Glaucoma, Open-Angle

Ophthalmology
10
Pipeline Programs
5
Companies
18
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
6
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Glaukos
GlaukosALISO VIEJO, CA
10 programs
1
3
1
iDose TRPhase 41 trial
G2-TR intraocular implant containing travoprostPhase 31 trial
G2-TR intraocular implant containing travoprostPhase 31 trial
Travoprost Intraocular ImplantPhase 31 trial
Travoprost Intracameral Implant exchanged at Month 12Phase 21 trial
+5 more programs
Active Trials
NCT03255798TerminatedEst. Jun 2019
NCT03624699CompletedEst. Jun 2020
NCT04624698Active Not RecruitingEst. May 2026
+7 more trials
S
SantenCA - Emeryville
1 program
1
Tafluprost/timolol fixed combinationPhase 41 trial
Active Trials
NCT03612817CompletedEst. Jul 2018
Alcon
AlconFORT WORTH, TX
4 programs
1
2
TravatanPhase 31 trial
Travoprost 0.004%/Timolol maleate 0.5% ophthalmic solutionPhase 31 trial
Combination IOP Lowering TherapyPhase 21 trial
OMNI canaloplastyN/A1 trial
Active Trials
NCT05949242Active Not RecruitingEst. Oct 2025
NCT00051194CompletedEst. Jul 2003
NCT00051168Completed502
+1 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
Bimatoprost SRPhase 31 trial
Active Trials
NCT02507687Completed240Est. May 2023
iSTAR Medical
iSTAR MedicalBelgium - Wavre
2 programs
Glaucoma device implantation in a stand-alone procedureN/A1 trial
MINIject CS627 implantN/A1 trial
Active Trials
NCT03624361CompletedEst. Sep 2021
NCT03996200CompletedEst. Feb 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
GlaukosiDose TR
SantenTafluprost/timolol fixed combination
GlaukosTravoprost Intraocular Implant
GlaukosG2-TR intraocular implant containing travoprost
GlaukosG2-TR intraocular implant containing travoprost
AbbVieBimatoprost SR
AlconTravatan
AlconTravoprost 0.004%/Timolol maleate 0.5% ophthalmic solution
GlaukosTravoprost Intracameral Implant exchanged at Month 12
AlconCombination IOP Lowering Therapy
AlconOMNI canaloplasty
GlaukosiStent Inject Implantation
GlaukosiStent Inject Trabecular Micro-Bypass System Continuation Post-Approval Study
iSTAR MedicalMINIject CS627 implant
iSTAR MedicalGlaucoma device implantation in a stand-alone procedure

Showing 15 of 18 trials with date data

Clinical Trials (18)

Total enrollment: 1,150 patients across 18 trials

NCT06848946GlaukosiDose TR

Safety and Efficacy of iDose® TR With Cataract Surgery vs. Cataract Surgery Alone

Start: Jan 2025Est. completion: Jun 2027
Phase 4Recruiting
NCT03612817SantenTafluprost/timolol fixed combination

Preservative-free Tafluprost/Timolol Fixed Combination: Morning vs Evening Dosing

Start: Jan 2017Est. completion: Jul 2018
Phase 4Completed
NCT06066645GlaukosTravoprost Intraocular Implant

Travoprost Intraocular Implant + iStent Infinite vs. iStent Infinite Alone

Start: Sep 2023Est. completion: Feb 2028
Phase 3Recruiting
NCT03868124GlaukosG2-TR intraocular implant containing travoprost

Clinical Study Comparing Two Models of a Travoprost Intraocular Implant

Start: Sep 2018Est. completion: Jun 2024
Phase 3Completed
NCT03519386GlaukosG2-TR intraocular implant containing travoprost

Randomized Study Comparing Two Models of a Travoprost Intraocular Implant to Timolol Maleate Ophthalmic Solution, 0.5%

Start: Jul 2018Est. completion: Apr 2024
Phase 3Completed
NCT02507687AbbVieBimatoprost SR

Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension

Start: Aug 2015Est. completion: May 2023240 patients
Phase 3Completed
NCT00051168AlconTravatan

A Long-term Safety Study of Once-daily Travatan

Start: Jan 2006502 patients
Phase 3Completed
NCT00311389AlconTravoprost 0.004%/Timolol maleate 0.5% ophthalmic solution

A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension

Start: Jan 2003Est. completion: Sep 2004408 patients
Phase 3Completed
NCT06582732GlaukosTravoprost Intracameral Implant exchanged at Month 12

Performance of the Travoprost Intraocular Implant

Start: Mar 2021Est. completion: Nov 2023
Phase 2Completed
NCT00051194AlconCombination IOP Lowering Therapy

A 6-week Safety & Efficacy Study of Combination Intraocular Pressure-lowering Therapy in Patients With Open-angle Glaucoma or Ocular Hypertension

Start: Sep 2002Est. completion: Jul 2003
Phase 2Completed
NCT05949242AlconOMNI canaloplasty

Clinical Outcomes in Cataract Surgery With OMNI Canaloplasty vs Cataract Surgery With OMNI Canaloplasty and Hydrus Stent

Start: Apr 2023Est. completion: Oct 2025
N/AActive Not Recruiting
NCT04624698GlaukosiStent Inject Implantation

iStent Inject New Enrollment Post-Approval Study

Start: Sep 2020Est. completion: May 2026
N/AActive Not Recruiting
NCT04624685GlaukosiStent Inject Trabecular Micro-Bypass System Continuation Post-Approval Study

iStent Inject Trabecular Micro-Bypass System Continuation Post-Approval Study

Start: Jan 2020Est. completion: Dec 2021
N/AUnknown
NCT03996200iSTAR MedicalMINIject CS627 implant

MINIject in Patients With Open Angle Glaucoma Using Single Operator Delivery Tool

Start: Jul 2019Est. completion: Feb 2022
N/ACompleted
NCT03624361iSTAR MedicalGlaucoma device implantation in a stand-alone procedure

MINIject Glaucoma Implant in European Patients

Start: May 2018Est. completion: Sep 2021
N/ACompleted
NCT03624699GlaukosGlaukos iStent inject®

Investigation of the iStent Inject® Devices in Open-Angle Glaucoma

Start: Apr 2018Est. completion: Jun 2020
N/ACompleted
NCT03106181GlaukosiStent inject®

A Comparison of Cataract Surgery Alone and Cataract Surgery With iStent

Start: Feb 2018Est. completion: Dec 2022
N/ACompleted
NCT03255798GlaukosG2 and G3

A Prospective Evaluation of Glaucoma Subjects Treated With Two Second Generation iStents and One iStent Supra

Start: Aug 2017Est. completion: Jun 2019
N/ATerminated

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

6 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 1,150 patients
5 companies competing in this space

Related Indications

Myopia(127)Cataract(116)Open-Angle Glaucoma(102)Glaucoma(92)Dry Eye(74)Age-Related Macular Degeneration(73)Dry Eye Disease(43)Neovascular Age-related Macular Degeneration(40)Macular Degeneration(37)Diabetic Retinopathy(25)