Chronic Hepatitis C Virus

Infectious Diseases
13
Pipeline Programs
5
Companies
12
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
4
0
7
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
4100%
+ 9 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

GS
Gilead SciencesFOSTER CITY, CA
7 programs
2
1
4
LDV/SOFPhase 3
LDV/SOFPhase 31 trial
LDV/SOFPhase 31 trial
LDV/SOFPhase 31 trial
LDV/SOFPhase 21 trial
+2 more programs
Active Trials
NCT02002767Completed19Est. Jun 2014
NCT01740791Completed103Est. Jan 2014
NCT01726517Completed100Est. Jan 2014
+3 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
2 programs
2
ABT-493/ABT-530Phase 31 trial
Ombitasvir/paritaprevir/ritonavirPhase 3Small Molecule1 trial
Active Trials
NCT02723084Completed136Est. Mar 2017
NCT02806362Withdrawn0Est. Aug 2018
M&
Merck & Co.RAHWAY, NJ
1 program
1
Grazoprevir 100mg / Elbasvir 50 mg FDCPhase 31 trial
Active Trials
NCT02105467Completed421Est. Sep 2015
VP
2 programs
2
VX-222Phase 21 trial
VX-222Phase 21 trial
Active Trials
NCT01581138Completed64Est. Dec 2013
NCT01516918Completed103Est. Dec 2013
Atea Pharmaceuticals
1 program
1
BemnifosbuvirPhase 2Small Molecule1 trial
Active Trials
NCT05904470CompletedEst. Jan 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AbbVieOmbitasvir/paritaprevir/ritonavir
AbbVieABT-493/ABT-530
Merck & Co.Grazoprevir 100mg / Elbasvir 50 mg FDC
Gilead SciencesLDV/SOF
Gilead SciencesLDV/SOF
Gilead SciencesLDV/SOF
Atea PharmaceuticalsBemnifosbuvir
Gilead SciencesLDV/SOF
Vertex PharmaceuticalsVX-222
Vertex PharmaceuticalsVX-222
Gilead SciencesVelpatasvir
Gilead SciencesVelpatasvir

Clinical Trials (12)

Total enrollment: 2,904 patients across 12 trials

NCT02806362AbbVieOmbitasvir/paritaprevir/ritonavir

Study of Ombitasvir/Paritaprevir/Ritonavir in Japanese Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection With End Stage Renal Disease (ESRD) on Hemodialysis (HD)

Start: Sep 2016Est. completion: Aug 20180
Phase 3Withdrawn
NCT02723084AbbVieABT-493/ABT-530

A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Japanese Adults With Genotype 2 Chronic Hepatitis C Virus Infection

Start: Apr 2016Est. completion: Mar 2017136 patients
Phase 3Completed
NCT02105467Merck & Co.Grazoprevir 100mg / Elbasvir 50 mg FDC

Study of Efficacy and Safety of Grazoprevir (MK-5172)/Elbasvir (MK-8742) Combination Regimen for Treatment-Naïve Participants With Chronic Hepatitis C Virus Genotypes 1, 4, and 6 (MK-5172-060)

Start: Jun 2014Est. completion: Sep 2015421 patients
Phase 3Completed

Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination ± Ribavirin for the Treatment of HCV (ION-3)

Start: May 2013Est. completion: Mar 2014647 patients
Phase 3Completed

Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination ± Ribavirin in Treatment-Experienced Subjects With Genotype 1 HCV Infection

Start: Jan 2013Est. completion: Feb 2014441 patients
Phase 3Completed

Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination (FDC) With and Without Ribavirin for the Treatment of HCV

Start: Sep 2012Est. completion: Apr 2014870 patients
Phase 3Completed

A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV

Start: May 2023Est. completion: Jan 2025
Phase 2Completed

Safety and Efficacy of LDV/SOF Fixed-Dose Combination (FDC) ± Ribavirin in HCV Genotype 1 Subjects

Start: Oct 2012Est. completion: Jan 2014100 patients
Phase 2Completed

VX-222 + Telaprevir + Ribavirin for 12 or 16 Weeks in Treatment-Naive Subjects With Genotype 1a Hepatitis C

Start: Jul 2012Est. completion: Dec 201364 patients
Phase 2Completed

A Study to Evaluate the Efficacy and Safety of Quadruple Therapy (VX-222, Telaprevir,Peginterferon-Alfa-2a, Ribavirin) in Subjects With Chronic Hepatitis C With Compensated Cirrhosis

Start: Feb 2012Est. completion: Dec 2013103 patients
Phase 2Completed

Study to Evaluate the Pharmacokinetics of Velpatasvir in Participants With Normal Renal Function and Severe Renal Impairment

Start: Dec 2013Est. completion: Jun 201419 patients
Phase 1Completed

Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Velpatasvir in Participants With Chronic HCV Infection

Start: Nov 2012Est. completion: Jan 2014103 patients
Phase 1Completed

Related Jobs in Infectious Diseases

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

7 late-stage (Phase 3) programs — potential near-term approvals
5 companies competing in this space