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Venous Thromboembolism

34
Pipeline Programs
30
Companies
50
Clinical Trials
2 recruiting
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
6
4
13
9
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
4100%
+ 87 programs with unclassified modality

On Market (3)

Approved therapies currently available

Bristol Myers Squibb
ELIQUISApproved
apixaban
Bristol Myers Squibb
oral2025
18.3B Part D
Bristol Myers Squibb
ELIQUIS SPRINKLEApproved
apixaban
Bristol Myers Squibb
oral2025
Johnson & Johnson
XARELTOApproved
rivaroxaban
Johnson & Johnson
Factor Xa Inhibitor [EPC]oral2021

Competitive Landscape

30 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
10 programs
1
1
1
2
ApixabanPhase 4
DalteparinPhase 41 trial
dalteparinPhase 31 trial
dalteparinPhase 21 trial
ApixabanPhase 1
+5 more programs
Active Trials
NCT04969653Completed754,745Est. Jul 2023
NCT01046903Completed503Est. Feb 2011
NCT05022563Completed55,759Est. Sep 2021
+3 more trials
Bristol Myers Squibb
7 programs
1
ApixabanN/A1 trial
Eliquis (VTE Treatment and Prevention of Recurrent VTE) rPMSN/A1 trial
Non-InterventionalN/A1 trial
ApixabanPHASE_11 trial
Apixaban alonePHASE_11 trial
+2 more programs
Active Trials
NCT01885585Completed100Est. May 2015
NCT02546817Completed29Est. Sep 2017
NCT03087474Completed89,383Est. Jun 2018
+4 more trials
ViiV Healthcare
ViiV HealthcareNC - Durham
5 programs
1
1
2
1
FondaparinuxPhase 4
FondaparinuxPhase 3
Fondaparinux sodiumPhase 3
fondaparinux sodiumPhase 2/3
GW813893Phase 2
Leo Pharma
Leo PharmaDenmark - Ballerup
4 programs
1
2
TinzaparinPhase 41 trial
tinzaparinPhase 41 trial
WarfarinPhase 31 trial
TinzaparinN/A1 trial
Active Trials
NCT03099031Completed420Est. May 2017
NCT01130025Completed900Est. May 2014
NCT00851864Completed13Est. May 2011
+1 more trials
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
2 programs
1
XARELTO(Rivaroxaban)PHASE_3
XARELTO(Rivaroxaban)PHASE_3
Dong-A ST
Dong-A STKorea - Seoul
1 program
1
edoxabanPhase 41 trial
Active Trials
NCT07852637Not Yet Recruiting2,300Est. Dec 2030
Astellas
AstellasChina - Shenyang
7 programs
3
4
YM150Phase 31 trial
YM150Phase 31 trial
YM150Phase 31 trial
YM150Phase 31 trial
YM150Phase 2/31 trial
+2 more programs
Active Trials
NCT00913120Completed610Est. Mar 2010
NCT00902928Completed1,992Est. Aug 2010
NCT00917254Completed369Est. Jan 2010
+4 more trials
Sandoz
SandozAustria - Kundl
2 programs
2
AbelacimabPhase 3Monoclonal Antibody
AbelacimabPhase 3Monoclonal Antibody
Anthos Therapeutics
Anthos TherapeuticsMA - Cambridge
2 programs
2
AbelacimabPhase 3Monoclonal Antibody
AbelacimabPhase 3Monoclonal Antibody
Quercis Pharma
Quercis PharmaSwitzerland - Zug
1 program
1
Kinisoquin™Phase 31 trial
Active Trials
NCT06861088Recruiting480Est. Oct 2029
PharmaDiall
PharmaDiallRussia - Moscow
1 program
1
Dimolegin 40 mgPhase 21 trial
Active Trials
NCT05189002Unknown240Est. Dec 2022
Sirius Therapeutics
1
SRSD107Phase 21 trial
Active Trials
NCT07140523Recruiting450Est. Oct 2026
Tetherex Pharmaceuticals
Tetherex PharmaceuticalsOK - Oklahoma City
1 program
1
SelK2Phase 21 trial
Active Trials
NCT03812328Completed207Est. Nov 2019
vTv Therapeutics
vTv TherapeuticsNC - High Point
1 program
1
TTP889Phase 21 trial
Active Trials
NCT00119457Completed300Est. Apr 2006
Ono Pharmaceutical
Ono PharmaceuticalJapan - Osaka
1 program
1
ONO-7684Phase 11 trial
Active Trials
NCT03919890Completed72Est. Aug 2019
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
14 programs
Dabigatran EtexilateN/A1 trial
RE-COVERY DVT/PE: Global Study on Treatment Secondary Prevention of Acute Venous ThromboembolismN/A1 trial
dabigatranN/A1 trial
BIBR 1048PHASE_21 trial
BIBR 1048 capsulePHASE_21 trial
