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Contraception

126
Pipeline Programs
30
Companies
50
Clinical Trials
2 recruiting
10
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
18
4
21
1
37
45
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 218 programs with unclassified modality

On Market (10)

Approved therapies currently available

Bayer
MIRENAApproved
levonorgestrel
Bayer
Progestin [EPC]intrauterine2000
777K Part D
Bayer
KYLEENAApproved
levonorgestrel
Bayer
Progestin [EPC]intrauterine2016
49K Part D
Bayer
SKYLAApproved
levonorgestrel
Bayer
Progestin [EPC]intrauterine2013
13K Part D
Teva
LEVONORGESTRELApproved
levonorgestrel
Teva
oral2016
Teva
PLAN BApproved
levonorgestrel
Teva
oral1999
Teva
FALLBACK SOLOApproved
levonorgestrel
Teva
Progestin [EPC]oral2014
Teva
PLAN B ONE-STEPApproved
levonorgestrel
Teva
Progestin [EPC]oral2009
Pfizer
NORPLANT SYSTEM IN PLASTIC CONTAINERApproved
levonorgestrel
Pfizer
implantation1990
Agile Therapeutics
TWIRLAApproved
levonorgestrel/ethinyl estradiol
Agile Therapeutics
Estrogen [EPC]transdermal2020
Teva
HER STYLEApproved
levonorgestrel
Teva
Progestin [EPC]oral2016

