Skip to main content

Venous Thromboembolism

33
Pipeline Programs
30
Companies
50
Clinical Trials
2 recruiting
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
6
4
13
8
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
4100%
+ 86 programs with unclassified modality

On Market (3)

Approved therapies currently available

Bristol Myers Squibb
ELIQUISApproved
apixaban
Bristol Myers Squibb
oral2025
18.3B Part D
Johnson & Johnson
XARELTOApproved
rivaroxaban
Johnson & Johnson
Factor Xa Inhibitor [EPC]oral2021
Bristol Myers Squibb
ELIQUIS SPRINKLEApproved
apixaban
Bristol Myers Squibb
oral2025

Competitive Landscape

29 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
10 programs
1
1
1
2
ApixabanPhase 4
DalteparinPhase 41 trial
dalteparinPhase 31 trial
dalteparinPhase 21 trial
ApixabanPhase 1
+5 more programs
Active Trials
NCT04969653Completed754,745Est. Jul 2023
NCT01046903Completed503Est. Feb 2011
NCT05022563Completed55,759Est. Sep 2021
+3 more trials
Bristol Myers Squibb
7 programs
1
ApixabanN/A1 trial
Eliquis (VTE Treatment and Prevention of Recurrent VTE) rPMSN/A1 trial
Non-InterventionalN/A1 trial
ApixabanPHASE_11 trial
Apixaban alonePHASE_11 trial
+2 more programs
Active Trials
NCT01885585Completed100Est. May 2015
NCT02546817Completed29Est. Sep 2017
NCT03087474Completed89,383Est. Jun 2018
+4 more trials
ViiV Healthcare
ViiV HealthcareNC - Durham
5 programs
1
1
2
1
FondaparinuxPhase 4
FondaparinuxPhase 3
Fondaparinux sodiumPhase 3
fondaparinux sodiumPhase 2/3
GW813893Phase 2
Leo Pharma
Leo PharmaDenmark - Ballerup
4 programs
1
2
TinzaparinPhase 41 trial
tinzaparinPhase 41 trial
WarfarinPhase 31 trial
TinzaparinN/A1 trial
Active Trials
NCT03099031Completed420Est. May 2017
NCT01130025Completed900Est. May 2014
NCT00851864Completed13Est. May 2011
+1 more trials
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
2 programs
1
XARELTO(Rivaroxaban)PHASE_3
XARELTO(Rivaroxaban)PHASE_3
Astellas
AstellasChina - Shenyang
7 programs
3
4
YM150Phase 31 trial
YM150Phase 31 trial
YM150Phase 31 trial
YM150Phase 31 trial
YM150Phase 2/31 trial
+2 more programs
Active Trials
NCT00902928Completed1,992Est. Aug 2010
NCT00917254Completed369Est. Jan 2010
NCT00913120Completed610Est. Mar 2010
+4 more trials
Anthos Therapeutics
2
AbelacimabPhase 3Monoclonal Antibody
AbelacimabPhase 3Monoclonal Antibody
Sandoz
SandozAustria - Kundl
2 programs
2
AbelacimabPhase 3Monoclonal Antibody
AbelacimabPhase 3Monoclonal Antibody
Quercis Pharma
Quercis PharmaSwitzerland - Zug
1 program
1
Kinisoquin™Phase 31 trial
Active Trials
NCT06861088Recruiting480Est. Oct 2029
PharmaDiall
PharmaDiallRussia - Moscow
1 program
1
Dimolegin 40 mgPhase 21 trial
Active Trials
NCT05189002Unknown240Est. Dec 2022
Sirius Therapeutics
Sirius TherapeuticsCA - San Diego
1 program
1
SRSD107Phase 21 trial
Active Trials
NCT07140523Recruiting450Est. Oct 2026
Tetherex Pharmaceuticals
Tetherex PharmaceuticalsOK - Oklahoma City
1 program
1
SelK2Phase 21 trial
Active Trials
NCT03812328Completed207Est. Nov 2019
vTv Therapeutics
vTv TherapeuticsNC - High Point
1 program
1
TTP889Phase 21 trial
Active Trials
NCT00119457Completed300Est. Apr 2006
Ono Pharmaceutical
Ono PharmaceuticalJapan - Osaka
1 program
1
ONO-7684Phase 11 trial
Active Trials
NCT03919890Completed72Est. Aug 2019
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
14 programs
Dabigatran EtexilateN/A1 trial
RE-COVERY DVT/PE: Global Study on Treatment Secondary Prevention of Acute Venous ThromboembolismN/A1 trial
dabigatranN/A1 trial
BIBR 1048PHASE_21 trial
BIBR 1048 capsulePHASE_21 trial
+9 more programs
Active Trials
NCT05536791Withdrawn0Est. Oct 2024
NCT02596230Completed7,797Est. Mar 2019
