End Stage Renal Failure With Renal Transplant

Nephrology
1
Pipeline Programs
1
Companies
50
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Novartis
AFINITORApproved
everolimus
Novartis
Kinase Inhibitor [EPC]oral2009

Competitive Landscape

1 companies ranked by most advanced pipeline stage

Novartis
NovartisBASEL, Switzerland
1 program
1
AFINITOR(Everolimus)N/A5 trials
Active Trials
NCT00655252No Longer Available
NCT00149981No Longer Available
NCT05108740No Longer Available
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus
NovartisEverolimus

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 7,182 patients across 50 trials

A Phase IV Study of Safety and Efficacy of Everolimus in Taiwanese Patients With Tuberous Sclerosis Complex Who Have Renal Angiomyolipoma (TSC-AML)

Start: May 2023Est. completion: Nov 20264 patients
Phase 4Active Not Recruiting

Safety and Efficacy of Everolimus (Afinitor®) in Chinese Adult Patients With Angiomyolipoma Associated With Tuberous Sclerosis Complex.

Start: Nov 2018Est. completion: Sep 202040 patients
Phase 4Completed

Phase IV Study of the Safety and Efficacy of Everolimus in Adult Patients With Progressive pNET in China

Start: Mar 2016Est. completion: Feb 202461 patients
Phase 4Completed

Impact of Everolimus on HIV Persistence Post Kidney or Liver Transplant

Start: Feb 2016Est. completion: Jan 201810 patients
Phase 4Completed

SCHEDULE Follow Up Visit 5-7 yr

Start: Jan 2016Est. completion: Sep 201795 patients
Phase 4Completed

Long-term Monitoring of Growth and Development of Pediatric Patients Previously Treated With Everolimus

Start: Dec 2014Est. completion: Dec 202315 patients
Phase 4Completed

Patient Preference for Everolimus in Combination With Exemestane or Capecitabine in Combination With Bevacizumab

Start: Aug 2014Est. completion: Sep 201785 patients
Phase 4Completed

Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporine Versus an Immunosuppressive Regimen With Mycophenolic Acid and Standard Dose of Cyclosporine A

Start: May 2014Est. completion: Oct 2018186 patients
Phase 4Completed

Novartis Everolimus Transition

Start: Feb 2014Est. completion: May 201760 patients
Phase 4Completed

Advancing Renal TRANSplant eFficacy and Safety Outcomes With an eveRolimus-based regiMen (TRANSFORM)

Start: Dec 2013Est. completion: Jan 20182,037 patients
Phase 4Completed

Differentiating Everolimus Versus Sirolimus in Combination With Calcineurin Inhibitors in Kidney Transplant Patients

Start: Dec 2013Est. completion: Jun 20140
Phase 4Withdrawn

Intracoronary Analysis of Cardiac Allograft Vasculopathy by Means of Optical Coherence Tomography

Start: Dec 2013Est. completion: Feb 2023278 patients
Phase 4Unknown

Influence of Exceptional Patient Characteristics on Everolimus Exposure

Start: Aug 2013Est. completion: Jan 201856 patients
Phase 4Completed

Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction

Start: Jul 2013Est. completion: Jul 202055 patients
Phase 4Completed

Everolimus Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Everolimus Study.

Start: May 2013Est. completion: Aug 202034 patients
Phase 4Completed

Evaluate Efficacy Study of Combination Therapy of Everolimus and Low Dose Tacrolimus in Renal Allograft Recipients

Start: Mar 2013Est. completion: Dec 2015234 patients
Phase 4Unknown

An Open Label Study of Postmenopausal Women With Oestrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Treated With Everolimus (RAD001) With Exemestane, With Exploratory Epigenetic Marker Analysis

Start: Jan 2013Est. completion: Aug 201652 patients
Phase 4Completed

Certican (Everolimus) for Recipients of Kidney From HLA-identical Living Donors

Start: Aug 2012Est. completion: Apr 201547 patients
Phase 4Completed

Efficacy of Everolimus in Combination With Tacrolimus in Liver Transplant Recipients

Start: May 2012Est. completion: Aug 2017339 patients
Phase 4Completed

Safety and Efficacy of Everolimus in Metastatic Renal Cell Carcinoma After Failure of First Line Therapy With Sunitinib or Pazopanib

Start: May 2012Est. completion: Apr 201629 patients
Phase 4Completed

A Prospective, Open Label Study of CERtican in KIdney Transplantation

Start: Mar 2012Est. completion: Oct 201354 patients
Phase 4Completed

Effect of Switching to Certican® in Viremia of Hepatitis C Virus in Adult Renal Allograft Recipients

Start: Nov 2011Est. completion: Apr 201530 patients
Phase 4Completed

An Open-label, Multi-center, Expanded Access Study of Everolimus in Participants With Advanced Neuroendocrine Tumors (NETs) (Core Study) and an Extension Study to the Open-label, Multi-center, Expanded Access Study of Everolimus in Patients With Advanced NETs (E1)

Start: Apr 2011Est. completion: Aug 2016246 patients
Phase 4Completed

Cytokines Evaluation in Early Calcineurin Inhibitors Withdrawn on Renal Transplant