Competitive Landscape

33 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
89 programs
6
13
30
5
EE20/DRSPPhase 41 trial
LevonorgestrelPhase 41 trial
LevonorgestrelPhase 41 trial
Long Acting Reversible ContraceptionPhase 41 trial
MirenaPhase 41 trial
+84 more programs
Active Trials
NCT02159261Completed1,500Est. Aug 2016
NCT03127722Completed990Est. Dec 2024
NCT00302848Completed59,510Est. Dec 2005
+86 more trials
Human BioSciences
3
3
3
1
2
5
Desogestrel / Ethinyl Estradiol PillPhase 41 trial
Individualized InterventionPhase 41 trial
MiglustatPhase 4Small Molecule1 trial
Ulipristal AcetatePhase 41 trial
emergency contraceptionPhase 41 trial
+21 more programs
Active Trials
NCT05240066Active Not Recruiting1,341Est. Jun 2026
NCT00065871Unknown250Est. Feb 2006
NCT05691270Terminated18Est. Jul 2024
+19 more trials
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
16 programs
2
7
Cannabidiol OilPhase 41 trial
ECx1Phase 41 trial
Immediate IUD insertionPhase 41 trial
Levonorgestrel IUSPhase 41 trial
Long Acting Reversible ContraceptionPhase 4
+11 more programs
Active Trials
NCT05988983Active Not Recruiting1,026Est. Mar 2026
NCT02169869Terminated33Est. Jun 2017
NCT03499379Completed39Est. Dec 2019
+11 more trials
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
11 programs
1
1
5
Desogestrel and Ethinyl Estradiol TabletsPhase 41 trial
Etonogestrel contraceptive implantPhase 4
Etonogestrel implantPhase 41 trial
Etonogestrel implantPhase 41 trial
Rifampin 600 MGPhase 4
+6 more programs
Active Trials
NCT03092037Completed900Est. Apr 2022
NCT01422226Terminated3Est. Aug 2012
NCT02067663Completed123Est. Sep 2015
+6 more trials
Sharp Therapeutics
1
4
Etonogestrel contraceptive implantPhase 4
Etonogestrel contraceptive implantPhase 4
Long Acting Reversible ContraceptionPhase 4
Rifampin 600 MGPhase 4
ENG implantPhase 1
+4 more programs
MSD
MSDIreland - Ballydine
9 programs
1
4
Etonogestrel contraceptive implantPhase 4
Etonogestrel contraceptive implantPhase 4
Long Acting Reversible ContraceptionPhase 4
Rifampin 600 MGPhase 4
ENG implantPhase 1
+4 more programs
Teva
TevaIsrael - Petach Tikva
6 programs
1
Immediate postpartum placement of IUDN/A1 trial
TV-46046PHASE_11 trial
TV-46046PHASE_11 trial
DR-1011PHASE_31 trial
DR-102PHASE_33 trials
+1 more programs
Active Trials
NCT02024672Completed96Est. Sep 2017
NCT03700658Completed27Est. Oct 2020
NCT04682353Completed60Est. Jan 2023
+5 more trials
Pfizer
PfizerNEW YORK, NY
6 programs
1
3
Depo-Provera Contraceptive Injection - DP150CIPhase 41 trial
Sayana PressPhase 41 trial
Subcutaneous depot medroxyprogesterone acetatePhase 41 trial
Levonorgestrel 90 mg/Ethinyl Estradiol 20 mgPhase 31 trial
Medroxyprogesterone 17-AcetateN/A1 trial
+1 more programs
Active Trials
NCT01019369Completed132Est. Nov 2012
NCT00775047Completed50Est. Jul 2008
NCT00245921Completed2,000Est. Oct 2005
+3 more trials
Agile Therapeutics
Agile TherapeuticsNJ - Princeton
4 programs
1
3
1
AG200-15Phase 31 trial
AG200-15Phase 31 trial
levonorgestrel and ethinyl estradiolPhase 3
TWIRLA(levonorgestrel)Phase 23 trials
Active Trials
NCT07739589Completed28Est. Nov 2021
NCT01623466Completed36Est. Sep 2012
NCT01250210Completed123Est. Feb 2008
+2 more trials
Innovation Pharmaceuticals
1 program
1
Copper IUDPhase 41 trial
Active Trials
NCT00733278Completed7Est. Sep 2008
CooperSurgical
CooperSurgicalCT - Trumbull
1 program
1
Paragard® T380A Intrauterine Copper Contraceptive with New InserterPhase 41 trial
Active Trials
NCT05309694Completed119Est. Dec 2022
Sebela Pharmaceuticals
3 programs
2
1
LevoCeptPhase 31 trial
LevoCeptPhase 21 trial
VeraCeptPhase 21 trial
Active Trials
NCT02882191Completed279Est. Nov 2020
NCT02446821Completed286Est. Mar 2019
NCT04457076Not Yet Recruiting1,525Est. Jun 2032
ViiV Healthcare
ViiV HealthcareNC - Durham
2 programs
1
1
Oral TestosteronePhase 21 trial
Testosterone EnanthatePhase 1/21 trial
Active Trials
NCT00399165Completed20Est. May 2007
NCT00161421Completed18Est. Jul 2006
Quotient Therapeutics
Quotient TherapeuticsMA - Cambridge
2 programs
2
E4/DRSPPhase 11 trial
EstetrolPhase 11 trial
Active Trials
NCT03512860Completed24Est. Oct 2018
NCT02720224Completed6Est. Apr 2016
Biolab Pharma
Biolab PharmaBrazil - São Paulo
1 program
1
Test formulationPhase 11 trial
Active Trials
NCT03443089Completed24Est. Aug 2017
KBio
KBioKY - Owensboro
1 program
1
ZB-06Phase 11 trial
Active Trials
NCT04731818Completed20Est. Feb 2022
Merck & Co.
Merck & Co.RAHWAY, NJ
9 programs
Etonogestrel ImplantN/A1 trial
Immediate Nexplanon InsertionN/A1 trial
Intervention GroupN/A1 trial
Track bleeding patterns before and after implantN/A1 trial
ENG implantPHASE_11 trial
+4 more programs
Active Trials
NCT03058978Completed117Est. Dec 2021
NCT02037919Completed148Est. May 2017
NCT03559634Completed55Est. Jan 2023
+5 more trials
Femasys
FemasysSUWANEE, GA
4 programs
FemBlocN/A1 trial
FemBlocN/A1 trial
FemBlocN/A1 trial
FemBloc® Permanent Contraceptive SystemN/A1 trial
Active Trials
NCT05977751Recruiting573Est. Jun 2031
NCT03433911Completed240Est. Feb 2025
NCT04273594Active Not Recruiting45Est. Apr 2027
+1 more trials
Daré Bioscience
OvapreneN/A1 trial
OvapreneN/A1 trial
Active Trials
NCT03598088Completed38Est. Nov 2019
NCT06127199Recruiting656Est. Sep 2027
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
2 programs
EVRA transdermal contraceptive patch 6 mg NGMN and 0.75 mg EEPHASE_11 trial
norelgestromin + ethinyl estradiolPHASE_34 trials
Active Trials
NCT00258076Completed53Est. Sep 2004
NCT00261482Completed778Est. Dec 2004
NCT00236769Completed1,751Est. Oct 1999
+2 more trials
Evofem Biosciences
Evofem BiosciencesCA - San Diego
2 programs
AMPHORAPHASE_31 trial
ConceptrolPHASE_31 trial
Active Trials
NCT03243305Completed1,384Est. Nov 2018
NCT01306331Completed3,389Est. Jun 2014
Parexel
ParexelMA - Boston
2 programs
AMPHORAPHASE_3
Ethinylestradiol/GestodenePHASE_3
Alliance Pharmaceuticals
1 program
Contraceptive app instant messagesN/A1 trial
Active Trials
NCT02905513Completed580Est. Nov 2017
Essential Pharmaceuticals
Control Latex Condom C, Polyurethane Condom A, Polyurethane Condom BN/A1 trial
Active Trials
NCT04622306Completed300Est. Dec 2021
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Family Planning Knowledge, Attitudes, and Practices of Postpartum Malawian WomenN/A1 trial
Active Trials
NCT01893021Completed634Est. Oct 2014
Purdue Pharma
Purdue PharmaCT - Stamford
1 program
HAPPI softwareN/A1 trial
Active Trials
NCT06823037Recruiting150Est. Aug 2026
Pathfinder Pharmaceuticals
Household VisitsN/A1 trial
Active Trials
NCT03226730Completed2,898Est. Mar 2021
Gedeon Richter
Gedeon RichterHungary - Budapest
1 program
International Active Surveillance Study: Native Estrogen Estetrol (E4) Safety StudyN/A1 trial
Active Trials
NCT06028555Recruiting101,000Est. Oct 2028
Forte Biosciences
1 program
Quality Improvement CollaborativeN/A1 trial
Active Trials
NCT05521646Unknown4,000Est. Sep 2025
Labcorp
LabcorpBURLINGTON, NC
1 program
Radio Mass Media Family Planning CampaignN/A