NCT01153698Terminated167Est. Dec 2011
+11 more trials
Daiichi Sankyo
Daiichi SankyoChina - Shanghai
8 programs
EdoxabanN/A1 trial
EdoxabanN/A1 trial
DU-176bPHASE_21 trial
DU-176b 15mgPHASE_21 trial
15mg DU-176bPHASE_31 trial
+3 more programs
Active Trials
NCT02943993Completed2,809Est. Dec 2020
NCT02952599Completed352Est. Oct 2019
NCT01203072Completed523Est. Jul 2008
+5 more trials
GSK
GSKLONDON, United Kingdom
5 programs
GW813893PHASE_21 trial
fondaparinux sodiumPHASE_2_31 trial
FondaparinuxPHASE_31 trial
Fondaparinux sodiumPHASE_31 trial
FondaparinuxPHASE_41 trial
Active Trials
NCT00541320Withdrawn0
NCT00531843Completed105Est. Jun 2008
NCT00493896Terminated27Est. Apr 2010
+2 more trials
Regeneron
RegeneronTARRYTOWN, NY
3 programs
REGN7508PHASE_21 trial
REGN9933PHASE_21 trial
REGN9933PHASE_21 trial
Active Trials
NCT06454630Completed179Est. Jan 2025
NCT06299111Completed195Est. Mar 2026
NCT05618808Completed373Est. May 2024
Inari Medical
Inari MedicalCA - Irvine
2 programs
ClotTriever SystemN/A1 trial
Percutaneous mechanical thrombectomyN/A1 trial
Active Trials
NCT05701917Recruiting300Est. Jan 2027
NCT06495996Completed66Est. Nov 2025
Eisai
EisaiChina - Liaoning
2 programs
Dalteparin sodiumN/A1 trial
dalteparin injectionPHASE_31 trial
Active Trials
NCT01050153Completed50Est. Dec 2011
NCT00876915Terminated218Est. Dec 2014
Sanofi
SanofiPARIS, France
2 programs
Epidemiology of Venous ThromboembolismN/A1 trial
SR123781APHASE_2_32 trials
Active Trials
NCT00456196Completed5,451Est. Jun 2009
NCT00338897Completed1,090Est. May 2007
NCT00123565Completed1,257Est. May 2007
Bayer
BayerLEVERKUSEN, Germany
2 programs
Global Anticoagulant Registry in the FIELD- Venous Thromboembolic EventsN/A1 trial
Use of Oral Contraceptives (OCs) Containing Dienogest and Risk of Venous ThromboembolismN/A1 trial
Active Trials
NCT02155491Completed10,679Est. Sep 2020
NCT00523614Completed3,400Est. Jun 2008
Medtronic
MedtronicNJ - Phillipsburg
1 program
SCDN/A1 trial
Active Trials
NCT03044574Completed407Est. Dec 2018
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
VTE Prophylaxis Guidelines in Hospitalized EldersN/A1 trial
Active Trials
NCT03025100CompletedEst. Mar 2017
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
blood testsN/A1 trial
Active Trials
NCT01608919Terminated4Est. Jan 2014
Ionis Pharmaceuticals
1 program
ISIS-FXIRx Dose #2PHASE_21 trial
Active Trials
NCT01713361Completed315Est. Aug 2014
Takeda
TakedaTOKYO, Japan
1 program
TAK-442PHASE_21 trial
Active Trials
NCT00641732Completed1,045Est. Oct 2008
Hamilton medical
Hamilton medicalSwitzerland - Bonaduz
1 program
Anti-Embolism Graduated Pressure StockingsPHASE_31 trial
Active Trials
NCT01234064Completed50Est. Dec 2011
Huadong Medicine
Huadong MedicineChina - Hangzhou
1 program
RivaroxabanPHASE_31 trial
Active Trials
NCT04066764Unknown200Est. Oct 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
GSKFondaparinux
Leo PharmaTinzaparin
PfizerDalteparin
Leo Pharmatinzaparin
Quercis PharmaKinisoquin™
Huadong MedicineRivaroxaban
Bristol Myers SquibbDebriefing and educative components
Boehringer Ingelheimdabigatran etexilate
Boehringer Ingelheimdabigatran etexilate
Daiichi Sankyo15mg DU-176b
Hamilton medicalAnti-Embolism Graduated Pressure Stockings
Leo PharmaWarfarin
Daiichi Sankyoedoxaban tosylate
Eisaidalteparin injection
AstellasYM150

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 28,190 patients across 50 trials

NCT01467583GSKFondaparinux

Fondaparinux in Critically Ill Patients With Renal Failure

Start: Nov 2011Est. completion: Nov 201332 patients
Phase 4Completed

Safety and Efficacy of Therapeutic Anticoagulation With Tinzaparin During Pregnancy Via Weight-based Dosing

