Skip to main content

Attention Deficit Hyperactivity Disorder

94
Pipeline Programs
30
Companies
50
Clinical Trials
5
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
16
4
31
40
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
150%
Cell Therapy
150%
+ 114 programs with unclassified modality

On Market (5)

Approved therapies currently available

Eli Lilly and Company
STRATTERAApproved
atomoxetine hydrochloride
Eli Lilly and Company
oral2002
2M Part D
Novartis
RITALIN LAApproved
methylphenidate
Novartis
oral2002
1M Part D
Novartis
RITALINApproved
methylphenidate hydrochloride
Novartis
oral1955
756K Part D
Noven Pharmaceuticals
DAYTRANAApproved
methylphenidate
Noven Pharmaceuticals
Central Nervous System Stimulant [EPC]transdermal2006
429K Part D
Purdue Pharma
ADHANSIA XRApproved
methylphenidate hydrochloride
Purdue Pharma
oral2019

Competitive Landscape

37 companies ranked by most advanced pipeline stage

Prevail Therapeutics
46 programs
1
3
3
19
18
AtomoxetinePhase 4
AtomoxetinePhase 4
AtomoxetinePhase 4
AtomoxetinePhase 4
AtomoxetinePhase 4
+41 more programs
Sandoz
SandozAustria - Kundl
6 programs
1
1
2
2
Dex-methylphenidate hydrochloride extended-releasePhase 41 trial
MethylphenidatePhase 41 trial
DexmethylphenidatePhase 31 trial
Methylphenidate 20 mg long-acting capsulesPhase 31 trial
Extended Release MethylphenidatePhase 21 trial
+1 more programs
Active Trials
NCT00772161Completed24Est. Dec 2008
NCT00409708Completed142
NCT00393042Completed77Est. Feb 2009
+3 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
4 programs
1
Dietary Intake and Nutrient Status of Children With ADHDN/A1 trial
EdivoxetinePHASE_2_31 trial
AtomoxetinePHASE_41 trial
Atomoxetine HydrochloridePHASE_41 trial
Active Trials
NCT00434928Completed60Est. Jan 2007
NCT00965419Terminated267Est. Jul 2015
NCT00406354Completed181Est. Jan 2009
+1 more trials
Pfizer
PfizerNEW YORK, NY
4 programs
1
2
1
Methylphenidate HydrochloridePhase 41 trial
NWP09Phase 31 trial
Quillivant Oral Suspension XRPhase 31 trial
AtomoxetinePhase 21 trial
Active Trials
NCT00562055Withdrawn0
NCT01654250Completed90Est. Oct 2012
NCT00904670Completed45Est. Aug 2009
+1 more trials
Novartis
NovartisBASEL, Switzerland
3 programs
1
MethylphenidatePHASE_1_2
Extended Release MethylphenidatePHASE_2
Methylphenidate 20 mg long-acting capsulesPHASE_3
Noven Pharmaceuticals
3 programs
1
1
1
DaytranaPhase 41 trial
Methylphenidate Transdermal SystemPhase 31 trial
d-Amphetamine Transdermal PatchPhase 21 trial
Active Trials
NCT01711021Completed110Est. Mar 2013
NCT00444574Completed282Est. Jun 2005
NCT00434213Completed309Est. Jul 2008
Purdue Pharma
Purdue PharmaCT - Stamford
3 programs
1
2
FoquestPhase 41 trial
Methylphenidate Hydrochloride Controlled-Release CapsulesPhase 41 trial
PRC-063Phase 31 trial
Active Trials
NCT02555150Completed40Est. Jan 2017
NCT04741516Unknown41Est. Dec 2023
NCT03785223Completed60Est. Oct 2022
JPM
3 programs
3
FoquestPhase 4
Guanfacine extended releasePhase 41 trial
Lisdexamfetamine DimesylatePhase 41 trial
Active Trials
NCT01985581Completed50Est. Mar 2015
NCT03337646Completed48Est. Mar 2023
Human BioSciences
1
MethylphenidatePhase 41 trial
Behavioral Social Skills TrainingN/A1 trial
Active Trials
NCT05102344Completed39Est. Aug 2023
NCT01133847Completed222Est. Jun 2015
Aytu BioPharma
