Migraine

Neurology
69
Pipeline Programs
23
Companies
50
Clinical Trials
7 recruiting
12
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
13
0
7
0
26
23
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1393%
Small Molecule
17%
+ 56 programs with unclassified modality

On Market (12)

Approved therapies currently available

Abbott
DEPAKOTE CPApproved
divalproex sodium
Abbott
oral1990
U
DIVALPROEX SODIUMApproved
divalproex sodium
Unknown Company
oral2009
U
QUDEXY XRApproved
topiramate
Unknown Company
oral2014
AbbVie
QULIPTAApproved
atogepant
AbbVie
Calcitonin Gene-related Peptide Receptor Antagonist [EPC]oral2021
U
RIMEGEPANTApproved
rimegepant
Unknown Company
oral
J&
TOPAMAXApproved
topiramate
Johnson & Johnson
oral1996
J&
TOPAMAX SPRINKLEApproved
topiramate
Johnson & Johnson
oral1998
AbbVie
UBRELVYApproved
ubrogepant
AbbVie
Calcitonin Gene-related Peptide Receptor Antagonist [EPC]oral2019
U
UBROGEPANTApproved
ubrogepant
Unknown Company
U
ZOLMITRIPTANApproved
zolmitriptan
Unknown Company
Serotonin-1b and Serotonin-1d Receptor Agonist [EPC]oral2016
U
ZOMIGApproved
zolmitriptan
Unknown Company
oral1997
AstraZeneca
ZOMIG-ZMTApproved
zolmitriptan
AstraZeneca
oral2001

