Amyloid Cardiomyopathy, Transthyretin-Related

Cardiovascular
2
Pipeline Programs
1
Companies
2
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

1 companies ranked by most advanced pipeline stage

BridgeBio Pharma
BridgeBio PharmaCA - Palo Alto
2 programs
1
1
AcoramidisPhase 31 trial
AG10 oral tabletPhase 11 trial
Active Trials
NCT03294707Completed56Est. May 2018
NCT04988386Active Not Recruiting389Est. May 2028

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
BridgeBio PharmaAcoramidis
BridgeBio PharmaAG10 oral tablet

Clinical Trials (2)

Total enrollment: 445 patients across 2 trials

NCT04988386BridgeBio PharmaAcoramidis

Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants

Start: Oct 2021Est. completion: May 2028389 patients
Phase 3Active Not Recruiting
NCT03294707BridgeBio PharmaAG10 oral tablet

Single and Multiple Ascending Dose Study Assessing the Safety, Tolerability, PK and PD of AG10

Start: Sep 2017Est. completion: May 201856 patients
Phase 1Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
1 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)