2007Est. completion: Mar 201733 patients
Phase 2Terminated

A Rollover Study for Patients Who Received Tremelimumab in Other Protocols, to Allow the Patients Access to Tremelimumab Until This Agent Becomes Commercially Available or Development is Discontinued.

Start: Mar 2007Est. completion: Oct 202337 patients
Phase 2Completed

Study to Evaluate Tumour Response in Cancer Patients With Advanced Hepatocellular Carcinoma (Liver Cancer) With AMT2003

Start: Mar 2007Est. completion: Mar 2010
Phase 2Terminated

Adjuvant Chemoradiotherapy and Interferon Alfa in Treating Patients With Resected Pancreatic Cancer

Start: Mar 2003Est. completion: Feb 201189 patients
Phase 2Completed

Gemcitabine and Cisplatin in Treating Patients With Metastatic Breast Cancer

Start: Aug 1997Est. completion: May 200659 patients
Phase 2Completed

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

7 late-stage (Phase 3) programs — potential near-term approvals
9 actively recruiting trials targeting 6,601 patients
30 companies competing in this space