+3 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Human BioSciencesDesogestrel / Ethinyl Estradiol Pill
Colorado TherapeuticsEtonogestrel implant
CooperSurgicalParagard® T380A Intrauterine Copper Contraceptive with New Inserter
Agile Therapeuticslevonorgestrel
Colorado TherapeuticsDesogestrel and Ethinyl Estradiol Tablets
Colorado TherapeuticsEtonogestrel implant
Merck & Co.Rifampin 600 MG
Merck & Co.Etonogestrel contraceptive implant
Oregon TherapeuticsCannabidiol Oil
Human BioSciencesUlipristal Acetate
PfizerSayana Press
Merck & Co.Etonogestrel contraceptive implant
BayerLevonorgestrel
BayerEE20/DRSP
BayerLong Acting Reversible Contraception

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 29,887 patients across 50 trials

NCT06334315Human BioSciencesDesogestrel / Ethinyl Estradiol Pill

Oral Contraceptive Pill (OCP) Pharmacogenomics

Start: Oct 2024Est. completion: May 2028700 patients
Phase 4Recruiting

Etonogestrel Implant as Emergency Contraception

Start: Apr 2022Est. completion: Dec 202612 patients
Phase 4Recruiting
NCT05309694CooperSurgicalParagard® T380A Intrauterine Copper Contraceptive with New Inserter

A Study to Assess the Safety of a New Inserter Device for Paragard® (Intrauterine Copper Contraceptive)

Start: Mar 2022Est. completion: Dec 2022119 patients
Phase 4Completed

A Postmarketing Open-Label Study to Assess Residual Levonorgestrel (LNG) and Ethinyl Estradiol (EE) Content of TWIRLA® (Levonorgestrel and Ethinyl Estradiol) Transdermal System

Start: Oct 2021Est. completion: Nov 202128 patients
Phase 4Completed
NCT05002738Colorado TherapeuticsDesogestrel and Ethinyl Estradiol Tablets

Desogestrel-containing COCP Pharmacokinetic Validation Study

Start: Sep 2021Est. completion: Nov 202222 patients
Phase 4Completed

Shoulder Contraceptive Implant Study

Start: Oct 2020Est. completion: Feb 20225 patients
Phase 4Completed
NCT04463680Merck & Co.Rifampin 600 MG

Rifampin and the Contraceptive Implant

Start: Sep 2020Est. completion: Feb 202224 patients
Phase 4Completed
NCT04423055Merck & Co.Etonogestrel contraceptive implant