Start: Oct 2007Est. completion: May 201113 patients
Phase 4Completed

Dalteparin vs Unfractionated Heparin For The Prevention Of Venous Thromboembolism (VTE) In Hospitalized Acutely Ill Medical Patients

Start: Jun 2007Est. completion: Jul 200884 patients
Phase 4Terminated

Long-Term Low-Molecular-Weight Heparin Versus Oral Anticoagulants in Deep Venous Thrombosis

Start: Jan 2002Est. completion: Jan 2005241 patients
Phase 4Completed

The Effect of Kinisoquin™ on Thromboembolic Events in Patients With Metastatic or Locally Advanced Pancreatic Cancer

Start: Dec 2025Est. completion: Oct 2029480 patients
Phase 3Recruiting

Rivaroxaban and Vitamin K Antagonists for the Anticoagulation for the Implantation of Vena Cava Filters

Start: May 2020Est. completion: Oct 2024200 patients
Phase 3Unknown
NCT04141254Bristol Myers SquibbDebriefing and educative components

Impact of Early Debriefing and Enhanced Educative Components on Direct Oral Anticoagulant Adherence After Venous Thromboembolism.

Start: Dec 2019Est. completion: Dec 2021150 patients
Phase 3Unknown

Safety of Dabigatran Etexilate in Blood Clot Prevention in Children

Start: Sep 2014Est. completion: Nov 2019214 patients
Phase 3Completed

Open Label Study Comparing Efficacy and Safety of Dabigatran Etexilate to Standard of Care in Paediatric Patients With Venous Thromboembolism (VTE)

Start: Sep 2013Est. completion: Nov 2019267 patients
Phase 3Completed

Safety and Pharmacokinetics Study of DU-176b Administered to Patients With Severe Renal Impairment Undergoing Orthopedic Surgery of The Lower Limbs

Start: Mar 2012Est. completion: Dec 201280 patients
Phase 3Completed
NCT01234064Hamilton medicalAnti-Embolism Graduated Pressure Stockings

Graduated Compression Stockings (GCS) Pilot Substudy

Start: Nov 2010Est. completion: Dec 201150 patients
Phase 3Completed

Long-Term Innohep® Treatment Versus a Vitamin K Antagonist (Warfarin) for the Treatment of Venous Thromboembolism (VTE) in Cancer

Start: Aug 2010Est. completion: May 2014900 patients
Phase 3Completed
NCT00986154Daiichi Sankyoedoxaban tosylate

Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots. (The Edoxaban Hokusai-VTE Study).

Start: Oct 2009Est. completion: Apr 20138,292 patients
Phase 3Completed
NCT00876915Eisaidalteparin injection

A Study of Dalteparin Prophylaxis in High-Risk Ambulatory Cancer Patients

Start: Jul 2009Est. completion: Dec 2014218 patients
Phase 3Terminated

Prevention of Venous Thromboembolism in Subjects Undergoing Hip Fracture Surgery or Surgery in the Lower Extremities

Start: Jun 2009Est. completion: Apr 2010101 patients
Phase 3Completed

Prevention of Recurrence of Venous Thromboembolism in Patients With a History of Venous Thromboembolism

Start: Jun 2009Est. completion: Dec 201087 patients
Phase 3Completed

A Study to Assess the Effect of YM150 for Prevention of Venous Thromboembolism in Patients Undergoing Major Abdominal Surgery

Start: Jun 2009Est. completion: Apr 2010156 patients
Phase 3Completed

YM150 for Prevention of Venous Thromboembolism in Patients With Acute Medical Illness

Start: May 2009Est. completion: Apr 201052 patients
Phase 3Completed

A Phase 3 Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty

Start: Mar 2009Est. completion: Feb 2010716 patients
Phase 3Completed

Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Hip Fracture Surgery

Start: Oct 2008Est. completion: Feb 201092 patients
Phase 3Completed

Dabigatran Etexilate Compared With Enoxaparin in Prevention of Venous Thromboembolism (VTE) Following Total Hip Arthroplasty

Start: Mar 20082,055 patients
Phase 3Completed
NCT00558259Boehringer Ingelheimdabigatran etexilate 150 mg twice daily

Twice-daily Oral Direct Thrombin Inhibitor Dabigatran Etexilate in the Long Term Prevention of Recurrent Symptomatic VTE

Start: Nov 20071,353 patients
Phase 3Completed
NCT00493896GSKFondaparinux

Safety of Fondaparinux as Routine VTE Prophylaxis in Medical ICU Patients

Start: Jul 2007Est. completion: Apr 201027 patients
Phase 3Terminated
NCT00333021GSKFondaparinux sodium

