Contraception

126

Pipeline Programs

Companies

Clinical Trials

2 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule

1100%

+ 218 programs with unclassified modality

On Market (10)

Approved therapies currently available

MIRENAApproved

levonorgestrel

Bayer

Progestin [EPC]intrauterine2000

777K Part D

KYLEENAApproved

levonorgestrel

Bayer

Progestin [EPC]intrauterine2016

49K Part D

SKYLAApproved

levonorgestrel

Bayer

Progestin [EPC]intrauterine2013

13K Part D

LEVONORGESTRELApproved

levonorgestrel

Teva

oral2014

NORPLANT SYSTEM IN PLASTIC CONTAINERApproved

levonorgestrel

Pfizer

implantation1990

HER STYLEApproved

levonorgestrel

Teva

Progestin [EPC]oral2016

TWIRLAApproved

levonorgestrel/ethinyl estradiol

Agile Therapeutics

Estrogen [EPC]transdermal2020

PLAN B ONE-STEPApproved

levonorgestrel

Teva

Progestin [EPC]oral2009

FALLBACK SOLOApproved

levonorgestrel

Teva

Progestin [EPC]oral2014

PLAN BApproved

levonorgestrel

Teva

oral1999

Competitive Landscape

33 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

BayerLEVERKUSEN, Germany

89 programs

EE20/DRSPPhase 41 trial

LevonorgestrelPhase 41 trial

Long Acting Reversible ContraceptionPhase 4

MirenaPhase 41 trial

+84 more programs

Active Trials

NCT02159261Completed1,500Est. Aug 2016

NCT03127722Completed990Est. Dec 2024

NCT00302848Completed59,510Est. Dec 2005

+85 more trials

Human BioSciencesWV - Martinsburg

26 programs

Desogestrel / Ethinyl Estradiol PillPhase 41 trial

Individualized InterventionPhase 41 trial

MiglustatPhase 4Small Molecule1 trial

Ulipristal AcetatePhase 41 trial

emergency contraceptionPhase 41 trial

+21 more programs

Active Trials

NCT05240066Active Not Recruiting1,341Est. Jun 2026

NCT00065871Unknown250Est. Feb 2006

NCT05691270Terminated18Est. Jul 2024

+23 more trials

Oregon Therapeutics

16 programs

Cannabidiol OilPhase 41 trial

ECx1Phase 41 trial

Immediate IUD insertionPhase 41 trial

Levonorgestrel IUSPhase 41 trial

Long Acting Reversible ContraceptionPhase 4

+11 more programs

Active Trials

NCT05988983Active Not Recruiting1,026Est. Mar 2026

NCT03499379Completed39Est. Dec 2019

NCT02169869Terminated33Est. Jun 2017

+10 more trials

Colorado TherapeuticsCO - Louisville

11 programs

Desogestrel and Ethinyl Estradiol TabletsPhase 41 trial

Etonogestrel contraceptive implantPhase 4

Etonogestrel implantPhase 41 trial

Rifampin 600 MGPhase 4

+6 more programs

Active Trials

NCT03092037Completed900Est. Apr 2022

NCT01422226Terminated3Est. Aug 2012

NCT02067663Completed123Est. Sep 2015

+6 more trials

MSDIreland - Ballydine

9 programs

Etonogestrel contraceptive implantPhase 4

Long Acting Reversible ContraceptionPhase 4

Rifampin 600 MGPhase 4

ENG implantPhase 1

+4 more programs

Sharp TherapeuticsPA - Pittsburgh

9 programs

Etonogestrel contraceptive implantPhase 41 trial

Long Acting Reversible ContraceptionPhase 41 trial

Rifampin 600 MGPhase 41 trial

ENG implantPhase 11 trial

+4 more programs

Active Trials

NCT03058978Completed117Est. Dec 2021

NCT02037919Completed148Est. May 2017

NCT03559634Completed55Est. Jan 2023

+6 more trials

TevaIsrael - Petach Tikva

6 programs

Immediate postpartum placement of IUDN/A1 trial

TV-46046PHASE_11 trial

DR-1011PHASE_31 trial

DR-102PHASE_33 trials

+1 more programs

Active Trials

NCT02024672Completed96Est. Sep 2017

NCT04682353Completed60Est. Jan 2023

NCT03700658Completed27Est. Oct 2020