Aytu BioPharmaDENVER, CO
2 programs
2
ADZENYS XR-ODTPhase 41 trial
amphetamine extended-release orally disintegrating tabletPhase 4
Active Trials
NCT07169162Withdrawn0Est. Sep 2025
Acadia Pharmaceuticals
2 programs
2
L. helveticus R0052 and B. longum R0175Phase 41 trial
probioticsPhase 41 trial
Active Trials
NCT02545634Unknown100Est. Jun 2016
NCT02035878Unknown75Est. Apr 2014
Monarch Therapeutics
1
AtomoxetinePhase 4
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
BupropionPhase 41 trial
Active Trials
NCT00936299Completed105Est. May 2013
Martin Pharmaceuticals
1 program
1
CariprazinePhase 41 trial
Active Trials
NCT04843423Unknown15Est. Apr 2023
Medice
MediceGermany - Iserlohn
3 programs
2
methylphenidate hydrochloridePhase 31 trial
methylphenidate hydrochloridePhase 31 trial
Attentin® in Children and Adolescents With ADHD - A Non-interventional StudyN/A1 trial
Active Trials
NCT02801604Completed150Est. Dec 2019
NCT00730249Completed150
NCT00619840Completed363
Alvogen
AlvogenNJ - Morristown
1 program
1
AK-D101Phase 31 trial
Active Trials
NCT07678827Not Yet Recruiting156Est. Sep 2027
Shionogi
ShionogiJapan - Osaka
1 program
1
CLONICELPhase 3Cell Therapy1 trial
Active Trials
NCT00723190Completed303Est. Jun 2010
Medica Corp
Medica CorpMA - Bedford
1 program
1
ProspektaPhase 31 trial
Active Trials
NCT04569357Completed363Est. Feb 2022
Supernus Pharmaceuticals
1 program
1
SPN-810Phase 31 trial
Active Trials
NCT03597503Terminated41Est. Jan 2020
Avalo Therapeutics
3 programs
1
1
NFC-1Phase 2/34 trials
AEVI-001Phase 22 trials
A Non-interventional Study to Identify Children and Adolescents With ADHD and With or Without mGLuR N/A1 trial
Active Trials
NCT03233867Completed2,503Est. Aug 2018
NCT03609619Completed109Est. Nov 2018
NCT03265119Completed69Est. Oct 2018
+4 more trials
Otsuka
OtsukaJapan - Tokushima
4 programs
1
3
CentanafadinePhase 21 trial
OPDC-34712Phase 21 trial
aripiprazolePhase 2Small Molecule1 trial
CentanafadinePhase 11 trial
Active Trials
NCT04398225Completed32Est. Apr 2021
NCT04081363Completed13Est. Dec 2019
NCT01074294Completed740Est. Jun 2011
+1 more trials
Abbott
AbbottABBOTT PARK, IL
1 program
1
ABT-089Phase 21 trial
Active Trials
NCT00443391Completed141Est. Oct 2008
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
ABT-089Phase 2
RespireRx Pharmaceuticals
1
CX717 200 mgPhase 21 trial
Active Trials
NCT03375021Completed68Est. Jan 2006
MSD
MSDIreland - Ballydine
1 program
1
MK-8777Phase 21 trial
Active Trials
NCT00610441Completed67Est. Mar 2009
Sharp Therapeutics
1
MK-8777Phase 2
Lundbeck
LundbeckDenmark - Copenhagen
1 program
1
vortioxetine 10 mg tabletPhase 21 trial
Active Trials
NCT02327013Completed227Est. Sep 2016
Oregon Therapeutics
EmpowerPlus Lightning SticksN/A1 trial
Mental health care implemented by telepsychiatryN/A1 trial
NAT electroencephalographyN/A1 trial
Active Trials
NCT05234593Completed20Est. Apr 2023
NCT01096953Withdrawn0Est. Sep 2011
NCT02756286Completed258Est. Jul 2018
Angeles Therapeutics
NAT electroencephalographyN/A
UC-AN/A1 trial
Active Trials
NCT06256003Completed140Est. Nov 2024
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
2 programs
Performance and FMRI BOLD Signal Changes in Impulsive PatientsN/A1 trial
Zentiva®N/A1 trial
Active Trials
NCT06491160Completed20Est. Oct 2024
NCT05278104Completed63Est. Oct 2024