Competitive Landscape

21 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
10 programs
2
2
6
EletriptanPhase 41 trial
RimegepantPhase 41 trial
RimegepantPhase 41 trial
eletriptanPhase 41 trial
eletriptanPhase 41 trial
+5 more programs
Active Trials
NCT01445067Completed48Est. Sep 2012
NCT01981499Terminated31Est. Apr 2014
NCT01530529Completed12Est. Apr 2012
+12 more trials
Teva
TevaIsrael - Petach Tikva
9 programs
1
5
1
FremanezumabPhase 4Monoclonal Antibody5 trials
FremanezumabPhase 3Monoclonal Antibody1 trial
FremanezumabPhase 3Monoclonal Antibody1 trial
FremanezumabPhase 3Monoclonal Antibody1 trial
FremanezumabPhase 3Monoclonal Antibody1 trial
+4 more programs
Active Trials
NCT07029126Recruiting300Est. Mar 2026
NCT03539393Available
NCT00781456Completed109Est. Aug 2011
+10 more trials
OD
6 programs
4
2
topiramate; almotriptan malatePhase 4
tramadol HCl/acetaminophenPhase 4
topiramatePhase 3
topiramatePhase 3
topiramatePhase 3
+1 more programs
Amgen
AmgenTHOUSAND OAKS, CA
5 programs
3
1
ErenumabPhase 4Monoclonal Antibody1 trial
AMG 333Phase 11 trial
AMG 334 Dose 1Phase 11 trial
ErenumabPhase 1Monoclonal Antibody1 trial
erenumab-aooeN/A1 trial
Active Trials
NCT06150781Recruiting2,842Est. Oct 2027
NCT02132429Terminated16Est. Dec 2014
NCT03499119Completed53Est. Nov 2021
+2 more trials
Abbott
AbbottABBOTT PARK, IL
3 programs
1
1
1
divalproex sodiumPhase 31 trial
AMPLATZER® PFO Occluder DevicePhase 21 trial
PFO ClosureN/A1 trial
Active Trials
NCT00369499Terminated656Est. Jun 2009
NCT00505570Terminated107Est. Feb 2013
NCT00195741Completed300
AbbVie
AbbVieNORTH CHICAGO, IL
3 programs
3
1
AtogepantPhase 31 trial
AtogepantPhase 35 trials
UbrogepantPhase 35 trials
Active Trials
NCT05861427Completed523Est. Mar 2025
NCT06972056Recruiting1,335Est. Dec 2029
NCT06543914Recruiting1,000Est. Feb 2029
+8 more trials
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
3 programs
3
1
Topiramate; PlaceboPhase 31 trial
topiramatePhase 31 trial
topiramate, propranololPhase 3Small Molecule1 trial
Active Trials
NCT00210535Completed110Est. Nov 2006
NCT00210860Completed142Est. Mar 2006
NCT00236561Completed786Est. Dec 2002
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
2 programs
1
1
ZolmitriptanPhase 41 trial
RapimeltPhase 11 trial
Active Trials
NCT01085123Completed10Est. Oct 2010
NCT00637286Completed120Est. May 2005
M&
Merck & Co.RAHWAY, NJ
8 programs
5
1
Telcagepant potassium 150 mgPhase 31 trial
MK0974 Ethanolate formulationPhase 11 trial
MK0974 tabletPhase 11 trial
TopiramatePhase 11 trial
telcagepantPhase 11 trial
+3 more programs
Active Trials
NCT00890357Completed292Est. Jun 2012
NCT01421277Terminated216Est. Mar 2012
NCT00965887Completed36Est. May 2008
+5 more trials
Axsome Therapeutics
Axsome TherapeuticsNY - New York
4 programs
4
AXS-07Phase 31 trial
AXS-07Phase 31 trial
AXS-07Phase 31 trial
AXS-07Phase 31 trial
Active Trials
NCT03896009Completed1,594Est. Dec 2019
NCT04068051Completed706Est. Sep 2020
NCT04163185Completed302Est. Mar 2020
+1 more trials
Alder Therapeutics
Alder TherapeuticsSweden - Solna
3 programs
2
1
EptinezumabPhase 3Monoclonal Antibody1 trial
ALD1910Phase 11 trial
ALD403Phase 11 trial
Active Trials
NCT04197349Completed96Est. Aug 2020
NCT01772524Completed163Est. Feb 2014
NCT04152083Completed485Est. Jul 2020
Novartis
NovartisBASEL, Switzerland
2 programs
1
ErenumabPhase 3Monoclonal Antibody5 trials
AimovigN/A1 trial
Active Trials
NCT05177406Completed1,839Est. Dec 2020
NCT06237062Terminated37Est. Nov 2024
NCT05375097Completed162Est. May 2021
+3 more trials
Curonix
CuronixFL - Pompano Beach
1 program
1
StimRelieve Halo SystemPhase 31 trial
Active Trials
NCT02725554WithdrawnEst. May 2025
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
3 programs
2
GalcanezumabPhase 2Monoclonal Antibody1 trial
LasmiditanPhase 21 trial
Migraine AppN/A1 trial
Active Trials
NCT03559088Completed120Est. Apr 2019
NCT02959177Completed459Est. Jan 2019
NCT00384774Completed130Est. Jun 2007
UP
UCB PharmaBelgium - Brussels
2 programs
1
LacosamidePhase 21 trial
levetiracetamN/A1 trial
Active Trials
NCT00203216Completed31Est. Sep 2005
NCT00440518Completed218Est. Jul 2008
Biohaven
BiohavenNEW HAVEN, CT
1 program
1
BHV-2100Phase 21 trial
Active Trials
NCT06603623CompletedEst. Mar 2025
Ipsen
IpsenChina - Tianjin
1 program
1
Botulinum toxin type APhase 21 trial
Active Trials
NCT00301665Completed138Est. Mar 2005
Vedanta Biosciences
Vedanta BiosciencesMA - Cambridge
1 program
Allay LampN/A1 trial
Active Trials
NCT04841083Completed182Est. Dec 2022
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
Arm A - Carotid Sinus Massage + TrendelenburgN/A1 trial
Active Trials
NCT06745648RecruitingEst. Dec 2025
Carrick Therapeutics
Carrick TherapeuticsIreland - Dublin
1 program
air insufflationN/A1 trial
Active Trials
NCT02614378CompletedEst. Dec 2016
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
dihydroergotamine mesylateN/A1 trial
Active Trials
NCT00203268CompletedEst. Mar 2005

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
PfizerRimegepant
AbbVieAtogepant
TevaFremanezumab
PfizerRimegepant
AbbVieUbrogepant
PfizerRimegepant
AbbVieAtogepant
AmgenErenumab
NovartisErenumab
TevaFremanezumab
Pfizereletriptan
Pfizereletriptan
AstraZenecaZolmitriptan
PfizerEletriptan
Pfizereletriptan

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 25,110 patients across 50 trials

Rimegepant as Preemptive Treatment for Predictable Trigger-Induced Migraine in Adult Patients in the US

Start: Sep 2025Est. completion: Jan 202760 patients
Phase 4Recruiting

Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

Start: Jul 2025Est. completion: Dec 20291,335 patients
Phase 4Recruiting
NCT06173661TevaFremanezumab

Fremanezumab Treatment of Migraine in Women With Menstrual Migraine Ages 18-45

Start: Mar 2024Est. completion: Jul 202672 patients
Phase 4Active Not Recruiting

Efficacy and Tolerability of Rimegepant for the Acute Treatment of Migraine in Adults Unsuitable for Triptan Use