+5 more trials

PfizerNEW YORK, NY

6 programs

Depo-Provera Contraceptive Injection - DP150CIPhase 41 trial

Sayana PressPhase 41 trial

Subcutaneous depot medroxyprogesterone acetatePhase 41 trial

Levonorgestrel 90 mg/Ethinyl Estradiol 20 mgPhase 31 trial

Medroxyprogesterone 17-AcetateN/A1 trial

+1 more programs

Active Trials

NCT01019369Completed132Est. Nov 2012

NCT00775047Completed50Est. Jul 2008

NCT00245921Completed2,000Est. Oct 2005

+3 more trials

Agile TherapeuticsNJ - Princeton

4 programs

AG200-15Phase 31 trial

levonorgestrel and ethinyl estradiolPhase 31 trial

TWIRLA(levonorgestrel)Phase 21 trial

Active Trials

NCT01623466Completed36Est. Sep 2012

NCT01236768Completed407Est. Jun 2011

NCT01181479Completed1,504Est. Mar 2012

+1 more trials

Innovation PharmaceuticalsMA - Wakefield

1 program

Copper IUDPhase 41 trial

Active Trials

NCT00733278Completed7Est. Sep 2008

CooperSurgicalCT - Trumbull

1 program

Paragard® T380A Intrauterine Copper Contraceptive with New InserterPhase 41 trial

Active Trials

NCT05309694Completed119Est. Dec 2022

Sebela PharmaceuticalsGA - Roswell

3 programs

LevoCeptPhase 31 trial

LevoCeptPhase 21 trial

VeraCeptPhase 21 trial

Active Trials

NCT02882191Completed279Est. Nov 2020

NCT02446821Completed286Est. Mar 2019

NCT04457076Not Yet Recruiting1,525Est. Jun 2032

ViiV HealthcareNC - Durham

2 programs

Oral TestosteronePhase 2

Testosterone EnanthatePhase 1/2

Quotient TherapeuticsMA - Cambridge

2 programs

E4/DRSPPhase 11 trial

EstetrolPhase 11 trial

Active Trials

NCT03512860Completed24Est. Oct 2018

NCT02720224Completed6Est. Apr 2016

Biolab Pharma

1 program

Test formulationPhase 11 trial

Active Trials

NCT03443089Completed24Est. Aug 2017

KBioKY - Owensboro

1 program

ZB-06Phase 11 trial

Active Trials

NCT04731818Completed20Est. Feb 2022

Merck & Co.RAHWAY, NJ

9 programs

Etonogestrel ImplantN/A

Immediate Nexplanon InsertionN/A

Intervention GroupN/A

Track bleeding patterns before and after implantN/A

ENG implantPHASE_1

+4 more programs

FemasysSUWANEE, GA

4 programs

FemBlocN/A1 trial

FemBloc® Permanent Contraceptive SystemN/A1 trial

Active Trials

NCT03433911Completed240Est. Feb 2025

NCT04273594Active Not Recruiting45Est. Apr 2027

NCT05977751Recruiting573Est. Jun 2031

+1 more trials

Daré BioscienceCA - San Diego

2 programs

OvapreneN/A

Johnson & JohnsonNEW BRUNSWICK, NJ

2 programs

EVRA transdermal contraceptive patch 6 mg NGMN and 0.75 mg EEPHASE_11 trial

norelgestromin + ethinyl estradiolPHASE_34 trials

Active Trials

NCT00258076Completed53Est. Sep 2004

NCT00261482Completed778Est. Dec 2004

NCT00236769Completed1,751Est. Oct 1999

+2 more trials

ParexelMA - Boston

2 programs

AMPHORAPHASE_3

Ethinylestradiol/GestodenePHASE_3

Evofem BiosciencesCA - San Diego

2 programs

AMPHORAPHASE_31 trial

ConceptrolPHASE_31 trial

Active Trials

NCT03243305Completed1,384Est. Nov 2018

NCT01306331Completed3,389Est. Jun 2014

Alliance PharmaceuticalsUK - Wiltshire

1 program

Contraceptive app instant messagesN/A1 trial

Active Trials

NCT02905513Completed580Est. Nov 2017

Essential Pharmaceuticals

1 program

Control Latex Condom C, Polyurethane Condom A, Polyurethane Condom BN/A1 trial

Active Trials

NCT04622306Completed300Est. Dec 2021

Allergy TherapeuticsUK - West Sussex

1 program

Family Planning Knowledge, Attitudes, and Practices of Postpartum Malawian WomenN/A1 trial