Start: Jan 2011Est. completion: Jun 201530 patients
Phase 4Completed

Efficacy and Safety of Everolimus+EC-MPS After Early CNI Elimination vs EC-MPS +Tacrolimus in Renal Transplant Recipients

Start: Dec 2009Est. completion: Jun 201336 patients
Phase 4Completed

SCHEDULE - Scandinavian Heart Transplant Everolimus de Novo Study With Early Calcineurin Inhibitor (CNI) Avoidance

Start: Nov 2009Est. completion: Dec 2012115 patients
Phase 4Completed

Everolimus in de Novo Heart Transplant Recipients

Start: Sep 2009Est. completion: Dec 2013182 patients
Phase 4Completed

Study to Evaluate the Efficacy, Safety and Tolerability of Everolimus in de Novo Renal Transplant Recipients Participating in the Eurotransplant Senior Program

Start: Jul 2009Est. completion: Mar 2013207 patients
Phase 4Terminated

A Study Investigating the Renal Tolerability, Efficacy, and Safety of a CNI-free Versus a Standard Regimen in de Novo Heart Transplant (HTx) Recipients

Start: Feb 2009Est. completion: Mar 2017162 patients
Phase 4Completed

Calcineurin Inhibitor (CNI) Versus Steroid Cessation in Renal Transplantation

Start: Oct 2008Est. completion: Apr 2015152 patients
Phase 4Unknown

Immediate Conversion From Tacrolimus to Everolimus in Stable Maintenance Renal Transplant Recipients

Start: Aug 2008Est. completion: Aug 20080
Phase 4Withdrawn

An Open, Single Centre, Randomised, Parallel Group Study to Investigate Three Different Immunosuppressive Regimens

Start: Jul 2008Est. completion: Jun 201063 patients
Phase 4Completed

Evaluation of Early Conversion to Everolimus From Cyclosporine in de Novo Renal Transplant Recipients

Start: Mar 2008Est. completion: May 2013204 patients
Phase 4Completed

Reduction or Discontinuation of CNI's With Conversion to Everolimus-Based Immunosuppresion

Start: Feb 2007Est. completion: Feb 201060 patients
Phase 4Unknown

Efficacy, Safety and Tolerability of Everolimus in Preventing End-stage Renal Disease in Patients With Autosomal Dominant Polycystic Kidney Disease

Start: Dec 2006Est. completion: Oct 2013431 patients
Phase 4Completed

A Twelve-month, Multicenter, Open-label, Randomized Study of the Safety, Tolerability and Efficacy of Everolimus With Basiliximab, Corticosteroids and Two Different Exposure Levels of Tacrolimus in de Novo Renal Transplant Recipients

Start: Jun 2006Est. completion: Dec 2008228 patients
Phase 4Completed

SOCRATES: Steroid or Cyclosporine Removal After Transplantation Using Everolimus

Start: Mar 2006Est. completion: Jun 2012126 patients
Phase 4Completed

Nordic Everolimus (Certican) Trial in Heart and Lung Transplantation

Start: Dec 2005Est. completion: Feb 2010282 patients
Phase 4Completed

Comparison of CNI-based Regimen Versus CNI-free Regimen in Kidney Transplant Recipients.

Start: Nov 2005Est. completion: Mar 201393 patients
Phase 4Terminated

Efficacy and Safety of Early Versus Delayed Administration of Everolimus in de Novo Renal Transplant Patients

Start: Jun 2005139 patients
Phase 4Completed

Everolimus in Combination With Cyclosporine Microemulsion in de Novo Renal Transplant Recipients

Start: May 2005Est. completion: Jul 2007
Phase 4Completed

Efficacy and Safety of the Switch From Sirolimus to Everolimus in Stable Maintenance Renal Transplant Patients Receiving a Calcineurin Inhibitor Free Regimen

Start: Feb 200520 patients
Phase 4Completed

Everolimus Versus Mycophenolate Mofetil in Combination With Reduced Dose Cyclosporine Microemulsion in Maintenance Heart Transplant Recipients

Start: Aug 2004Est. completion: Dec 2006
Phase 4Completed

Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment

Start: Jun 2017Est. completion: Aug 2027206 patients
Phase 3Active Not Recruiting

Study of the Effect of Everolimus Immunosuppressive Combination Therapies on Renal Function When Used as a Maintenance Treatment for Liver Transplant Patients.

Start: Sep 2015Est. completion: Dec 20200
Phase 3Withdrawn

Evaluation of Oral Care to Prevent Oral Mucositis in ER Positive MBC Patients Treated With Everolimus: Phase 3 RCT

Start: Mar 2015Est. completion: Oct 2018174 patients
Phase 3Completed

Sequentiality of Everolimus and STZ-5FU in Advanced Pancreatic Neuroendocrine Tumor

Start: Oct 2014Est. completion: Jul 2021141 patients
Phase 3Completed

The Efficacy of Everolimus in Reducing Total Native Kidney Volume in Polycystic Kidney Disease Transplanted Recipients

Start: Oct 2014Est. completion: Nov 20173 patients
Phase 3Completed

REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy

Start: Mar 2014Est. completion: Sep 201678 patients
Phase 3Completed

Everolimus Beyond Progress for Patients Who Had Progress Under Everolimus and Exemestane

Start: Jul 2013Est. completion: Jul 20143 patients
Phase 3Terminated

Related Jobs in Nephrology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

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