Abdominal Surgery Study Of GSK576428 (Fondaparinux Sodium)In Japanese Patients

Start: May 2006Est. completion: Feb 2007127 patients
Phase 3Completed

Dalteparin Low Molecular Weight Heparin for Primary Prophylaxis of Venous Thromboembolism in Brain Tumour Patients

Start: Oct 2002Est. completion: Nov 2006512 patients
Phase 3Completed

Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement Surgery

Start: May 2009Est. completion: Jan 2010369 patients
Phase 2/3Completed

Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Hip Replacement Surgery

Start: May 2009Est. completion: Mar 2010610 patients
Phase 2/3Completed

A Study Evaluating Efficacy and Safety of YM150 Compared to Enoxaparin in Subjects Undergoing Hip Replacement Surgery

Start: Apr 2009Est. completion: Aug 20101,992 patients
Phase 2/3Completed
NCT00531843GSKfondaparinux sodium

The Use of Fondaparinux in Preventing Thromboembolism in High Risk Trauma Patients

Start: Dec 2007Est. completion: Jun 2008105 patients
Phase 2/3Completed

Dose Ranging Study in Elective Total Hip Replacement Surgery

Start: May 2006Est. completion: May 20071,090 patients
Phase 2/3Completed

A Study to Compare the Efficacy and Safety of SRSD107 and Enoxaparin in Adult Subjects Undergoing TKA

Start: Sep 2025Est. completion: Oct 2026450 patients
Phase 2Recruiting

A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)

Start: Sep 2024Est. completion: Mar 2026195 patients
Phase 2Completed

A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants

Start: Jun 2024Est. completion: Jan 2025179 patients
Phase 2Completed

A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants

Start: May 2023Est. completion: May 2024373 patients
Phase 2Completed
NCT05189002PharmaDiallDimolegin 40 mg

A Study to Evaluate Dimolegin in Prevention of Thromboembolic Complications During Knee Replacement

Start: May 2019Est. completion: Dec 2022240 patients
Phase 2Unknown

Study to Assess the Safety and Efficacy of SelK2 to Prevent Blood Clots in Patients Undergoing Total Knee Replacement

Start: Feb 2019Est. completion: Nov 2019207 patients
Phase 2Completed

Tolerability , PK/PD and Safety of Dabigatran Etexilate Oral Liquid Formulation in Children < 1 Year of Age

Start: Sep 2014Est. completion: Feb 20168 patients
Phase 2Completed

Pharmacokinetics, Safety and Tolerability of Dabigatran Etexilate Solution in Children 1 to < 2 Years of Age

Start: Jan 2013Est. completion: Dec 20150
Phase 2Withdrawn

Active Comparator-Controlled Study to Assess Safety and Efficacy of ISIS-FXIRx in Total Knee Arthroplasty

Start: Oct 2012Est. completion: Aug 2014315 patients
Phase 2Completed

Safety and Tolerability of Dabigatran Etexilate Solution in Children 1 to < 12 Years of Age

Start: Mar 2010Est. completion: Feb 201618 patients
Phase 2Completed

Fragmin for the Treatment of Acute VTE in Pediatric Cancer Patients

Start: Aug 2009Est. completion: Mar 201838 patients
Phase 2Completed

Safety and Tolerability of Dabigatran Etexilate in Adolescents

Start: Jun 20099 patients
Phase 2Completed

A Phase 2b Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Hip Arthroplasty

Start: Jul 2008Est. completion: Jun 2009264 patients
Phase 2Completed

Efficacy and Safety of TAK-442 in Subjects Undergoing Total Knee Replacement

Start: Oct 2007Est. completion: Oct 20081,045 patients
Phase 2Completed

Phase IIa Venous Thromboembolism (VTE) Prevention Study In Total Knee Replacement (TKR)

Start: Feb 20070
Phase 2Withdrawn

A Phase 2b Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty

Start: Jul 2006Est. completion: Jul 2008523 patients
Phase 2Completed

Tinzaparin for Primary Treatment and Extended Secondary Prophylaxis of Venous Thromboembolism in Patients With Cancer

Start: Jul 2005Est. completion: Oct 2015131 patients
Phase 2Terminated

Factor IX Inhibition in Thrombosis Prevention (The FIXIT Trial)

Start: Jan 2005Est. completion: Apr 2006300 patients
Phase 2Completed

Hexadecasaccharide (SR123781A) in Patients With Unstable Angina or Non-ST-Segment Elevation Myocardial Infarction

Start: Dec 2004Est. completion: May 20071,257 patients
Phase 2Completed

BIBR 1048 Dose Range Finding Study in Prevention of Venous Thromboembolism in Patients With Primary Elective Total Hip or Knee Replacement Surgery

Start: Nov 20021,973 patients
Phase 2Completed

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

13 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 28,190 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.