Start: Oct 2022Est. completion: Jun 2025632 patients
Phase 4Completed

Ubrogepant treatmeNt in mIgraine Patients Utilizing mOnoclonal aNtibodies

Start: Sep 2022Est. completion: Nov 2024164 patients
Phase 4Active Not Recruiting

Safety and Tolerability Study of Daily Dosing Rimegepant in Episodic Migraine Prevention

Start: Mar 2022Est. completion: Jul 2024441 patients
Phase 4Completed

Study to Assess Adverse Events When Ubrogepant Tablets in Combination With Atogepant Tablets Are Used to Treat Adult Participants With Migraine

Start: Mar 2022Est. completion: Apr 2023263 patients
Phase 4Completed

Biomarker and Genetic Predictors of Erenumab Treatment Response

Start: Oct 2020Est. completion: Jan 20231,406 patients
Phase 4Completed

Assessment of Prolonged Safety and tOLerability of in Migraine Patients in a Long-term OpeN-label Study

Start: Sep 2019Est. completion: Mar 2023701 patients
Phase 4Completed
NCT04041284TevaFremanezumab

A Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive Disorder

Start: Sep 2019Est. completion: Aug 2022353 patients
Phase 4Completed

A Trial to Study of the Effects of Eletriptan 40mg on Mild vs Moderate to Severe Pain Intensity of Migraine

Start: Mar 2005Est. completion: Oct 2006220 patients
Phase 4Completed

Prospective Survey of Menstrual Migraine & Prevention With Eletriptan

Start: Aug 200471 patients
Phase 4Completed

ZAP, US. Zomig for Appropriate for Primary Care

Start: Jul 2004Est. completion: May 2005120 patients
Phase 4Completed

Efficacy and Safety of Eletriptan for the Treatment of Migraine in Patients Not Satisfied With Rizatriptan Therapy

Start: Jan 2003Est. completion: Aug 2003127 patients
Phase 4Completed

Safety and Efficacy of Eletriptan for the Treatment of Migraine in Subjects Unsuccessfully Treated With Nonsteroidal Anti-inflammatory Drugs

Start: Nov 2002Est. completion: Dec 2003120 patients
Phase 4Completed
NCT02725554CuronixStimRelieve Halo System

Study of Wireless Nerve Stimulation in the Treatment of Chronic Migraine

Start: May 2025Est. completion: May 2025
Phase 3Withdrawn

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

Start: Nov 2024Est. completion: Dec 2027
Phase 3Recruiting

Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

Start: Sep 2024Est. completion: Sep 2027496 patients
Phase 3Recruiting

Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine

Start: Mar 2024Est. completion: Nov 20261,300 patients
Phase 3Recruiting

Comparative Study of Oral Atogepant Versus Oral Topiramate to Assess Adverse Events in Adult Participants With Migraine

Start: Oct 2023Est. completion: May 2026545 patients
Phase 3Active Not Recruiting

Study of Oral Atogepant Tablets to Assess Change in Disease Activity in Adult Japanese Participants With Episodic Migraine

Start: Jul 2023Est. completion: Mar 2025523 patients
Phase 3Completed

Long-term Extension Study to Assess Adverse Events of Oral Atogepant Tablets in Pediatric Participants (6 to 17 Years of Age) With Migraine

Start: Jun 2023Est. completion: Apr 2032650 patients
Phase 3Enrolling By Invitation

A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

Start: May 2023Est. completion: May 2028450 patients
Phase 3Recruiting
NCT05458011TevaFremanezumab

A Randomized, Double-Blind, Placebo-Controlled Study With an Open-Label Period on Efficacy and Safety of Fremanezumab in Chinese Adults With Migraine

Start: Sep 2022Est. completion: Jun 2024365 patients
Phase 3Completed

Open-Label Study of AXS-07 for the Acute Treatment of Migraine in Adults With a Prior Inadequate Response to an Oral CGRP Inhibitor (EMERGE)

Start: Aug 2022Est. completion: Nov 2024100 patients
Phase 3Completed

A Study to Learn About the Long-term Safety of Rimegepant for the Acute Treatment of Migraine in Chinese Participants

Start: May 2022Est. completion: Feb 2024241 patients
Phase 3Completed

Study of Oral Atogepant When Added to OnabotulinumtoxinA (BOTOX) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Chronic Migraine

Start: Mar 2022Est. completion: May 202575 patients
Phase 3Completed

Long-term Extension Study to Assess Safety and Tolerability of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Pediatric Participants (Ages 6-17)

Start: Jan 2022Est. completion: Jan 20281,200 patients
Phase 3Enrolling By Invitation

Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

Start: Jan 2022Est. completion: May 20261,059 patients
Phase 3Recruiting

A Long-Term Safety and Tolerability Extension Study Evaluating Atogepant for the Prevention of Chronic or Episodic Migraine

Start: Feb 2021Est. completion: Oct 2025596 patients
Phase 3Completed
NCT04464707TevaFremanezumab

A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Participants 6 to 17 Years of Age

Start: Sep 2020Est. completion: Nov 2024292 patients
Phase 3Completed
NCT04530110TevaFremanezumab

A Study to Test if Fremanezumab is Effective in Preventing Migraine in Children and Adolescents

Start: Sep 2020Est. completion: Dec 2025506 patients
Phase 3Completed

Study to Evaluate Oral Ubrogepant in the Acute Treatment of Migraine During the Prodrome in Adult Participants

Start: Aug 2020Est. completion: Apr 2022518 patients
Phase 3Completed
NCT04458857TevaFremanezumab

A Study to Test if Fremanezumab is Effective in Preventing Episodic Migraine in Patients 6 to 17 Years of Age

Start: Jul 2020Est. completion: Mar 2024235 patients
Phase 3Completed

A Study Evaluating Oral Atogepant for the Prevention of Migraine in Japanese Participants With Chronic or Episodic Migraine

Start: Jun 2020Est. completion: Jun 2024186 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of Eptinezumab Administered Intravenously in Participants Experiencing Acute Attack of Migraine

Start: Nov 2019Est. completion: Jul 2020485 patients
Phase 3Completed

Study of Quality of Life in Subjects With Chronic or High-frequency Episodic Migraine and Associated Comorbidities Treated With Erenumab

Start: Oct 2019Est. completion: Jan 20220
Phase 3Withdrawn

Initiating Early Control of Migraine Pain and Associated Symptoms

Start: Oct 2019Est. completion: Mar 2020302 patients
Phase 3Completed

Study of Efficacy and Safety of Erenumab in Adult Chronic Migraine Patients

Start: Aug 2019Est. completion: Apr 2024557 patients
Phase 3Completed

Multimechanistic Treatment Over Time of Migraine Symptoms (MOVEMENT)

Start: Jul 2019Est. completion: Sep 2020706 patients
Phase 3Completed

Maximizing Outcomes in Treating Acute Migraine

Start: Mar 2019Est. completion: Dec 20191,594 patients
Phase 3Completed
NCT03107052TevaFremanezumab

A Study to Explore the Long-Term Safety and Efficacy of Fremanezumab (TEV-48125) for the Prevention of Cluster Headache

Start: Apr 2017Est. completion: Jun 2019275 patients
Phase 3Terminated
NCT02945046TevaFremanezumab

A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH)

Start: Jan 2017Est. completion: May 2019169 patients
Phase 3Terminated
NCT02629861TevaFremanezumab

Efficacy and Safety of 2 Dose Regimens of TEV-48125 Versus Placebo for the Preventive Treatment of Episodic Migraine

Start: Mar 2016Est. completion: Apr 2017875 patients
Phase 3Completed
NCT02621931TevaFremanezumab

Comparing Efficacy and Safety of 2 Dose Regimens of Subcutaneous Administration of TEV-48125 Versus Placebo for the Preventive Treatment of Chronic Migraine

Start: Mar 2016Est. completion: Apr 20171,130 patients
Phase 3Completed
NCT02638103TevaFremanezumab

Efficacy and Safety of Subcutaneous Administration of Fremanezumab (TEV-48125) for the Preventive Treatment of Migraine

Start: Feb 2016Est. completion: Dec 20181,890 patients
Phase 3Completed
NCT00510419Pfizer"Investigational"Auto-injector

A Study to Assess an Auto-injector Being Used to Treat a Migraine Attack

Start: Jul 2007Est. completion: Dec 200773 patients
Phase 3Completed
NCT00442936Merck & Co.Telcagepant potassium 150 mg

Study of Telcagepant (MK-0974) in Participants With Moderate to Severe Acute Migraine With or Without Aura (MK-0974-011)

Start: Feb 2007Est. completion: Oct 20071,380 patients
Phase 3Completed
NCT00210535Johnson & JohnsonTopiramate; Placebo

A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine Attacks in Children

Start: Jun 2005Est. completion: Nov 2006110 patients
Phase 3Completed

An Open Label Extension of a Study Comparing Topiramate and Amitriptyline in Migraine Prevention.

Start: Sep 2004Est. completion: Mar 2006142 patients
Phase 3Completed

Related Jobs in Neurology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

26 late-stage (Phase 3) programs — potential near-term approvals
7 actively recruiting trials targeting 25,110 patients
23 companies competing in this space