+7 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Martin PharmaceuticalsCariprazine
Purdue PharmaFoquest
TakedaGuanfacine hydrochloride
Aytu BioPharmaADZENYS XR-ODT
Purdue PharmaMethylphenidate Hydrochloride Controlled-Release Capsules
JPMLisdexamfetamine Dimesylate
PfizerMethylphenidate Hydrochloride
Acadia PharmaceuticalsL. helveticus R0052 and B. longum R0175
JPMGuanfacine extended release
Human BioSciencesMethylphenidate
Colorado TherapeuticsBupropion
Heidelberg PharmaAtomoxetine
SandozDex-methylphenidate hydrochloride extended-release
SandozMethylphenidate
Noven PharmaceuticalsDaytrana

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 7,179 patients across 50 trials

Adjunct Treatment With Cariprazine for Adults With Attention-deficit/Hyperactivity Disorder

Start: Dec 2021Est. completion: Apr 202315 patients
Phase 4Unknown

Evaluation of the Effect Foquest® on Sleep in Children Aged 6-12 With ADHD

Start: Dec 2020Est. completion: Dec 202341 patients
Phase 4Unknown
NCT04085172TakedaGuanfacine hydrochloride

A Study of TAK-503 in Children and Teenagers With Attention Deficit Hyperactivity Disorder (ADHD)

Start: Sep 2019Est. completion: Sep 2025396 patients
Phase 4Completed

ADZENYS XR-ODT™ in Children (4 to <6 Years) Diagnosed With Attention-deficit/Hyperactivity Disorder

Start: May 2019Est. completion: Sep 20250
Phase 4Withdrawn
NCT03785223Purdue PharmaMethylphenidate Hydrochloride Controlled-Release Capsules

A 14 Week, Randomized, Placebo-Controlled Cross-Over Study of Methylphenidate Hydrochloride Controlled Release Capsules in Adult ADHD With and Without Anxiety Disorder Comorbidity

Start: Apr 2019Est. completion: Oct 202260 patients
Phase 4Completed
NCT03337646JPMLisdexamfetamine Dimesylate

Evaluation of the Effect and Safety of Lisdexamfetamine in Children Aged 6-12 With ADHD and Autism

Start: Sep 2018Est. completion: Mar 202348 patients
Phase 4Completed
NCT03536390PfizerMethylphenidate Hydrochloride

A 6-week Study to Evaluate the Safety and Efficacy of Methylphenidate HCl ERCT in 4-5 Year Old Children With ADHD

Start: Sep 2018Est. completion: Apr 20210
Phase 4Withdrawn
NCT02545634Acadia PharmaceuticalsL. helveticus R0052 and B. longum R0175

Effects of a Probiotic Supplement on Symptoms of Attention Deficit Hyperactivity Disorder and Anxiety in Children

Start: Jun 2015Est. completion: Jun 2016100 patients
Phase 4Unknown
NCT01985581JPMGuanfacine extended release

Efficacy of GXR as Adjunctive Therapy With Psycho-stimulant on Executive Function in Children With ADHD

Start: Oct 2013Est. completion: Mar 201550 patients
Phase 4Completed

Interventions for Children With Attention and Reading Disorders

Start: Nov 2010Est. completion: Jun 2015222 patients
Phase 4Completed

Bupropion for ADHD in Adolescents With Substance Use Disorder

Start: Jan 2009Est. completion: May 2013105 patients
Phase 4Completed

Driving in Adults With Attention-deficit/Hyperactivity Disorder (ADHD) Before and During Treatment With Atomoxetine

Start: Jan 2008Est. completion: Dec 200950 patients
Phase 4Completed
NCT00564954SandozDex-methylphenidate hydrochloride extended-release

A Study of Dex-methylphenidate Extended Release in Children (6-12 Years) With Attention-Deficit/Hyperactivity Disorder (ADHD)

Start: Oct 2007Est. completion: Nov 200786 patients
Phase 4Completed
NCT00536419SandozMethylphenidate

