Gastroesophageal Adenocarcinoma

Oncology
7
Pipeline Programs
5
Companies
6
Clinical Trials
4 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
7
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
3100%
+ 4 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
3 programs
3
PaclitaxelPhase 21 trial
TislelizumabPhase 2Monoclonal Antibody1 trial
ZanidatamabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT06043427Recruiting168Est. Dec 2026
NCT07290985Not Yet Recruiting121Est. Dec 2028
NCT07176312Recruiting80Est. Mar 2029
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD0901Phase 21 trial
Active Trials
NCT07069712Recruiting100Est. Sep 2028
Bristol Myers Squibb
1 program
1
Nivolumab 240 MGPhase 21 trial
Active Trials
NCT04021108Active Not Recruiting80Est. Jun 2026
CT
1 program
1
TQB2102 for injectionPhase 21 trial
Active Trials
NCT06767800RecruitingEst. Sep 2027
BeOne Medicines
BeOne MedicinesCA - San Carlos
1 program
1
TislelizumabPhase 2Monoclonal Antibody

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Jazz PharmaceuticalsTislelizumab
Jazz PharmaceuticalsZanidatamab
AstraZenecaAZD0901
Chia Tai TianQing Pharmaceutical GroupTQB2102 for injection
Jazz PharmaceuticalsPaclitaxel
Bristol Myers SquibbNivolumab 240 MG

Clinical Trials (6)

Total enrollment: 549 patients across 6 trials

NCT07290985Jazz PharmaceuticalsTislelizumab

AACR Adaptive Biomarker-Driven Organ Preservation Trial in Gastroesophageal Adenocarcinomas

Start: Mar 2026Est. completion: Dec 2028121 patients
Phase 2Not Yet Recruiting
NCT07176312Jazz PharmaceuticalsZanidatamab

Zanidatamab in Combination With Pembrolizumab and Chemotherapy in HER2 and PD-L1 Positive Metastatic Gastroesophageal Adenocarcinoma (GEA) Patients

Start: Jan 2026Est. completion: Mar 202980 patients
Phase 2Recruiting
NCT07069712AstraZenecaAZD0901

A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma

Start: Jul 2025Est. completion: Sep 2028100 patients
Phase 2Recruiting
NCT06767800Chia Tai TianQing Pharmaceutical GroupTQB2102 for injection

A Clinical Trial Evaluating TQB2102 for Injection in Combination With Behmosubaisumab/Payamprolizumab With or Without Chemotherapy in Unresectable Locally Advanced, Recurrent, or Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastroesophageal Adenocarcinoma

Start: Nov 2024Est. completion: Sep 2027
Phase 2Recruiting
NCT06043427Jazz PharmaceuticalsPaclitaxel

Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma

Start: Apr 2024Est. completion: Dec 2026168 patients
Phase 2Recruiting
NCT04021108Bristol Myers SquibbNivolumab 240 MG

Phase II Study of Short Course FOLFOX Chemotherapy With Either Nivolumab or Nivolumab + Radiation in the First Line Treatment of Metastatic or Unresectable Gastroesophageal Cancers (BMS Protocol CA209-76L)

Start: Jul 2019Est. completion: Jun 202680 patients
Phase 2Active Not Recruiting

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 actively recruiting trials targeting 549 patients
5 companies competing in this space

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