Active Trials

NCT01893021Completed634Est. Oct 2014

Purdue PharmaCT - Stamford

1 program

HAPPI softwareN/A1 trial

Active Trials

NCT06823037Recruiting150Est. Aug 2026

Pathfinder PharmaceuticalsNC - Durham

1 program

Household VisitsN/A1 trial

Active Trials

NCT03226730Completed2,898Est. Mar 2021

Gedeon RichterHungary - Budapest

1 program

International Active Surveillance Study: Native Estrogen Estetrol (E4) Safety StudyN/A1 trial

Active Trials

NCT06028555Recruiting101,000Est. Oct 2028

Forte Biosciences

1 program

Quality Improvement CollaborativeN/A1 trial

Active Trials

NCT05521646Unknown4,000Est. Sep 2025

MediaPharmaItaly - Chieti

1 program

Radio Mass Media Family Planning CampaignN/A1 trial

Active Trials

NCT02714686Unknown7,515Est. May 2019

+3 more companies

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

Human BioSciencesDesogestrel / Ethinyl Estradiol Pill

Colorado TherapeuticsEtonogestrel implant

CooperSurgicalParagard® T380A Intrauterine Copper Contraceptive with New Inserter

Colorado TherapeuticsDesogestrel and Ethinyl Estradiol Tablets

Colorado TherapeuticsEtonogestrel implant

Sharp TherapeuticsRifampin 600 MG

Sharp TherapeuticsEtonogestrel contraceptive implant

Oregon TherapeuticsCannabidiol Oil

Human BioSciencesUlipristal Acetate

PfizerSayana Press

Sharp TherapeuticsEtonogestrel contraceptive implant

BayerLevonorgestrel

BayerEE20/DRSP

Sharp TherapeuticsLong Acting Reversible Contraception

Oregon TherapeuticsUlipristal Acetate

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 31,553 patients across 50 trials

NCT06334315 Human BioSciencesDesogestrel / Ethinyl Estradiol Pill

Oral Contraceptive Pill (OCP) Pharmacogenomics

Start: Oct 2024Est. completion: May 2028700 patients

Phase 4Recruiting

NCT05237141 Colorado TherapeuticsEtonogestrel implant

Etonogestrel Implant as Emergency Contraception

Start: Apr 2022Est. completion: Dec 202612 patients

Phase 4Recruiting

NCT05309694 CooperSurgicalParagard® T380A Intrauterine Copper Contraceptive with New Inserter

A Study to Assess the Safety of a New Inserter Device for Paragard® (Intrauterine Copper Contraceptive)

Start: Mar 2022Est. completion: Dec 2022119 patients

Phase 4Completed

NCT05002738 Colorado TherapeuticsDesogestrel and Ethinyl Estradiol Tablets

Desogestrel-containing COCP Pharmacokinetic Validation Study

Start: Sep 2021Est. completion: Nov 202222 patients

Phase 4Completed

NCT04463693 Colorado TherapeuticsEtonogestrel implant

Shoulder Contraceptive Implant Study

Start: Oct 2020Est. completion: Feb 20225 patients

Phase 4Completed

NCT04463680 Sharp TherapeuticsRifampin 600 MG

Rifampin and the Contraceptive Implant

Start: Sep 2020Est. completion: Feb 202224 patients

Phase 4Completed

NCT04423055 Sharp TherapeuticsEtonogestrel contraceptive implant

Nexplanon Use in Women Primarily Choosing a Combined Oral Contraceptive

Start: Aug 2020Est. completion: Apr 2024120 patients

Phase 4Completed

NCT04396730 Oregon TherapeuticsCannabidiol Oil

Cannabidiol and Oral Contraceptive Pills: Exploring a Drug-Drug Interaction

Start: Apr 2020Est. completion: Mar 20229 patients

Phase 4Completed

NCT03537768 Human BioSciencesUlipristal Acetate

Study Comparing Emergency Contraception Effectiveness in Women Who Weight ≥ 80 kg

Start: Jul 2018Est. completion: Apr 2022532 patients

Phase 4Terminated

NCT03034057 PfizerSayana Press

Sayana Press UK Self-Injection Study

Start: Aug 2017Est. completion: Dec 2018169 patients

Phase 4Completed

NCT02852265 Sharp TherapeuticsEtonogestrel contraceptive implant

Nexplanon and Combined Oral Contraceptive (COC) Combined Use Study

Start: Sep 2016Est. completion: Jul 201720 patients

Phase 4Completed

NCT02957292 BayerLevonorgestrel

A Study to Compare the Menstrual Bleeding Profile Among Jaydess® and Copper Intrauterine Device (IUD) Users. COLIBRI STUDY (Copper and Levonorgestrel IUD Barcelona Research Initiative).

