Heart Failure, Diastolic

Cardiovascular
3
Pipeline Programs
2
Companies
2
Clinical Trials
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
3
Early DiscoveryClinical DevelopmentMarket

On Market (2)

Approved therapies currently available

Astellas
LEXISCANApproved
regadenoson
Astellas
Adenosine Receptor Agonist [EPC]intravenous2008
U
REGADENOSONApproved
regadenoson
Unknown Company
Adenosine Receptor Agonist [EPC]intravenous2024

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Astellas
AstellasChina - Shenyang
1 program
1
regadenosonPhase 41 trial
Active Trials
NCT02589977Completed55Est. Jan 2020
Impulse Dynamics
Impulse DynamicsNY - Pearl River
1 program
Optimizer SMARTN/A1 trial
Active Trials
NCT03240237CompletedEst. Jul 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Astellasregadenoson
Impulse DynamicsOptimizer SMART

Clinical Trials (2)

Total enrollment: 55 patients across 2 trials

NCT02589977Astellasregadenoson

Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF

Start: Nov 2015Est. completion: Jan 202055 patients
Phase 4Completed
NCT03240237Impulse DynamicsOptimizer SMART

CCM in Heart Failure With Preserved Ejection Fraction

Start: May 2018Est. completion: Jul 2023
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 companies competing in this space

Related Indications

Hypertension(361)Heart Failure(347)Coronary Artery Disease(302)Atrial Fibrillation(290)Pulmonary Arterial Hypertension(106)Acute Coronary Syndrome(67)Pulmonary Hypertension(57)Atherosclerosis(44)Hypertension, Pulmonary(34)Essential Hypertension(32)