Abdominal Aortic Aneurysm

Cardiovascular
4
Pipeline Programs
6
Companies
10
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 9 programs with unclassified modality

Competitive Landscape

6 companies ranked by most advanced pipeline stage

C
CordisFL - Miami Lakes
4 programs
1
1
QUANTUM LP™ STENT GRAFT SYSTEMPhase 31 trial
Cordis AAA Bilateral DevicePhase 1/21 trial
Endovascular AAA repairN/A1 trial
Endovascular AAA repair with InCraft®N/A1 trial
Active Trials
NCT01776450No Longer Available
NCT01664078Completed190Est. Oct 2018
NCT00235118Completed29Est. Feb 2006
+1 more trials
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
EvolocumabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT06081153Not Yet Recruiting44Est. Feb 2028
Life Molecular Imaging
Life Molecular ImagingGermany - Berlin
1 program
1
[18F]-GP1Phase 11 trial
Active Trials
NCT02469376TerminatedEst. Dec 2016
Shape Memory Medical
2 programs
IMPEDE-FX Embolization PlugN/A1 trial
IMPEDE-FX Embolization PlugN/A1 trial
Active Trials
NCT04227054Active Not RecruitingEst. Aug 2028
NCT04751578Active Not RecruitingEst. Apr 2027
Centerline Biomedical
Centerline BiomedicalOH - Cleveland
1 program
Intra-Operative Positioning SystemN/A1 trial
Active Trials
NCT06570785Not Yet RecruitingEst. Nov 2025
Abbott
AbbottABBOTT PARK, IL
1 program
PEVARN/A1 trial
Active Trials
NCT01070069Completed192Est. Sep 2012

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
CordisQUANTUM LP™ STENT GRAFT SYSTEM
CordisCordis AAA Bilateral Device
AmgenEvolocumab
Life Molecular Imaging[18F]-GP1
Centerline BiomedicalIntra-Operative Positioning System
Shape Memory MedicalIMPEDE-FX Embolization Plug
Shape Memory MedicalIMPEDE-FX Embolization Plug
CordisEndovascular AAA repair with InCraft®
AbbottPEVAR

Clinical Trials (10)

Total enrollment: 755 patients across 10 trials

NCT00233688CordisQUANTUM LP™ STENT GRAFT SYSTEM

Study of the Endovascular QUANTUM LP™ Stent Graft System in Abdominal Aortic Aneurysms (AAA)

Start: Nov 2001Est. completion: Apr 2009300 patients
Phase 3Completed
NCT00235118CordisCordis AAA Bilateral Device

Cordis Bilateral AAA Device Compared to Open Surgical Repair of Abdominal Aortic Aneurysms (ARIBA)

Start: Dec 1999Est. completion: Feb 200629 patients
Phase 1/2Completed
NCT06081153AmgenEvolocumab

Mechanistic Clinical Trial of PCSK9 Inhibition for AAA

Start: Jul 2026Est. completion: Feb 202844 patients
Phase 1Not Yet Recruiting
NCT02469376Life Molecular Imaging[18F]-GP1

Evaluation of a New Imagingtechnologie for Thrombosis

Start: Sep 2014Est. completion: Dec 2016
Phase 1Terminated
NCT01776450CordisEndovascular AAA repair

Compassionate Use of the Incraft® AAA Stent Graft System

N/ANo Longer Available
NCT06570785Centerline BiomedicalIntra-Operative Positioning System

IOPS Technology During Cannnulation of Contralateral Limb in EVAR

Start: Jan 2025Est. completion: Nov 2025
N/ANot Yet Recruiting
NCT04751578Shape Memory MedicalIMPEDE-FX Embolization Plug

Abdominal Aortic Aneurysm Sac Healing and Prevention of Endoleaks - Netherlands

Start: Jul 2021Est. completion: Apr 2027
N/AActive Not Recruiting
NCT04227054Shape Memory MedicalIMPEDE-FX Embolization Plug

Abdominal Aortic Aneurysm Sac Healing and Prevention of Endoleaks

Start: Sep 2020Est. completion: Aug 2028
N/AActive Not Recruiting
NCT01664078CordisEndovascular AAA repair with InCraft®

A Multicenter, Open Label, Prospective, Non-randomized Study of the InCraft® Stent Graft System in Subjects With Abdominal Aortic Aneurysms (INSPIRATION)

Start: Jul 2012Est. completion: Oct 2018190 patients
N/ACompleted
NCT01070069AbbottPEVAR

Percutaneous Endovascular Aneurysm Repair (PEVAR) Trial

Start: Apr 2010Est. completion: Sep 2012192 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
6 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)