Epilepsy, Tonic-Clonic

Neurology
8
Pipeline Programs
3
Companies
3
Clinical Trials
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
4
4
Early DiscoveryClinical DevelopmentMarket

On Market (4)

Approved therapies currently available

UP
KEPPRAApproved
levetiracetam
UCB Pharma
oral2003
UP
KEPPRA XRApproved
levetiracetam
UCB Pharma
oral2008
U
LEVETIRACETAMApproved
levetiracetam
Unknown Company
oral2012
U
SPRITAMApproved
levetiracetam
Unknown Company
oral2015

Competitive Landscape

3 companies ranked by most advanced pipeline stage

UP
UCB PharmaBelgium - Brussels
2 programs
2
1
LEVETIRACETAMPhase 31 trial
LevetiracetamPhase 31 trial
Active Trials
NCT00150787Completed250Est. Nov 2005
NCT00150813Completed66Est. May 2007
Praxis Precision Medicines
1 program
1
vormatroginePhase 3
Precision BioSciences
1 program
1
vormatroginePhase 31 trial
Active Trials
NCT07287163Enrolling By Invitation700Est. Dec 2028

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Precision BioSciencesvormatrogine
UCB PharmaLevetiracetam
UCB PharmaLEVETIRACETAM

Clinical Trials (3)

Total enrollment: 1,016 patients across 3 trials

NCT07287163Precision BioSciencesvormatrogine

Clinical Trial of Vormatrigine in Adult Patients With Epilepsy

Start: Oct 2025Est. completion: Dec 2028700 patients
Phase 3Enrolling By Invitation
NCT00150813UCB PharmaLevetiracetam

Monotherapy With Levetiracetam in Patients Suffering From Epilepsy.

Start: Aug 2005Est. completion: May 200766 patients
Phase 3Completed
NCT00150787UCB PharmaLEVETIRACETAM

Monotherapy With Levetiracetam or Carbamazepine in Patients Suffering From Epilepsy.

Start: Jul 2003Est. completion: Nov 2005250 patients
Phase 3Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
3 companies competing in this space

Related Indications

Multiple Sclerosis(274)Schizophrenia(255)Epilepsy(242)Parkinson Disease(171)Alzheimer's Disease(165)Parkinson's Disease(160)Alzheimer Disease(117)Stroke(102)Relapsing-Remitting Multiple Sclerosis(83)Depression(82)