Impact of Attention Deficit/Hyperactivity Disorder and Substance Use Disorder on Motorcycle Traffic Accidents

Start: Sep 2007Est. completion: Sep 200853 patients
Phase 4Unknown

Characterization of Dermal Reactions in Pediatric Patients With ADHD Using DAYTRANA

Start: Jan 2007Est. completion: Jul 2008309 patients
Phase 4Completed

Comparison of Atomoxetine Versus Placebo in Children and Adolescents With ADHD and Comorbid ODD in Germany

Start: Nov 2006Est. completion: Jan 2009181 patients
Phase 4Completed
NCT00190775Eli Lilly and CompanyAtomoxetine Hydrochloride

A Randomized, Double-Blind Comparison of Placebo and Atomoxetine Hydrochloride Given Once a Day in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)

Start: Sep 2004Est. completion: Oct 2009502 patients
Phase 4Completed
NCT00381758UCB PharmaMethylphenidate Extended Release Capsules

The COMACS Study: A Comparison of Methylphenidates in an Analog Classroom Setting

Start: May 2002Est. completion: Aug 2002184 patients
Phase 4Completed

A Phase 3 Study of Viloxazine ER Capsules in Korean Children and Adolescents With ADHD

Start: Jul 2026Est. completion: Sep 2027156 patients
Phase 3Not Yet Recruiting

Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Attention Deficit/Hyperactivity Disorder in Children

Start: Nov 2020Est. completion: Feb 2022363 patients
Phase 3Completed

Treatment of Impulsive Aggression (IA) in Adolescent With ADHD in Conjunction With Standard ADHD Treatment

Start: Jul 2018Est. completion: Jan 202041 patients
Phase 3Terminated

A Comparison of PRC-063 and Lisdexamfetamine in the Driving Performance of Adults With ADHD

Start: Sep 2015Est. completion: Jan 201740 patients
Phase 3Completed

NWP09 in Children With Attention Deficit Hyperactivity Disorder (ADHD)

Start: Jul 2012Est. completion: Oct 201290 patients
Phase 3Completed
NCT00904670PfizerQuillivant Oral Suspension XR

Quillivant Oral Suspension (Quillivant XR) in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD)

Start: Apr 2009Est. completion: Aug 200945 patients
Phase 3Completed
NCT00730249Medicemethylphenidate hydrochloride

Quality Assurance of Administering Methylphenidate in Adults With Attention Deficit Hyperactivity Disorder (ADHD) - QUMEA

Start: Sep 2008150 patients
Phase 3Completed

Open-Label, Chronic Exposure, Safety Study of CLONICEL (Clonidine HCl Sustained Release) in Children and Adolescents With Attention Deficit Hyperactivity Disorder (ADHD)

Start: Jan 2008Est. completion: Jun 2010303 patients
Phase 3Completed
NCT00428792SandozMethylphenidate 20 mg long-acting capsules

Safety and Efficacy of Methylphenidate in Children With Attention-deficit Hyperactivity Disorder (ADHD)

Start: Apr 2007Est. completion: Dec 2007150 patients
Phase 3Completed

Study to Evaluate the Efficacy of Modafinil Treatment in Patients With Attention Deficit Hyperactivity Disorder (ADHD) Who Are Responders to Modafinil Treatment

Start: Jun 2006Est. completion: Sep 2006120 patients
Phase 3Completed
NCT00393042SandozDexmethylphenidate

Sleep and Tolerability Study: Comparing the Effects of Adderall XR and Focalin XR

Start: Jan 2006Est. completion: Feb 200977 patients
Phase 3Completed
NCT00619840Medicemethylphenidate hydrochloride

Placebo-Controlled Multi-Centre Double-Blind Trial for Adults With Extended-Release Methylphenidate for ADHD

Start: Nov 2004363 patients
Phase 3Completed
NCT00444574Noven PharmaceuticalsMethylphenidate Transdermal System

Safety and Efficacy of MTS Versus Concerta in Pediatric Patients (Aged 6-12 Years) With ADHD

