Gedeon Richter

Gedeon Richter

Hungary - Budapest
Biotechnology
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Focus: Small Molecules, Generics

Gedeon Richter is a life sciences company focused on Small Molecules, Generics.

NeurologyCardiovascularMetabolic DiseasesImmunology
Funding Stage
PUBLIC
Employees
1001-5000
Open Jobs
0

Products & Portfolio (4)

AMLODIPINE BESYLATE
amlodipine besylate
Pre-Launch
ORAL · TABLET
(calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects can be detected in vitro but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa=8.6), and its kinetic interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. The precise mechanisms by which amlodipine relieves angina have not been fully delineated, but are thought to include the following: Exertional Angina: In patients with exertional angina, amlodipine reduces the total peripheral resistance (afterload) against which the heart works and reduces the rate pressure product, and thus myocardial oxygen demand, at any given level of exercise. Vasospastic Angina: Amlodipine has been demonstrated to block constriction and restore blood flow in coronary arteries and arterioles in response to calcium, potassium epinephrine, serotonin, and thromboxane A2 analog in experimental animal models and in human coronary vessels in vitro . This inhibition of coronary spasm is responsible for the effectiveness of amlodipine in vasospastic (Prinzmetal's or variant) angina.
hypertensionto lower blood pressureconfirmed+4 more
FINASTERIDE
finasteride
Post-LOE
ORAL · TABLET
2006
30
FLUCONAZOLE
fluconazole
Pre-Launch
SMORAL · TABLET
TERBINAFINE HYDROCHLORIDE
terbinafine hydrochloride
Pre-Launch
ORAL · TABLET