Nexplanon Use in Women Primarily Choosing a Combined Oral Contraceptive

Start: Aug 2020Est. completion: Apr 2024120 patients
Phase 4Completed

Cannabidiol and Oral Contraceptive Pills: Exploring a Drug-Drug Interaction

Start: Apr 2020Est. completion: Mar 20229 patients
Phase 4Completed

Study Comparing Emergency Contraception Effectiveness in Women Who Weight ≥ 80 kg

Start: Jul 2018Est. completion: Apr 2022532 patients
Phase 4Terminated
NCT03034057PfizerSayana Press

Sayana Press UK Self-Injection Study

Start: Aug 2017Est. completion: Dec 2018169 patients
Phase 4Completed
NCT02852265Merck & Co.Etonogestrel contraceptive implant

Nexplanon and Combined Oral Contraceptive (COC) Combined Use Study

Start: Sep 2016Est. completion: Jul 201720 patients
Phase 4Completed
NCT02957292BayerLevonorgestrel

A Study to Compare the Menstrual Bleeding Profile Among Jaydess® and Copper Intrauterine Device (IUD) Users. COLIBRI STUDY (Copper and Levonorgestrel IUD Barcelona Research Initiative).

Start: Jun 2016Est. completion: Sep 2020108 patients
Phase 4Completed

YAZ Post Authorization Safety Study (PASS)/Post Authorization Efficacy Study (PAES) in China

Start: May 2016Est. completion: Jul 20181,921 patients
Phase 4Completed
NCT02735551BayerLong Acting Reversible Contraception

LARC Forward Contraceptive Counseling at MHCC

Start: Apr 2016Est. completion: Mar 20173 patients
Phase 4Terminated

Impact of Combined Hormonal Contraceptives on UPA

Start: Sep 2015Est. completion: Jun 201736 patients
Phase 4Completed
NCT02509767PfizerSubcutaneous depot medroxyprogesterone acetate

Depo Provera Self-Administration Study: Putting a Patient-Centered Practice to the Test at Planned Parenthood

Start: Aug 2015Est. completion: Dec 2017401 patients
Phase 4Completed

Emergency Contraception and Body Weight: Pilot Study

Start: Feb 2015Est. completion: Aug 201510 patients
Phase 4Completed

Early Postpartum Intrauterine Device (IUD) Placement

Start: Mar 2012Est. completion: Jul 2014201 patients
Phase 4Terminated

Intrauterine Contraceptive Device (IUD) Placement at Time of C-Section

Start: Nov 2007Est. completion: Sep 20087 patients
Phase 4Completed
NCT00562276Oregon TherapeuticsImmediate IUD insertion

Immediate Versus Delayed Intrauterine Device (IUD) Insertion Following First Trimester Suction Aspiration Procedures

Start: May 2007Est. completion: Jun 2009578 patients
Phase 4Completed
NCT00393198BayerLevonorgestrel

Bleeding Pattern and User Satisfaction During Second Consecutive MIRENA® in Contraception and Treatment of Menorrhagia

Start: Oct 2006Est. completion: Oct 2012204 patients
Phase 4Completed
NCT00662454Oregon Therapeuticsethinyl estradiol / levonorgestrel

Oral Contraceptive Efficacy and Body Weight

Start: Jan 2006Est. completion: May 2006120 patients
Phase 4Completed

HR-QoL and Sexuality in Mirena Inserted Contraception Users

Start: Nov 2005Est. completion: Oct 2007141 patients
Phase 4Completed

Glycosphingolipid Inhibition and Spermatogenesis in Man: A Pilot Study (MIG 2)

Start: Jun 2005Est. completion: Jan 20068 patients
Phase 4Completed
NCT00261482Johnson & Johnsonnorelgestromin + ethinyl estradiol

Evaluation of Women's Experience With EVRA (Norelgestromin + Ethinyl Estradiol) Transdermal Contraceptive Patch Compared With Previous Methods of Contraception.

