Avalo Therapeutics(AVTX)

Focus: Avalo Therapeutics is a public-stage biotech focused on small molecules for neuropsychiatric disorders, with a diversified pipeline spanning ADHD, depression, and inflammatory conditions. The company is pre-revenue to micro-revenue, operating as a clinical-stage innovator.

Psychiatry

Profile data last refreshed 2h ago · AI intelligence enriched 3w ago

Funding Stage

PUBLIC

Open Jobs

13-1 this month

Stable — net -1 jobs in 30d

4 added, 5 removed. Backfill posture.

Should You Work at Avalo Therapeutics?

AI assessment

Avalo is a high-risk, early-stage clinical biotech suitable for scientists seeking formative drug-development experience and upside optionality, but unsuitable for those prioritizing revenue stability, organizational scale, or near-term clinical catalysts.

Why Work Here

Lead role in a focused therapeutic area (psychiatry/neurology) with clinical-stage depth: NFC-1 in Phase 2/3 for ADHD, CERC-301 in Phase 2 for MDD

Data completeness

5/9 — Partial

Company HealthStrong

Pipeline

Early-stage

13 total

LOE Risk

Protected

No near-term cliffs

Hiring

Stable

Revenue

$441K

Pipeline & Clinical Trials

A Non-interventional Study to Identify Children and Adolescents With ADHD and With or Without mGLuR

Attention Deficit Hyperactivity Disorder

N/A

Clinical Trials (1)

NCT03233867A Non-interventional Study to Identify Children and Adolescents With ADHD and With or Without mGLuR Mutations

N/A

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Data Sources

Drug label: DailyMed / FDA
Clinical trials: ClinicalTrials.gov
Patent data: FDA Orange Book
Spending data: CMS Medicare

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.

Recently capitalized with $135M cash (FY 2025) following public listing, providing runway for clinical advancement and rare hiring momentum

Exposure to small-molecule drug discovery and development across 13 active programs with 20 ongoing trials, building portfolio depth

Watch Out For

Extreme pre-commercial stage: only $441K revenue (FY 2025) with -$35.1M net loss; significant burn rate means 3–5 year horizon to Phase 3 readouts with no guarantee of approval
Micro-scale operation (14 active job openings suggest <100 headcount); limited career infrastructure, mentorship depth, or internal mobility compared to established biotech
Pipeline appears scattered across 13 programs in disparate indications (ADHD, depression, lymphatic malformation, renal anemia, cough, Crohn's, COVID, hidradenitis, oncology); lack of clear focus risks capital dilution and lower odds of clinical success per program

Generated by Claude from Avalo Therapeutics's SEC filings, pipeline programs, hiring velocity, FDA actions, and WARN data. Inference, not editorial — verify before quoting.

Automated analysis based on publicly available data (FDA, SEC, ClinicalTrials.gov). May be incomplete or delayed. This score does not reflect insider knowledge and should not be used as the sole basis for investment or employment decisions.

A Noninterventional Genotype/Phenotype Study of mGluR Mutations in Children and Adolescents With ADH

Attention Deficit Disorder With Hyperactivity

N/A

Clinical Trials (1)

NCT02811211A Noninterventional Genotype/Phenotype Study of mGluR Mutations in Children and Adolescents With ADHD

N/A

MDGN-002

Crohn's Disease

Phase 1

Clinical Trials (1)

NCT03169894Evaluation of the Safety, Tolerability, and Efficacy of MDGN-002 in Adults With Moderate to Severe Active Crohn's Disease or Ulcerative Colitis

Phase 1

AEVI-007

Multiple Myeloma

Phase 1

Clinical Trials (1)

NCT04671251Phase 1b Study of AEVI-007 in Subjects With Relapsed or Refractory Multiple Myeloma

Phase 1

CERC-006

Lymphatic Malformation

Phase 1

Clinical Trials (1)

NCT04994002A Pharmacokinetic, Pharmacodynamic, Safety and Tolerability Study of CERC-006 in Adults With Complex Lymphatic Malformations

Phase 1

AVTX-002

Non-Eosinophilic Asthma

Phase 2

Clinical Trials (1)

NCT05288504A Study to Evaluate the Safety and Efficacy of AVTX-002 for the Treatment of Poorly Controlled Non-Eosinophilic Asthma.