Start: Sep 2004Est. completion: Jun 2005282 patients
Phase 3Completed

Efficacy and Safety of NFC-1 in Adolescents With Genetic Disorders Impacting mGluR and ADHD

Start: Jun 2016Est. completion: Feb 2017101 patients
Phase 2/3Completed

A Study of Pediatric Participants With Attention Deficit/Hyperactivity Disorder

Start: Sep 2009Est. completion: Jul 2015267 patients
Phase 2/3Terminated
NCT04081363OtsukaCentanafadine

Open-label, Single-dose Trial to Assess the Pharmacokinetics of Centanafadine Extended-release Capsules in Pediatric Participants With Attention-deficit Hyperactivity Disorder (ADHD)

Start: Oct 2019Est. completion: Dec 201913 patients
Phase 2Completed

PART B: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and Without mGluR Mutations

Start: Aug 2018Est. completion: Nov 2018109 patients
Phase 2Completed

PART A: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and With mGluR Mutations

Start: Aug 2017Est. completion: Oct 201869 patients
Phase 2Completed
NCT02327013Lundbeckvortioxetine 10 mg tablet

Investigating the Effect of Vortioxetine in Adult ADHD Patients

Start: Dec 2014Est. completion: Sep 2016227 patients
Phase 2Completed
NCT01711021Noven Pharmaceuticalsd-Amphetamine Transdermal Patch

Study to Evaluate Safety & Efficacy of d-Amphetamine Transdermal System vs Placebo in Children & Adolescents With ADHD

Start: Oct 2012Est. completion: Mar 2013110 patients
Phase 2Completed

Probiotics and the Microbiome: Clinical Intervention Trial for Anxiety and Depression

Start: Aug 2012Est. completion: Apr 201475 patients
Phase 2Unknown

Study of the Safety and Efficacy of OPC-34712 as a Complementary Therapy in the Treatment of Adult Attention Deficit/Hyperactivity Disorder

Start: Mar 2010Est. completion: Jun 2011740 patients
Phase 2Completed

Dose Finding Study in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)(174007/P05805/MK-8777-003)

Start: Apr 2008Est. completion: Mar 200967 patients
Phase 2Completed

Double-Blind, Four Week Trial Of [S,S]-Reboxetine And Atomoxetine In Adults With Attention Deficit Hyperactivity Disorder.

Start: Nov 20070
Phase 2Withdrawn

A Safety and Tolerability Study of ABT-089 in Adults With Attention Deficit-Hyperactivity Disorder (ADHD)

Start: Feb 2007Est. completion: Oct 2008141 patients
Phase 2Completed
NCT00409708SandozExtended Release Methylphenidate

Effects of Methylphenidate on Cellular Abnormalities in Children With Attention Deficit Hyperactivity Disorder (ADHD)

Start: Nov 2006142 patients
Phase 2Completed
NCT00279409Otsukaaripiprazole

Treatment of Children With ADHD Who do Not Fully Respond to Stimulants

Start: Jul 2006Est. completion: Feb 200910 patients
Phase 2Terminated

Dose-Finding Study to Evaluate the Efficacy and Safety of Modafinil as Treatment for Adults With ADHD

Start: May 2006Est. completion: Jan 2007370 patients
Phase 2Completed

CX717 in the Treatment of Adult ADHD

Start: Jul 2005Est. completion: Jan 200668 patients
Phase 2Completed
NCT00772161SandozMethylphenidate

Pharmacokinetics of Two Extended-Release Formulations of Methylphenidate in Children With Attention Deficit Hyperactivity Disorder (ADHD)

Start: Oct 2008Est. completion: Dec 200824 patients
Phase 1/2Completed
NCT04398225OtsukaCentanafadine

A Trial to Assess the Pharmacokinetics, Safety, and Tolerability of Centanafadine in Pediatric Subjects With Attention-deficit/Hyperactivity Disorder

Start: Jun 2020Est. completion: Apr 202132 patients
Phase 1Completed

Pharmacokinetic and Tolerability Study of NFC-1 in Subjects Aged 6-17 Years With ADHD

Start: Jan 2017Est. completion: Mar 201732 patients
Phase 1Completed

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

31 late-stage (Phase 3) programs, potential near-term approvals
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.