Start: Jun 2016Est. completion: Sep 2020108 patients

Phase 4Completed

NCT02710708 BayerEE20/DRSP

YAZ Post Authorization Safety Study (PASS)/Post Authorization Efficacy Study (PAES) in China

Start: May 2016Est. completion: Jul 20181,921 patients

Phase 4Completed

NCT02735551 Sharp TherapeuticsLong Acting Reversible Contraception

LARC Forward Contraceptive Counseling at MHCC

Start: Apr 2016Est. completion: Mar 20173 patients

Phase 4Terminated

NCT02577601 Oregon TherapeuticsUlipristal Acetate

Impact of Combined Hormonal Contraceptives on UPA

Start: Sep 2015Est. completion: Jun 201736 patients

Phase 4Completed

NCT02509767 PfizerSubcutaneous depot medroxyprogesterone acetate

Depo Provera Self-Administration Study: Putting a Patient-Centered Practice to the Test at Planned Parenthood

Start: Aug 2015Est. completion: Dec 2017401 patients

Phase 4Completed

NCT02408692 Oregon TherapeuticsECx1

Emergency Contraception and Body Weight: Pilot Study

Start: Feb 2015Est. completion: Aug 201510 patients

Phase 4Completed

NCT01594476 Oregon TherapeuticsLevonorgestrel IUS

Early Postpartum Intrauterine Device (IUD) Placement

Start: Mar 2012Est. completion: Jul 2014201 patients

Phase 4Terminated

NCT00733278 Innovation PharmaceuticalsCopper IUD

Intrauterine Contraceptive Device (IUD) Placement at Time of C-Section

Start: Nov 2007Est. completion: Sep 20087 patients

Phase 4Completed

NCT00562276 Oregon TherapeuticsImmediate IUD insertion

Immediate Versus Delayed Intrauterine Device (IUD) Insertion Following First Trimester Suction Aspiration Procedures

Start: May 2007Est. completion: Jun 2009578 patients

Phase 4Completed

NCT00393198 BayerLevonorgestrel

Bleeding Pattern and User Satisfaction During Second Consecutive MIRENA® in Contraception and Treatment of Menorrhagia

Start: Oct 2006Est. completion: Oct 2012204 patients

Phase 4Completed

NCT00662454 Oregon Therapeuticsethinyl estradiol / levonorgestrel

Oral Contraceptive Efficacy and Body Weight

Start: Jan 2006Est. completion: May 2006120 patients

Phase 4Completed

NCT00498784 BayerMirena

HR-QoL and Sexuality in Mirena Inserted Contraception Users

Start: Nov 2005Est. completion: Oct 2007141 patients

Phase 4Completed

NCT00194649 Human BioSciencesMiglustat

Glycosphingolipid Inhibition and Spermatogenesis in Man: A Pilot Study (MIG 2)

Start: Jun 2005Est. completion: Jan 20068 patients

Phase 4Completed

NCT00261482 Johnson & Johnsonnorelgestromin + ethinyl estradiol

Evaluation of Women's Experience With EVRA (Norelgestromin + Ethinyl Estradiol) Transdermal Contraceptive Patch Compared With Previous Methods of Contraception.

Start: Jul 2003Est. completion: Dec 2004778 patients

Phase 4Completed

NCT00067509 Human BioSciencesemergency contraception

Emergency Contraception (ECP): Reducing Unintended Pregnancies

Start: Jun 2001Est. completion: May 20041,100 patients

Phase 4Completed

NCT00436306 Human BioSciencesIndividualized Intervention

Stage Matched Intervention to Increase Dual Method Use

Start: Oct 1999Est. completion: Dec 2005550 patients

Phase 4Completed

NCT00139685 PfizerDepo-Provera Contraceptive Injection - DP150CI

Depo-Provera: Bone Mineral Density and Total Body Calcium in Adolescent DP150CI Users and Non-Hormonal Contraception

Start: Apr 1998Est. completion: Jul 2007350 patients

Phase 4Completed

NCT04457076 Sebela PharmaceuticalsLevoCept

Evaluation of the Efficacy, Safety, and Tolerability of LevoCept

Start: Jun 2026Est. completion: Jun 20321,525 patients

Phase 3Not Yet Recruiting

NCT05264506 IQVIANOMAC-E2 COC

Contraceptive Efficacy and Safety of NOMAC-E2 Combined Oral Contraceptive

Start: Feb 2022Est. completion: Jan 20243,055 patients

Phase 3Terminated

NCT03243305 Evofem BiosciencesAMPHORA

AMP002 Phase III Contraceptive Study

Start: Jul 2017Est. completion: Nov 20181,384 patients

Phase 3Completed

NCT03074045 BayerLevonorgestrel

LCS16 vs. COC User Satisfaction and Tolerability Study

Start: Mar 2017Est. completion: Aug 2022145 patients

Phase 3Completed

NCT02985541 BayerLevonorgestrel IUS

Mirena Extension Trial

Start: Dec 2016Est. completion: May 2021364 patients

Phase 3Completed

NCT02403401 BayerLevonorgestrel

Safety and Contraceptive Efficacy of an Intravaginal Ring With LNG (Levonorgestrel) Over One Year in Healthy Women