Phase 2

CERC-002

COVID-19 Pneumonia

Phase 2

Clinical Trials (1)

NCT04412057Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury

Phase 2

FP01

Acute Cough

Phase 2

Clinical Trials (3)

NCT01597349Antitussive Effects of FP01 Lozenges in Subjects With Cough Due to Upper Respiratory Tract Infection

Phase 2

NCT01703923An Exploratory Study of FP01 Lozenges in Subjects With Chronic Refractory Cough

Phase 2

NCT01579526A Single Dose Study to Determine the Safety and Pharmacokinetics of FP01 Lozenges in Healthy Volunteers

Phase 1

AVTX-009

Hidradenitis Suppurativa

Phase 2

Clinical Trials (1)

NCT06603077A Study to Evaluate the Efficacy and Safety of AVTX-009 in Patients With Moderate to Severe Hidradenitis Suppurativa

Phase 2

CERC-301

Major Depressive Disorder

Phase 2

Clinical Trials (2)

NCT01941043A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Study of CERC-301 in the Adjunctive Treatment of Subjects With Severe Depression and Recent Active Suicidal Ideation Despite Antidepressant Treatment

Phase 2

NCT02459236A Study of Intermittent Doses of CERC-301 in MDD

Phase 2

MDGN201 TARGTEPO

Anemia of End Stage Renal Disease

Phase 2

Clinical Trials (1)

NCT02468414TARGTEPO Treatment for Anemia in PD US Trial

Phase 2

AEVI-001

Attention Deficit Hyperactivity Disorder

Phase 2

Clinical Trials (2)

NCT03609619PART B: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and Without mGluR Mutations

Phase 2

NCT03265119PART A: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and With mGluR Mutations

Phase 2

NFC-1

Attention Deficit Hyperactivity Disorder

Phase 2/3

Clinical Trials (4)

NCT02777931Efficacy and Safety of NFC-1 in Adolescents With Genetic Disorders Impacting mGluR and ADHD

Phase 2/3

NCT03006367Pharmacokinetic and Tolerability Study of NFC-1 in Subjects Aged 6-17 Years With ADHD

Phase 1

NCT02286817Phase I Single Dose, Open-Label Pharmacokinetic Study and Single-Blind, Placebo-Controlled Dose Escalation Study of NFC-1 in Adolescents With Attention-Deficit Hyperactivity Disorder

Phase 1

+1 more

Interview Prep Quick Facts

Portfolio: 20 clinical trials

Top TAs: Respiratory, Dermatology, Hematology

Publications: 2 in PubMed

SEC Filings: 2 available

Open Roles: 13 active jobs

Therapeutic Area Focus

3 pipeline

1 pipeline

1 pipeline

1 pipeline

1 pipeline

Financials (FY2025)

Revenue

$441K77%

R&D Spend

$24M(5541%)77%

Net Income

-$35M

Hiring Trend

Stable

Open Roles

Added

-0

Filled/Removed

Based on last 4 crawl cycles

Research Publications(2)

Recent peer-reviewed publications with author affiliations at this company

Realigning the LIGHT signaling network to control dysregulated inflammation.

The Journal of experimental medicine

2022

PMID:35604387

Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome.

The Journal of clinical investigation

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Avalo Therapeutics(AVTX)

Should You Work at Avalo Therapeutics?

Why Work Here

Pipeline & Clinical Trials

Watch Out For

Recent News · Avalo Therapeutics(10)

Open Jobs (13)

Senior Manager, R&D Accounting

Senior Director, Controller

Clinical Trial Manager

Clinical Trial Associate

Associate Director/Director, Information Technology

Director Data Management

Health Economics & Outcomes Research and Market Access Lead (Contract)

Director of Regulatory Affairs

Sr. Manager/ Associate Director, Biostatistics

Head of Global Marketing & Launch Lead, Dermatology

Sr. Manager/ Associate Director, Statistical Programming

General Application

Medical Director/Sr. Medical Director, Clinical Development

Financials (FY2025)

Hiring Trend

Research Publications(2)