+9 more programs
Active Trials
NCT05536791Withdrawn0Est. Oct 2024
NCT02596230Completed7,797Est. Mar 2019
NCT01153698Terminated167Est. Dec 2011
+11 more trials
Daiichi Sankyo
Daiichi SankyoChina - Shanghai
8 programs
EdoxabanN/A1 trial
EdoxabanN/A1 trial
DU-176bPHASE_21 trial
DU-176b 15mgPHASE_21 trial
15mg DU-176bPHASE_31 trial
+3 more programs
Active Trials
NCT02952599Completed352Est. Oct 2019
NCT02943993Completed2,809Est. Dec 2020
NCT01203072Completed523Est. Jul 2008
+5 more trials
GSK
GSKLONDON, United Kingdom
5 programs
GW813893PHASE_21 trial
fondaparinux sodiumPHASE_2_31 trial
FondaparinuxPHASE_31 trial
Fondaparinux sodiumPHASE_31 trial
FondaparinuxPHASE_41 trial
Active Trials
NCT00541320Withdrawn0
NCT00531843Completed105Est. Jun 2008
NCT00493896Terminated27Est. Apr 2010
+2 more trials
Regeneron
RegeneronTARRYTOWN, NY
3 programs
REGN7508PHASE_21 trial
REGN9933PHASE_21 trial
REGN9933PHASE_21 trial
Active Trials
NCT06454630Completed179Est. Jan 2025
NCT05618808Completed373Est. May 2024
NCT06299111Completed195Est. Mar 2026
Inari Medical
Inari MedicalCA - Irvine
2 programs
ClotTriever SystemN/A1 trial
Percutaneous mechanical thrombectomyN/A1 trial
Active Trials
NCT05701917Recruiting300Est. Jul 2028
NCT06495996Completed66Est. Nov 2025
Eisai
EisaiChina - Liaoning
2 programs
Dalteparin sodiumN/A1 trial
dalteparin injectionPHASE_31 trial
Active Trials
NCT01050153Completed50Est. Dec 2011
NCT00876915Terminated218Est. Dec 2014
Sanofi
SanofiPARIS, France
2 programs
Epidemiology of Venous ThromboembolismN/A1 trial
SR123781APHASE_2_32 trials
Active Trials
NCT00456196Completed5,451Est. Jun 2009
NCT00338897Completed1,090Est. May 2007
NCT00123565Completed1,257Est. May 2007
Bayer
BayerLEVERKUSEN, Germany
2 programs
Global Anticoagulant Registry in the FIELD- Venous Thromboembolic EventsN/A1 trial
Use of Oral Contraceptives (OCs) Containing Dienogest and Risk of Venous ThromboembolismN/A1 trial
Active Trials
NCT02155491Completed10,679Est. Sep 2020
NCT00523614Completed3,400Est. Jun 2008
Medtronic
MedtronicNJ - Phillipsburg
1 program
SCDN/A1 trial
Active Trials
NCT03044574Completed407Est. Dec 2018
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
VTE Prophylaxis Guidelines in Hospitalized EldersN/A1 trial
Active Trials
NCT03025100CompletedEst. Mar 2017
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
blood testsN/A1 trial
Active Trials
NCT01608919Terminated4Est. Jan 2014
Ionis Pharmaceuticals
1 program
ISIS-FXIRx Dose #2PHASE_21 trial
Active Trials
NCT01713361Completed315Est. Aug 2014
Takeda
TakedaTOKYO, Japan
1 program
TAK-442PHASE_21 trial
Active Trials
NCT00641732Completed1,045Est. Oct 2008
Hamilton medical
Hamilton medicalSwitzerland - Bonaduz
1 program
Anti-Embolism Graduated Pressure StockingsPHASE_31 trial
Active Trials
NCT01234064Completed50Est. Dec 2011
Huadong Medicine
Huadong MedicineChina - Hangzhou
1 program
RivaroxabanPHASE_31 trial
Active Trials
NCT04066764Unknown200Est. Oct 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Dong-A STedoxaban
GSKFondaparinux
Leo PharmaTinzaparin
PfizerDalteparin
Leo Pharmatinzaparin
Quercis PharmaKinisoquin™
Huadong MedicineRivaroxaban
Bristol Myers SquibbDebriefing and educative components
Boehringer Ingelheimdabigatran etexilate
Boehringer Ingelheimdabigatran etexilate
Daiichi Sankyo15mg DU-176b
Hamilton medicalAnti-Embolism Graduated Pressure Stockings
Leo PharmaWarfarin
Daiichi Sankyoedoxaban tosylate
Eisaidalteparin injection

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 28,517 patients across 50 trials

Edoxaban Versus Apixaban in Cancer-Associated Venous Thromboembolism

Start: Nov 2026Est. completion: Dec 20302,300 patients
Phase 4Not Yet Recruiting
NCT01467583GSKFondaparinux

