Almatica Pharma

NJ - Morristown

Pharmaceutical

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Focus: Small Molecules

Almatica Pharma is a life sciences company focused on Small Molecules.

NeurologyInfectious DiseasesCardiovascularPsychiatry

Funding Stage

PUBLIC

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Products & Portfolio (11)

CITALOPRAM HYDROBROMIDE

citalopram

Peak

ORAL · CAPSULE

unclear, but is presumed to be related to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT).

Major Depressive Disorder (MDD) in adults

CAPSULE, DELAYED RELEASE

antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS.

the following conditions: Major depressive disorder (MDD) in adults ( ) Generalized anxiety disorder (GAD) in adultsolder ( ) Diabetic peripheral neuropathic pain (DPNP) in adults ( ) Fibromyalgia (FM) in adultsolder ( ) Chronic musculoskeletal pain in adults ( )+1 more

escitalopram, the S-enantiomer of racemic citalopram, is presumed to be linked to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT).

analgesia, gabapentin prevents allodynia (pain-related behavior in response to a normally innocuous stimulus) and hyperalgesia (exaggerated response to painful stimuli). Gabapentin prevents pain-related responses in several models of neuropathic pain in rats and mice (e.g., spinal nerve ligation models, spinal cord injury model, acute herpes zoster infection model). Gabapentin also decreases pain-related responses after peripheral inflammation (carrageenan footpad test, late phase of formulin test), but does not alter immediate pain-related behaviors (rat tail flick test, formalin footpad acute phase). The relevance of these models to human pain is not known. Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid), but it does not modify GABA A or GABA B radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation. In radioligand binding assays at concentrations up to 100 μM, gabapentin did not exhibit affinity for a number of other receptor sites, including benzodiazepine, glutamate, N-methyl-D-aspartate (NMDA), quisqualate, kainate, strychnine-insensitive or strychnine-sensitive glycine; alpha 1, alpha 2, or beta adrenergic; adenosine A1 or A2; cholinergic, muscarinic, or nicotinic; dopamine D1 or D2; histamine H1; serotonin S1 or S2; opiate mu, delta, or kappa; cannabinoid 1; voltage-sensitive calcium channel sites labeled with nitrendipine or diltiazem; or at voltage-sensitive sodium channel sites labeled with batrachotoxinin A20-alpha-benzoate. Gabapentin did not alter the cellular uptake of dopamine, noradrenaline, or serotonin. In vitro studies with radiolabeled gabapentin have revealed a gabapentin binding site in areas of rat brain including neocortex and hippocampus. A high-affinity binding protein in animal brain tissue has been identified as an auxiliary subunit of voltage-activated calcium channels. However, functional correlates of gabapentin binding, if any, remain to be elucidated. It is hypothesized that gabapentin antagonizes thrombospondin binding to α2δ-1 as a receptor involved in excitatory synapse formation and suggested that gabapentin may function therapeutically by blocking new synapse formation.

Postherpetic Neuralgia (PHN)

ORAL · CAPSULE, EXTENDED RELEASE

gamma-aminobutyric acid-A (GABA A ) receptors in the brain and enhances GABA-mediated synaptic inhibition.

anxiety disorders in adultsevenly dividedthree times daily dosing with lorazepam tablets ()+1 more

2021

MACROBID

nitrofurantoin monohydrate/macrocrystalline

LOE Approaching

ORAL · CAPSULE

Mechanism of Action The mechanism of the antimicrobial action of nitrofurantoin is unusual among antibacterials. Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates which inactivate or alter bacterial ribosomal proteins and other macromolecules. As a result of such inactivations, the vital biochemical processes of protein synthesis, aerobic energy metabolism, DNA synthesis, RNA synthesis, and cell wall synthesis are inhibited. Nitrofurantoin is bactericidal in urine at therapeutic doses. The broad-based nature of this mode of action may explain the lack of acquired bacterial resistance to nitrofurantoin, as the necessary multiple and simultaneous mutations of the target macromolecules would likely be lethal to the bacteria.

pyelonephritisperinephric abscesses

1991

MACRODANTIN

nitrofurantoin macrocrystals

LOE Approaching

ORAL · CAPSULE

Mechanism of Action The mechanism of the antimicrobial action of nitrofurantoin is unusual among antibacterials. Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates which inactivate or alter bacterial ribosomal proteins and other acromolecules. As a result of such inactivations, the vital biochemical processes of protein synthesis, aerobic energy metabolism, DNA synthesis, RNA synthesis, and cell wall synthesis are inhibited. Nitrofurantoin is bactericidal in urine at therapeutic doses. The broad-based nature of this mode of action may explain the lack of acquired bacterial resistance to nitrofurantoin, as the necessary multiple and simultaneous mutations of the target macromolecules would likely be lethal to the bacteria.

urinary tract infectionsenterococciStaphylococcus aureus+4 more

1970

SERTRALINE HYDROCHLORIDE

sertraline hydrochloride

ORAL · TABLET, EXTENDED RELEASE

2022

ZESTORETIC

lisinopril and hydrochlorothiazide

Open Jobs (11)

Interview Prep Quick Facts

Founded: 2024

Portfolio: 11 approved products

Top TAs: Neurology, Infectious Diseases, Cardiovascular

Open Roles: 11 active jobs

Portfolio Health

Launch2 (18%)

Growth1 (9%)

Peak3 (27%)

LOE Approaching5 (45%)

11 total products

Therapeutic Area Focus

3 marketed

2 marketed

1 marketed

1 marketed

Marketed

Pipeline

Hiring Trend

Actively Hiring

Open Roles

+11

Added

-0

Filled/Removed

Based on last 4 crawl cycles

Almatica Pharma

Products & Portfolio (11)

Open Jobs (11)

Water - Wastewater FM Technician

Government Pricing Intern

Supply Chain Intern

Control Center Technician I

Chemist I

Facilities Maintenance Controls E&I Technician

Combination Product Manager, R&D

Associate Director, Legal Affairs

Packaging Technician

Manufacturing Technician

Associate Director Clinical Research & Develo

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