Start: Jul 2003Est. completion: Dec 2004778 patients
Phase 4Completed
NCT00067509Human BioSciencesemergency contraception

Emergency Contraception (ECP): Reducing Unintended Pregnancies

Start: Jun 2001Est. completion: May 20041,100 patients
Phase 4Completed
NCT00436306Human BioSciencesIndividualized Intervention

Stage Matched Intervention to Increase Dual Method Use

Start: Oct 1999Est. completion: Dec 2005550 patients
Phase 4Completed
NCT00139685PfizerDepo-Provera Contraceptive Injection - DP150CI

Depo-Provera: Bone Mineral Density and Total Body Calcium in Adolescent DP150CI Users and Non-Hormonal Contraception

Start: Apr 1998Est. completion: Jul 2007350 patients
Phase 4Completed

Evaluation of the Efficacy, Safety, and Tolerability of LevoCept

Start: Jun 2026Est. completion: Jun 20321,525 patients
Phase 3Not Yet Recruiting
NCT05264506IQVIANOMAC-E2 COC

Contraceptive Efficacy and Safety of NOMAC-E2 Combined Oral Contraceptive

Start: Feb 2022Est. completion: Jan 20243,055 patients
Phase 3Terminated

AMP002 Phase III Contraceptive Study

Start: Jul 2017Est. completion: Nov 20181,384 patients
Phase 3Completed
NCT03074045BayerLevonorgestrel

LCS16 vs. COC User Satisfaction and Tolerability Study

Start: Mar 2017Est. completion: Aug 2022145 patients
Phase 3Completed
NCT02985541BayerLevonorgestrel IUS

Mirena Extension Trial

Start: Dec 2016Est. completion: May 2021364 patients
Phase 3Completed
NCT02403401BayerLevonorgestrel

Safety and Contraceptive Efficacy of an Intravaginal Ring With LNG (Levonorgestrel) Over One Year in Healthy Women

Start: May 2015Est. completion: Jul 20161,471 patients
Phase 3Completed

Essure (Model ESS310) Placement Rate Study

Start: Mar 2014Est. completion: Nov 2014134 patients
Phase 3Completed
NCT01902264BayerEE20/DRSP/L-5-MTHF

Study of Treatment With the Combination of Drospirenone Plus Ethinyl Estradiol Plus Levomefolate Calcium in Mexican Women Seeking Contraception

Start: Aug 2013Est. completion: Feb 201534 patients
Phase 3Completed

Clinical Study of a Conventional and Flexible Extended Oral Contraceptive of EE/DRSP With or Without Metafolin in Latin America

Start: Apr 2013Est. completion: Nov 20140
Phase 3Withdrawn

Efficacy and Safety of a Combined Oral Contraceptive of Estradiol Valerate and Dienogest in Healthy Female Subjects

Start: Jun 2012Est. completion: Nov 2014955 patients
Phase 3Completed

LCS12 vs. ENG Subdermal Implant (Nexplanon) Discontinuation Rate Study

Start: Sep 2011Est. completion: Apr 2015766 patients
Phase 3Completed

LCS12 Adolescent Study

Start: Sep 2011Est. completion: May 2015304 patients
Phase 3Completed

Study of Contraceptive Efficacy & Safety of Phexxi™ (Previously Known as Amphora) Gel Compared to Conceptrol Vaginal Gel

Start: Apr 2011Est. completion: Jun 20143,389 patients
Phase 3Completed
NCT01254292BayerLevonorgestrel IUD

LCS12 vs Combined Oral Contraceptive (COC) User Satisfaction Study

Start: Jan 2011Est. completion: May 2014567 patients
Phase 3Completed

Study to Investigate Compliance With the Oral Contraceptive SH T00186D in a Flexible Extended Regimen Supported by a Dispenser With a Reminder Function

Start: Dec 2010Est. completion: Sep 2012508 patients
Phase 3Completed

Transdermal Contraceptive Delivery System (TCDS), Also Known as AG200-15 Patch Arm

Start: Oct 2010Est. completion: Jun 2011407 patients
Phase 3Completed

Study to Evaluate the Contraceptive Efficacy/Safety of a Low Dose EE/LNG Transdermal Contraceptive Delivery System

Start: Aug 2010Est. completion: Mar 20121,504 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of DR-102 for the Prevention of Pregnancy

Start: Aug 2010Est. completion: Jan 20132,858 patients
Phase 3Completed
NCT00920985BayerGestodene/EE

US Cycle Control and Blood Pressure Study

Start: Jun 2009Est. completion: Sep 2010346 patients
Phase 3Completed
NCT00984789BayerEthinylestradiol/Gestodene

Birth Control Patch Study

Start: May 2009Est. completion: Sep 2010393 patients
Phase 3Completed
NCT00910637BayerGestodene/EE Patch

Study Investigating the Efficacy and Safety of a Contraceptive Patch for 13 Cycles

Start: May 2009Est. completion: Dec 20101,502 patients
Phase 3Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

37 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 29,887 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.