Fondaparinux in Critically Ill Patients With Renal Failure

Start: Nov 2011Est. completion: Nov 201332 patients
Phase 4Completed

Safety and Efficacy of Therapeutic Anticoagulation With Tinzaparin During Pregnancy Via Weight-based Dosing

Start: Oct 2007Est. completion: May 201113 patients
Phase 4Completed

Dalteparin vs Unfractionated Heparin For The Prevention Of Venous Thromboembolism (VTE) In Hospitalized Acutely Ill Medical Patients

Start: Jun 2007Est. completion: Jul 200884 patients
Phase 4Terminated

Long-Term Low-Molecular-Weight Heparin Versus Oral Anticoagulants in Deep Venous Thrombosis

Start: Jan 2002Est. completion: Jan 2005241 patients
Phase 4Completed

The Effect of Kinisoquin™ on Thromboembolic Events in Patients With Metastatic or Locally Advanced Pancreatic Cancer

Start: Dec 2025Est. completion: Oct 2029480 patients
Phase 3Recruiting

Rivaroxaban and Vitamin K Antagonists for the Anticoagulation for the Implantation of Vena Cava Filters

Start: May 2020Est. completion: Oct 2024200 patients
Phase 3Unknown
NCT04141254Bristol Myers SquibbDebriefing and educative components

Impact of Early Debriefing and Enhanced Educative Components on Direct Oral Anticoagulant Adherence After Venous Thromboembolism.

Start: Dec 2019Est. completion: Dec 2021150 patients
Phase 3Unknown

Safety of Dabigatran Etexilate in Blood Clot Prevention in Children

Start: Sep 2014Est. completion: Nov 2019214 patients
Phase 3Completed

Open Label Study Comparing Efficacy and Safety of Dabigatran Etexilate to Standard of Care in Paediatric Patients With Venous Thromboembolism (VTE)

Start: Sep 2013Est. completion: Nov 2019267 patients
Phase 3Completed

Safety and Pharmacokinetics Study of DU-176b Administered to Patients With Severe Renal Impairment Undergoing Orthopedic Surgery of The Lower Limbs

Start: Mar 2012Est. completion: Dec 201280 patients
Phase 3Completed
NCT01234064Hamilton medicalAnti-Embolism Graduated Pressure Stockings

Graduated Compression Stockings (GCS) Pilot Substudy

Start: Nov 2010Est. completion: Dec 201150 patients
Phase 3Completed

Long-Term Innohep® Treatment Versus a Vitamin K Antagonist (Warfarin) for the Treatment of Venous Thromboembolism (VTE) in Cancer

Start: Aug 2010Est. completion: May 2014900 patients
Phase 3Completed
NCT00986154Daiichi Sankyoedoxaban tosylate

Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots. (The Edoxaban Hokusai-VTE Study).

Start: Oct 2009Est. completion: Apr 20138,292 patients
Phase 3Completed
NCT00876915Eisaidalteparin injection

A Study of Dalteparin Prophylaxis in High-Risk Ambulatory Cancer Patients

Start: Jul 2009Est. completion: Dec 2014218 patients
Phase 3Terminated

Prevention of Venous Thromboembolism in Subjects Undergoing Hip Fracture Surgery or Surgery in the Lower Extremities

Start: Jun 2009Est. completion: Apr 2010101 patients
Phase 3Completed

Prevention of Recurrence of Venous Thromboembolism in Patients With a History of Venous Thromboembolism

Start: Jun 2009Est. completion: Dec 201087 patients
Phase 3Completed

A Study to Assess the Effect of YM150 for Prevention of Venous Thromboembolism in Patients Undergoing Major Abdominal Surgery

Start: Jun 2009Est. completion: Apr 2010156 patients
Phase 3Completed

YM150 for Prevention of Venous Thromboembolism in Patients With Acute Medical Illness

Start: May 2009Est. completion: Apr 201052 patients
Phase 3Completed

A Phase 3 Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty

Start: Mar 2009Est. completion: Feb 2010716 patients
Phase 3Completed

Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Hip Fracture Surgery

Start: Oct 2008Est. completion: Feb 201092 patients
Phase 3Completed

Dabigatran Etexilate Compared With Enoxaparin in Prevention of Venous Thromboembolism (VTE) Following Total Hip Arthroplasty

Start: Mar 20082,055 patients
Phase 3Completed
NCT00558259Boehringer Ingelheimdabigatran etexilate 150 mg twice daily

Twice-daily Oral Direct Thrombin Inhibitor Dabigatran Etexilate in the Long Term Prevention of Recurrent Symptomatic VTE