Pipeline & Clinical Trials

Retrospective data collection
Fertility Disorders
N/A
Clinical Trials (1)
NCT05271981Fertility After Uterine Artery Embolization
N/A
ULIPRISTAL ACETATE
Infertility, Female
N/A
Clinical Trials (1)
NCT03349190Impact of Esmya on Fertility to Infertile Women With Fibroids Managed With Assisted Reproduction Techniques
N/A
International Active Surveillance Study: Safety of Estrogen Estetrol (E4) Contraceptive Study (INAS-
Contraception
N/A
Clinical Trials (1)
NCT06186271International Active Surveillance Study: Safety of Estrogen Estetrol (E4) Contraceptive Study (INAS-SEECS)
N/A
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
Pre-eclampsia
N/A
Clinical Trials (1)
NCT07263490PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
N/A
European Active Surveillance Study Comparing Regimens of Administration in Combined Hormonal Contrac
Contraception
N/A
Clinical Trials (1)
NCT02577913European Active Surveillance Study Comparing Regimens of Administration in Combined Hormonal Contraception
N/A
Vaginal progesterone soft capsules
Frozen Embryo Transfer (FET)
N/A
Clinical Trials (1)
NCT07461909Comparison of Two Vaginal Progesterone Forms in Frozen Embryo Transfer
N/A
International Active Surveillance Study: Native Estrogen Estetrol (E4) Safety Study
Contraception
N/A
Clinical Trials (1)
NCT06028555International Active Surveillance Study: Native Estrogen Estetrol (E4) Safety Study
N/A
Chinese Assessment for Vinpocetine In Neurology
Cerebral Infarction
N/A
Clinical Trials (1)
NCT01400035Chinese Assessment for Vinpocetine In Neurology
N/A
Globifer Forte
Iron Deficiency
N/A
Clinical Trials (1)
NCT03055559Trial Protocol GlobiFer - Oral Iron Repletion
N/A
Natural proliferative phase frozen embryo transfer
Frozen Embryo Transfer
N/A
Clinical Trials (1)
NCT06307184Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer
N/A
Cariprazine prolonged release tablet A
Pharmacokinetic Profile
Phase 1
Clinical Trials (1)
NCT02165098Cariprazine: Comparison of Slow- and Immediate-release Forms
Phase 1
Phase 1
Clinical Trials (1)
NCT05738850Study to Assess Adverse Events and How ABBV-932 Oral Capsules Moves Through the Body of Healthy Adult Participants
Phase 1
Empagliflozin + Metformin hydrochloride 5 mg/850 mg combination film-coated tablets
Diabetes Mellitus Type 2
Phase 1
Clinical Trials (1)
NCT06766500Pharmacokinetics and Bioequivalence Study of Empagliflozin+Metformin Hydrochloride 5 mg/850 mg Film-coated Tablets (Gedeon Richter Plc., Hungary) Versus Synjardy® 5 mg/850 mg Film-coated Tablets (Boehringer Ingelheim International GmbH, Germany)
Phase 1
RGB-02 or Neulasta®
Bioequivalence
Phase 1
Clinical Trials (1)
NCT03146988Study to Compare the Pharmacokinetics and Pharmacodynamics of 6 mg RGB-02 to 6 mg Neulasta
Phase 1
Azilsartan medoxomil 80 mg tablet
Hypertension
Phase 1
Clinical Trials (1)
NCT06990204Bioequivalence Study of Azilsartan Medoxomil 80 mg Tablets (Gedeon Richter Plc., Hungary) and Edarbi® 80 mg Tablets (JSC Nizhpharm, Russia)
Phase 1
Empagliflozin + Metformin hydrochloride 5 mg/1000 mg combination film-coated tablets
Diabetes Mellitus Type 2
Phase 1
Clinical Trials (1)
NCT06792968Pharmacokinetics and Bioequivalence Study of Empagliflozin+Metformin Hydrochloride 5 mg/1000 mg Film-coated Tablets (Gedeon Richter Plc., Hungary) Versus Synjardy 5 mg/1000 mg Film-coated Tablets (Boehringer Ingelheim International GmbH, Germany)
Phase 1
Phase 1
Clinical Trials (1)
NCT02001584A Study to Examine the, Safety, Tolerability and Pharmacokinetics Co-Administered Baclofen and Memantine in Obese and Lean, Otherwise Healthy Adults
Phase 1
Empagliflozin + Metformin hydrochloride 12.5 mg/1000 mg combination film-coated tablets
Diabetes Mellitus Type 2
Phase 1
Clinical Trials (1)
NCT06823856Pharmacokinetics and Bioequivalence Study of Empagliflozin+Metformin Hydrochloride 12.5 mg/1000 mg Film-coated Tablets (Gedeon Richter Plc., Hungary) Versus Synjardy 12.5 mg/1000 mg Film-coated Tablets (Boehringer Ingelheim International GmbH, Germany)
Phase 1
RGB-10
Healthy
Phase 1
Clinical Trials (1)
NCT02223416A Study Aimed at Assessing the Pharmacokinetic Properties of RGB-10 and Forsteo
Phase 1
Phase 1
Clinical Trials (1)
NCT02371096Comparative Pharmacokinetic Trial of RGB-03 and MabThera
Phase 1
Letrozole 5 mg
IVF
Phase 2
Clinical Trials (1)
NCT04524026RIOTC: Reducing the Impact of Ovarian Stimulation. Novel Approaches to Luteal Support in IVF-Study 2
Phase 2
Cariprazine
Bipolar Disorder
Phase 2
Clinical Trials (1)
NCT00488618Study Evaluating Cariprazine (RGH-188) in the Treatment of Patients With Acute Mania
Phase 2
Phase 2
Clinical Trials (1)
NCT01469377Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disorder
Phase 2
Cariprazine
Schizophrenia
Phase 2
Clinical Trials (1)
NCT00839852A Study of Cariprazine in Patients With Chronic Stable Schizophrenia
Phase 2
Antidepressant + placebo
Major Depressive Disorder
Phase 2
Clinical Trials (1)
NCT00854100Safety and Efficacy of Cariprazine As Adjunctive Therapy In Major Depressive Disorder
Phase 2
Phase 2
Clinical Trials (1)
NCT01396447Safety, Tolerability, and Efficacy of Cariprazine in Participants With Bipolar Depression
Phase 2
Phase 2
Clinical Trials (1)
NCT05322096Study to Evaluate Efficacy, Safety, and Tolerability of RGH-706 in Prader-Willi Syndrome
Phase 2
Phase 2
Clinical Trials (1)
NCT00694707Safety and Efficacy of Cariprazine (RGH-188) in the Acute Exacerbation of Schizophrenia
Phase 2
Phase 2
Clinical Trials (1)
NCT00838799Study of the Safety and Efficacy of RGH-896 in Patients With Diabetic Peripheral Neuropathic Pain
Phase 2
Phase 2
Clinical Trials (1)
NCT00852202Safety and Efficacy of RGH-188 (Cariprazine) in Bipolar Depression
Phase 2
Ulipristal acetate
Adenomyosis
Phase 2
Clinical Trials (1)
NCT02587000Adenomyosis and Ulipristal Acetate
Phase 2
Phase 3
Clinical Trials (1)
NCT01838876Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disorder
Phase 3
Phase 3
Clinical Trials (1)
NCT05087030Comparative Efficacy and Safety Study of RGB-14-P and Prolia® in Women With Postmenopausal Osteoporosis
Phase 3
Cariprazine
Bipolar Disorder
Phase 3
Clinical Trials (1)
NCT01058096Safety and Efficacy of Cariprazine for Mania
Phase 3
Cariprazine
Mania
Phase 3
Clinical Trials (1)
NCT01058668Safety and Efficacy of Cariprazine for Bipolar I Disorder
Phase 3
Phase 3
Clinical Trials (1)
NCT01412060A Study of Cariprazine in the Prevention of Relapse of Symptoms in Participants With Schizophrenia
Phase 3
Phase 3
Clinical Trials (1)
NCT01715805Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD)
Phase 3
Cariprazine
Schizophrenia
Phase 3
Clinical Trials (1)
NCT03817502Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia
Phase 3
Cariprazine
Schizophrenia
Phase 3
Clinical Trials (1)
NCT01104779Safety and Efficacy of Cariprazine in Schizophrenia
Phase 3
Phase 3
Clinical Trials (1)
NCT01059539Long-term Safety and Tolerability of Cariprazine for Bipolar I Disorder
Phase 3
Cariprazine
Schizophrenia
Phase 3
Clinical Trials (1)
NCT01104792Long-term Study of Cariprazine in Patients With Schizophrenia
Phase 3
Cariprazine
Schizophrenia
Phase 3
Clinical Trials (1)
NCT01104766Safety and Efficacy of Cariprazine in Patients With Schizophrenia
Phase 3
Phase 4
Clinical Trials (1)
NCT04306692Myo-inositol Versus Clomiphene Citrate in PCOS
Phase 4
spironolactone
Hypertension
Phase 4
Clinical Trials (1)
NCT00524615Addition of Spironolactone in Patients With Resistant Arterial Hypertension
Phase 4

Open Jobs (0)

No open positions listed yet. Check their careers page directly.

Interview Prep Quick Facts
Founded: 1901
Portfolio: 4 approved products, 44 clinical trials
Top TAs: Neurology, Cardiovascular, Metabolic Diseases
Publications: 25 in PubMed
Portfolio Health
Pre-Launch3 (75%)
Post-LOE1 (25%)
4 total products
Therapeutic Area Focus
Neurology
15 pipeline
Cardiovascular
1 marketed3 pipeline
Women's Health
3 pipeline
Immunology
1 pipeline
Marketed
Pipeline