Advanced Breast Carcinoma
Oncology
4
Pipeline Programs
3
Companies
3
Clinical Trials
0
Approved Products
Pipeline by Development Stage
Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
1
0
0
0
Early DiscoveryClinical DevelopmentMarket
Drug Modality Breakdown
Small Molecule
2100%
+ 2 programs with unclassified modality
Competitive Landscape
3 companies ranked by most advanced pipeline stage
Knight TherapeuticsQC - Montréal
2 programs1
1
AbemaciclibPhase 2Small Molecule1 trial
AlectinibPhase 1Small Molecule1 trial
Active Trials
Trial Timeline
Clinical trial activity over time
2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Knight TherapeuticsAbemaciclib
Knight TherapeuticsAlectinib
Celldex TherapeuticsONT-10, Varlilumab combination
Clinical Trials (3)
Total enrollment: 52 patients across 3 trials
A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer
Start: Jun 2025Est. completion: Jun 203330 patients
Phase 2Active Not Recruiting
SMMART Adaptive Clinical Treatment (ACT) Trial
Start: Jan 2023Est. completion: May 20260
Phase 1Withdrawn
Study of ONT-10 and Varlilumab to Treat Advanced Ovarian or Breast Cancer
Start: Nov 2014Est. completion: Jun 201622 patients
Phase 1Completed
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Phase Legend
Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available
Key Insights
Small Molecule is the dominant modality (100% of programs)
3 companies competing in this space