Start: May 2015Est. completion: Jul 20161,471 patients

Phase 3Completed

NCT02064413 BayerESS310

Essure (Model ESS310) Placement Rate Study

Start: Mar 2014Est. completion: Nov 2014134 patients

Phase 3Completed

NCT01902264 BayerEE20/DRSP/L-5-MTHF

Study of Treatment With the Combination of Drospirenone Plus Ethinyl Estradiol Plus Levomefolate Calcium in Mexican Women Seeking Contraception

Start: Aug 2013Est. completion: Feb 201534 patients

Phase 3Completed

NCT01331655 BayerEE20/DRSP

Clinical Study of a Conventional and Flexible Extended Oral Contraceptive of EE/DRSP With or Without Metafolin in Latin America

Start: Apr 2013Est. completion: Nov 20140

Phase 3Withdrawn

NCT01638910 BayerEV/DNG

Efficacy and Safety of a Combined Oral Contraceptive of Estradiol Valerate and Dienogest in Healthy Female Subjects

Start: Jun 2012Est. completion: Nov 2014955 patients

Phase 3Completed

NCT01397097 BayerLNG-IUS

LCS12 vs. ENG Subdermal Implant (Nexplanon) Discontinuation Rate Study

Start: Sep 2011Est. completion: Apr 2015766 patients

Phase 3Completed

NCT01434160 BayerSkyla

LCS12 Adolescent Study

Start: Sep 2011Est. completion: May 2015304 patients

Phase 3Completed

NCT01306331 Evofem BiosciencesConceptrol

Study of Contraceptive Efficacy & Safety of Phexxi™ (Previously Known as Amphora) Gel Compared to Conceptrol Vaginal Gel

Start: Apr 2011Est. completion: Jun 20143,389 patients

Phase 3Completed

NCT01254292 BayerLevonorgestrel IUD

LCS12 vs Combined Oral Contraceptive (COC) User Satisfaction Study

Start: Jan 2011Est. completion: May 2014567 patients

Phase 3Completed

NCT01257984 BayerBAY86-5300

Study to Investigate Compliance With the Oral Contraceptive SH T00186D in a Flexible Extended Regimen Supported by a Dispenser With a Reminder Function

Start: Dec 2010Est. completion: Sep 2012508 patients

Phase 3Completed

NCT01236768 Agile TherapeuticsAG200-15

Transdermal Contraceptive Delivery System (TCDS), Also Known as AG200-15 Patch Arm

Start: Oct 2010Est. completion: Jun 2011407 patients

Phase 3Completed

NCT01181479 Agile TherapeuticsAG200-15

Study to Evaluate the Contraceptive Efficacy/Safety of a Low Dose EE/LNG Transdermal Contraceptive Delivery System

Start: Aug 2010Est. completion: Mar 20121,504 patients

Phase 3Completed

NCT01178125 TevaDR-102

A Study to Evaluate the Efficacy and Safety of DR-102 for the Prevention of Pregnancy

Start: Aug 2010Est. completion: Jan 20132,858 patients

Phase 3Completed

NCT00920985 BayerGestodene/EE

US Cycle Control and Blood Pressure Study

Start: Jun 2009Est. completion: Sep 2010346 patients

Phase 3Completed

NCT00984789 BayerEthinylestradiol/Gestodene

Birth Control Patch Study

Start: May 2009Est. completion: Sep 2010393 patients

Phase 3Completed

NCT00910637 BayerGestodene/EE Patch

Study Investigating the Efficacy and Safety of a Contraceptive Patch for 13 Cycles

Start: May 2009Est. completion: Dec 20101,502 patients

Phase 3Completed

NCT00914693 BayerEthinylestradiol/Gestodene

EU/LA Pearl Index Study - Transdermal Contraceptive Patch

Start: Apr 2009Est. completion: Sep 20111,694 patients

Phase 3Completed

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

37 late-stage (Phase 3) programs, potential near-term approvals

2 actively recruiting trials targeting 31,553 patients

30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.