NDAORALCAPSULE
Approved
Dec 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
5/8 — Partial
MACROBID (nitrofurantoin monohydrate/macrocrystalline) by Almatica Pharma is mechanism of action the mechanism of the antimicrobial action of nitrofurantoin is unusual among antibacterials. Approved for pyelonephritis, perinephric abscesses. First approved in 1991.
Drug data last refreshed 19h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MACROBID is an oral nitrofuran antibacterial indicated for pyelonephritis and perinephric abscesses. It works by being reduced by bacterial flavoproteins into reactive intermediates that inhibit protein synthesis, energy metabolism, DNA/RNA synthesis, and cell wall synthesis. The broad-based mechanism of action results in bactericidal activity in urine with minimal acquired resistance.
$0.064BPart D
LOE ApproachingProduct is approaching loss of exclusivity with modest Medicare spending ($64K, 483 claims in 2023), indicating a niche mature brand facing revenue contraction and potential team restructuring.
Mechanism of Action
Mechanism of Action The mechanism of the antimicrobial action of nitrofurantoin is unusual among antibacterials. Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates which inactivate or alter bacterial ribosomal proteins and other macromolecules. As a result of such…
Pharmacologic Class:
Nitrofuran Antibacterial
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.