Start: Nov 20071,353 patients
Phase 3Completed
NCT00493896GSKFondaparinux

Safety of Fondaparinux as Routine VTE Prophylaxis in Medical ICU Patients

Start: Jul 2007Est. completion: Apr 201027 patients
Phase 3Terminated
NCT00333021GSKFondaparinux sodium

Abdominal Surgery Study Of GSK576428 (Fondaparinux Sodium)In Japanese Patients

Start: May 2006Est. completion: Feb 2007127 patients
Phase 3Completed

Dalteparin Low Molecular Weight Heparin for Primary Prophylaxis of Venous Thromboembolism in Brain Tumour Patients

Start: Oct 2002Est. completion: Nov 2006512 patients
Phase 3Completed

Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement Surgery

Start: May 2009Est. completion: Jan 2010369 patients
Phase 2/3Completed

Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Hip Replacement Surgery

Start: May 2009Est. completion: Mar 2010610 patients
Phase 2/3Completed

A Study Evaluating Efficacy and Safety of YM150 Compared to Enoxaparin in Subjects Undergoing Hip Replacement Surgery

Start: Apr 2009Est. completion: Aug 20101,992 patients
Phase 2/3Completed
NCT00531843GSKfondaparinux sodium

The Use of Fondaparinux in Preventing Thromboembolism in High Risk Trauma Patients

Start: Dec 2007Est. completion: Jun 2008105 patients
Phase 2/3Completed

Dose Ranging Study in Elective Total Hip Replacement Surgery

Start: May 2006Est. completion: May 20071,090 patients
Phase 2/3Completed

A Study to Compare the Efficacy and Safety of SRSD107 and Enoxaparin in Adult Subjects Undergoing TKA

Start: Sep 2025Est. completion: Oct 2026450 patients
Phase 2Recruiting

A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)

Start: Sep 2024Est. completion: Mar 2026195 patients
Phase 2Completed

A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants

Start: Jun 2024Est. completion: Jan 2025179 patients
Phase 2Completed

A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants

Start: May 2023Est. completion: May 2024373 patients
Phase 2Completed
NCT05189002PharmaDiallDimolegin 40 mg

A Study to Evaluate Dimolegin in Prevention of Thromboembolic Complications During Knee Replacement

Start: May 2019Est. completion: Dec 2022240 patients
Phase 2Unknown

Study to Assess the Safety and Efficacy of SelK2 to Prevent Blood Clots in Patients Undergoing Total Knee Replacement

Start: Feb 2019Est. completion: Nov 2019207 patients
Phase 2Completed

Tolerability , PK/PD and Safety of Dabigatran Etexilate Oral Liquid Formulation in Children < 1 Year of Age

Start: Sep 2014Est. completion: Feb 20168 patients
Phase 2Completed

Pharmacokinetics, Safety and Tolerability of Dabigatran Etexilate Solution in Children 1 to < 2 Years of Age

Start: Jan 2013Est. completion: Dec 20150
Phase 2Withdrawn

Active Comparator-Controlled Study to Assess Safety and Efficacy of ISIS-FXIRx in Total Knee Arthroplasty

Start: Oct 2012Est. completion: Aug 2014315 patients
Phase 2Completed

Safety and Tolerability of Dabigatran Etexilate Solution in Children 1 to < 12 Years of Age

Start: Mar 2010Est. completion: Feb 201618 patients
Phase 2Completed

Fragmin for the Treatment of Acute VTE in Pediatric Cancer Patients

Start: Aug 2009Est. completion: Mar 201838 patients
Phase 2Completed

Safety and Tolerability of Dabigatran Etexilate in Adolescents

Start: Jun 20099 patients
Phase 2Completed

A Phase 2b Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Hip Arthroplasty

Start: Jul 2008Est. completion: Jun 2009264 patients
Phase 2Completed

Efficacy and Safety of TAK-442 in Subjects Undergoing Total Knee Replacement

Start: Oct 2007Est. completion: Oct 20081,045 patients
Phase 2Completed

Phase IIa Venous Thromboembolism (VTE) Prevention Study In Total Knee Replacement (TKR)

Start: Feb 20070
Phase 2Withdrawn

A Phase 2b Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty

Start: Jul 2006Est. completion: Jul 2008523 patients
Phase 2Completed

Tinzaparin for Primary Treatment and Extended Secondary Prophylaxis of Venous Thromboembolism in Patients With Cancer

Start: Jul 2005Est. completion: Oct 2015131 patients
Phase 2Terminated

Factor IX Inhibition in Thrombosis Prevention (The FIXIT Trial)

Start: Jan 2005Est. completion: Apr 2006300 patients
Phase 2Completed

Hexadecasaccharide (SR123781A) in Patients With Unstable Angina or Non-ST-Segment Elevation Myocardial Infarction

Start: Dec 2004Est. completion: May 20071,257 patients
Phase 2Completed

Related Jobs

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

13 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 28,517 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.